Clinical Microbiology and Antimicrobial Chemotherapy. 2002; 4(1):49-60
The objective of this study was to estimate the potential economic and clinical effects of treatment of chronic hepatitis B with lamivudine and a-interferon in the Russian military healthcare system based on computer-generated decision analysis model. The main outcome of this analysis was to provide the rationale for more effective use of limited healthcare resources. The analysis showed that the use of lamivudine for treatment of chronic hepatitis B was more advantageous that a-interferon in increase of the life expectancy and reduction of life-time risk of development of both compensated and non-compensated cirrhosis and hepatocellular carcinoma.