aminoglycosides

The problem of genotypic variety of Acinetobacter baumannii isolated from patients with healthcare associated infections (HCAIs) are discussed. Carbapenemresistant strains, which are predominant in the study region, were shown to belong to the …

Objective. Aim. To evaluate current susceptibility patterns of the potential ocular bacterial pathogens to netilmicin in comparison with other antimicrobials in Russia. Materials and Methods. Overall in the study were included 200 S. aureus strains (100 — MRSA), 50 — coagulase-negative staphylococci, 50 — P. aeruginosa, 50 — Acinetobacter spp., and 50 — Enterobacteriaceae strains, isolated from outpatients and inpatients located in 17 cities of different regions of Russia during 2010–2014.

Objective. To determine bacterial pathogens causing ocular infections and their antimicrobial susceptibility patterns. Materials and Methods. This prospective microbiological study included a total of 235 isolates of aerobic microorganisms obtained from 235 patients in 10 Russian regions. Susceptibility to the following antimicrobials (ampicillin, amoxicillin, amoxicillin/clavulanate, oxacillin, penicillin, ciprofloxacin, levofloxacin, moxifloxacin, ofloxacin, norfloxacin, tobramycin, gentamicin, chloramphenicol, polymyxin B, tetracycline, and erythromycin) was determined using serial dilution method. Results. The most predominant pathogens in ocular infections were S.

Objective. To determine causative agents of hospitalacquired pneumonia (HAP), their incidence rates, and susceptibility to antimicrobial agents in patients with hematological malignancies in an intensive care unit (ICU). Materials and Methods. Broncho-alveolar lavage (BAL) specimens obtained from oncohaematologic patients with pneumonia hospitalized to the ICU between December 2009 and December 2010 were retrospectively studied. Results. A total of 142 BAL specimens were obtained from 72 hospitalized patients aged of 19 to 86 years.

Aminoglycosides is one of the main antimicrobial drug classes and continue to play a role in the treatment of several infections, although their relatively high rate of specific adverse reactions. Tobramycin is a typical antibiotic of this class …

In spite of development of number of new antimicrobials of other classes, aminoglycosides are still widely used in clinical practice. Their rapid bactericidal activity against the majority of common human pathogens as well as synergism with some …

The recent approaches to the treatment of endocarditis caused by Enterococcus spp., including strains that are resistant to conventional therapy, are discussed in the article. The possible ways of reduction of nephrotoxicity in elder patients and in …

The combination of ceftazidime with an aminoglycoside is a commonly used standard for empiric therapy of febrile neutropenia. A lot of attention is paid to the development of effective monotherapy for the treatment of this condition. One of the most …

The mechanisms of resistance to aminoglycoside antibiotics in Gram-negative nosocomial pathogens isolated in four Russian hospitals were studied. The most common and almost exclusive mechanism of aminoglycoside resistance was production of …