Antimicrobials

Translated and reprinted with permission from “Journal of Chemotherapy” 2003; 15:357-68

The pharmaceutical qualities of 34 ceftriaxone generic products were compared with Rocephin as the reference standard.Quality standards specified in the European …

In vitro studies and animal models have shown that clinical efficacy of β-lactams depends on the duration of time plasma drug concentration needed to exceed the minimal inhibitory concentration for causative microorganism (time above MIC). In …

To understand the relationship between drug dose and efficacy, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics need to be integrated. There are two patterns of antimicrobial activity: time-dependent killing and concentration-dependent …

Antiretroviral drugs today are the basis of HIV therapy. The severe and progressive nature of the disease and the need for lifelong therapy make the correct choice of drugs for HIV therapy of particular importance. Alarge number of antiretroviral …

The aim of this study was to review published data on efficacy and safety of prophylaxis and empirical therapy with antifungals in neonates. We have found 37 reports on use of antimycotics in neonates, which had been published by June 2003. Of 37 …

Invasive mycoses becoming more and more important problem of the modern medicine that is reflecting the increasing number of immunocompromised patients population. Despite the fact that the main causative agents remain Candida albicans, Aspergillus …

Reprinted from «International Journal of Antimicrobial Agents» 2002; 20:313,9 – with permission from Elsevier. (The translation has not been rewieved by Elsevier prior to printing).

A number of studies have been carried out on the effect of several …

The present in vitro study of antimicrobial susceptibility of nosocomial Gram,negative pathogens to cefepime and other antimicrobials has been performed by the ROSNET study group in 28 medical institutions in Russia. The most active agent against …

This paper presents analysis of microbiological, clinical and pharmacoeconomic studies of carbapenems. Use of carbapenems during the last two decades was not associated with emergence of resistance to these agents among clinically significant human …