β-lactamases

β-Lactam/β-Lactamase Inhibitor Combinations: Role in the Antimicrobial Therapy

Clinical Microbiology and Antimicrobial Chemotherapy. 2005; 7(4):393-402
At present, β-lactams are the most commonly used antimicrobials, but their clinical efficacy may be reduced because of the spread of antimicrobial resistance. The most important mechanism of resistance to β-lactams is an inhibition by the microbial …

β-Lactamases of Aerobic Gram-Negative Bacteria: Description, Principles of Classification, Methods of Detection and Typing

Clinical Microbiology and Antimicrobial Chemotherapy. 2001; 3(3):223-242
β-Lactamases are represented by extensive range of genetically and functionally different enzymes that are able to destroy β-lactams that leads to development of resistance to these antibiotics in β-lactamases producing bacteria. Intrinsic production …

Detection of Extended Spectrum β-lactamases by Phenotypic Methods in Gram-negative Bacteria

Clinical Microbiology and Antimicrobial Chemotherapy. 2001; 3(2):183-189
Production of extended-spectrum β-lactamases (ESBL) is the one of most widespread and clinically significant mechanism of resistance to modern β-lactams in members of the family Enterobacteriaceae. But the effectiveness of routine methods of …