Abstract
In 2010 the world celebrates the 65th anniversary when the Nobel Prize in Physiology or Medicine was awarded to A. Fleming, H. Florey, and E.B. Chain «for the discovery of penicillin and its curative effect in various infectious diseases». Since then penicillin has saved infinitely many lives. The discovery of penicillin has become a strong impulse for the development of antimicrobial chemotherapy. Moreover, penicillin was the first drug that recognized a phenomenon such as resistance of microorganisms to antibiotics. However, penicillin is still an effective therapeutic agent in the treatment of several infections, such as tonsillopharyngitis, erysipelas, and syphilis.
-
1.
Сазыкин Ю.О. П. Эрлих и начало современной антимикробной химиотерапии. Антибиотики и химиотерапия 1999; 44(12):5-14.
-
2.
Литвинов А. В., Литвинова И. А. Нобелевская плеяда медицинский открытий 2008; 50-52.
-
3.
Ноздрачев А.Д., Марьянович А.Т., Поляков Е.А., Сибаров Д.А., Хавинсон В.Х. Нобелевские премии по физиологии или медицине за 100 лет, 2002; 270-4.
-
4.
Fleming A. On a remarkable bacteriolytic element found in tissues and secretions. Proc Roy Soc Ser B 1922;93:306- 17.
-
5.
Diggins F. The true history of the discovery of penicillin, with refutation of the misinformation in the literature. Br J Biomed Sci 1999; 56(2):83-93.
-
6.
Ligon B. Penicillin: its discovery and early development. Semin Pediatr Dis 2004; 15(1):52-7.
-
7.
Rolison G.N. From Pasteur to penicillin. The history of antibacterial chemotherapy Zbl Bact Hyg A 1988; 267, 207-315.
-
8.
Fleming A. Penicillin, Its Practical Application, Butterworth & Co Ltd London 1946; p 380.
-
9.
Waksman S.A. Streptomycin, Nature and Practical Application 1949; p 412.
-
10.
Saxon W. Anne Miller,90, first patient who was saved by penicillin. The New York Times June 9, 1999.
-
11.
Parascandola J. The history of antibiotics, a symposium, American Institute of the History of Pharmacy, Hadison, Wis, 1980; 137 pp.