antibiotic consumption

Impact of the 10-valent pneumococcal conjugate vaccine on the incidence of respiratory and ENT diseases and antibiotic consumption in children under 5 years of age in Barnaul

Objective. To evaluate epidemiological efficacy of the 10-valent pneumococcal conjugated vaccine (PCV10) as assessed by the number of episodes of respiratory tract and ENT diseases and by the number of antibiotic courses prescribed for those diseases in children under 5 years of age in Barnaul. Materials and Methods. At the end of 2016, a total of 312 children under 60 months of age were enrolled into a retrospective cohort epidemiological study and divided into 2 cohorts (156 children each).

Simulation of bacterial resistance for different antibiotic consumption strategies based on the Escherichia coli resistance to cephalosporins

Objective. Objectives. To research the qualitative relationships between the level of antimicrobial resistance and the level of consumption of different antimicrobial agents, and to further apply this knowledge to minimize the level of resistance. Materials and Methods. An extensive simulation was performed based on the previously implemented model describing the relationship between a resistance and levels of antibiotic consumption. It makes possible to estimate the resistance growth rates in different antibiotic consumption strategies.

Prognostic Model of Microbial Resistance Based on the Relationship between Antibiotic Resistance and Consumption

Acquired bacterial resistance is one of the leading causes of morbidity and mortality attributed to infectious diseases. Simulations may provide opportunity to predict further spread of resistance and, to some extent, manage it. The objective of this …

Use of the Anti-Pseudomonas Vaccine for Prophylaxis and Treatment of Nosocomial Infections in Patients with Severe Burn Trauma

Objective. To explore potential of anti-Pseudomonas vaccine for the prophylaxis and treatment of infections caused by Pseudomonas aeruginosa in patients with severe burn trauma. Materials and Methods. This was a pilot, singlecenter randomized, parallel group study which enrolled patients with burns involving 10 to 60% of the body surface area. A total of 24 patients have received a course of «Pseudovac» vaccine (vaccination group), and 24 patients were included in the control arm (non-vaccination group).