antibiotic resistance

AMRmap – antibiotic resistance surveillance system in Russia

Objective. To review the basic principles and functionality of the AMRmap online resource. Materials and Methods. The AMRmap platform was developed using the R programming language and various downloadable modules – packages. The current annually updated version of EUCAST clinical breakpoints was applied for determination of categories of susceptibility to antimicrobial agents. Descriptive analysis includes calculation of absolute and relative frequencies, median values, and confidence intervals using the Wilson method.

AMRcloud: a new paradigm in monitoring of antibiotic resistance

Antimicrobial resistance is a growing threat to global public health and requires closer attention from the medical community. Antibiotic resistance monitoring systems play a key role in observing the antimicrobial susceptibility changes for rational …

Genotypes and metallo-beta-lactamases carriage in carbapenem-resistant Pseudomonas aeruginosa isolated from children in Moscow

Objective. To characterize the population structure and determine the genetic mechanisms of carbapenem resistance in nosocomial isolates of P. aeruginosa collected in Moscow in 2012-2016. Materials and methods. Carbapenem-resistant isolates were collected in two pediatric hospitals in Moscow. Antibiotics susceptibility of P. aeruginosa isolates was assessed using the E-tests and disk-diffusion method. Multilocus sequence typing (MLST) was used for genotyping of the isolates. The presence of metallo-betalactamase (MBL) genes was determined using real-time PCR.

The role of antimicrobial therapy stewardship in intensive care service

An analysis of current trends in the prevalence of nosocomial infections, their etiology and antibiotic resistance in pathogens was performed. Social and economic consequences of antimicrobial resistance as well as a medical community’s response were …

The molecular characteristics of antibiotic-resistant strains of Klebsiella pneumoniae isolated in traumatology hospitals

This study analyzed a prevalence of carbapenem-resistant Klebsiella pneumoniae strains obtained in the Privolzhsky Federal Medical Research Center units and their antibiotic resistance mechanisms. During the study year, the incidence of K. pneumoniae …

AMRmap: an online platform for monitoring antibiotic resistance

This review describes the new Internet resource AMRmap (map.antibiotic.ru), which provides data on antibiotic resistance in the Russian Federation.

Bacteriophage Preparations and Antibiotic Combinations: In vitro Activity Against Extensively Drug-Resistant Isolates of Pseudomonas aeruginosa ST235

The activity of 11 antibiotics combinations and 4 commercially available preparations for phagotherapy in regard to metallo-beta-lactamase (MBL) producing Pseudomonas aeruginosa clinical isolates of sequence type 235 (ST 235) belonging to the clonal …

Ceftibuten in the Treatment of Community-Acquired Urinary Tract Infections in Russia

Objective. Objectives. To investigate etiology and in vitro susceptibility of the most common pathogens causing community-acquired urinary tract infections (UTIs) in Russia. Materials and Methods. A total of 182 uropathogens isolated from urine samples of patients with communityacquired UTI were collected in Russia during 2013–2014 and included in the study. Results. Among the identified microorganisms the most prevalent uropathogens were Enterobacteriaceae (87,9%) and E. coli (68,1%). Drugs active against more than 90% of all Enterobacteriaceae isolates were fosfomycin (98,1%) and ceftibuten (93,1%).

Safety Issues With the Use of Antimicrobials in Current Clinical Practice

Due to increased use of antibiotics in current clinical practice it is very important to evaluate all risks of antimicrobial therapy. Pharmacovigilance plays a vital role in ensuring that doctors, together with the patient, have enough information …

Local Antimicrobial Resistance Profile as a Basis for the Choice of Antimicrobial Therapy of Staphylococcal Prosthetic Joint Infections

Objective. To determine the most effective antibiotics for therapy of infectious complications of prosthetic joint implantation caused by S. aureus and S. epidermidis. Materials and Methods. The antibiotic resistance profiles were determined for 535 clinical S. aureus and 211 S. epidermidis isolates. All the strains were isolated from the removed prosthesis and biological samples from patients with prosthetic joint infection (PJI). Susceptibility of clinical isolates was determined to 14 antibiotics according to EUCAST guidelines.