β-lactams

Objective. To assess biapenem PK parameters in critically ill adult patients and define the optimal dosing regimens based on TDM data. Materials and Methods. An open, prospective, uncontrolled, single-center study based on City Clinical Hospital No. 24, Moscow (October 2022 – April 2023), included patients over 18 years of age with a diagnosed severe bacterial infection received 600 mg of biapenem as 3-hour intravenous infusion every 12 hours in the intensive care unit.

In vitro studies and animal models have shown that clinical efficacy of β-lactams depends on the duration of time plasma drug concentration needed to exceed the minimal inhibitory concentration for causative microorganism (time above MIC). In …