antiviral resistance

Objective. To determine frequency and spectrum of cytomegalovirus (CMV) resistance mutations to antiviral drugs in immunocompromised children. To study clinical course of resistant CMV infection in this patient population. Materials and Methods. This prospective study included 120 patients of the Dmitry Rogachev NMRC PHOI who mainly were recipients of allogeneic hematopoietic stem cell transplantation (HSCT) with confirmed CMV infection (median age – 8.9 years). The study inclusion criterion was the possible development of CMV drug resistance.

Objective. To identify mutations in UL97 gene associated with antiviral drug resistance in recipients of allogeneic hematopoietic stem cells transplants (allo-HSCT). Materials and Methods. A total of 9 HCMV DNA samples were studied. These samples were received from the blood of 8 allo-HSCT recipients who were infected with HCMV and undergoing treatment at NMRC of Hematology (Russia) over the period of 2016 to 2017. Sanger sequencing was used to find mutations.