Abstract
The paper provides an overview of the current guidelines on antimicrobial prophylaxis in trauma and orthopedic patients. During last dacades orthopedic involves the use of various implants for prolonged time. It changed the etiology of postoperative infectious complications and resulted in a revision of the guidelines for antimicrobial prophylaxis. The increase in the number of late infectious complications, changing the microbial etiology of surgical site infections, the need to remove or replace metal structures, considerable surgical aggression in repeated interventions associated with it, have made significant changes in the strategy of antibiotic prophylaxis in traumatology and orthopedics.
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