Антибактериальные препараты, снижающие риск развития резистентности

Клиническая микробиология и антимикробная химиотерапия. 2021; 23(2):184-194

​ Зигангирова Н.А., Лубенец Н.Л., Зайцев А.В., Пушкарь Д.Ю.
10.36488/cmac.2021.2.184-194
факторы вирулентности хронические инфекции терапия профилактика антивирулентные препараты
Раздел
Антимикробные препараты
Тип
Обзор
Публикация
Клиническая микробиология и антимикробная химиотерапия. 2021; 23(2):184-194

Аннотация

Ближайшие десятилетия важнейшей задачей медицинской микробиологии в области терапии инфекционных заболеваний станет создание антибактериальных препаратов, эффективных в отношении антибиотикорезистентных патогенов и снижающих риск развития резистентности. В связи с этим наряду с поиском новых антибиотиков, необходимо разрабатывать альтернативные стратегии, направленные на снижение селективного давления препаратов на патогены в результате подавления вирулентности без влияния на жизнеспособность. В качестве мишеней для подавления выбираются факторы вирулентности, определяющие ключевые этапы как острого, так и хронического инфекционного процесса: адгезины, токсины, система коммуникации бактерий, секреторные системы. Антивирулентные препараты могут быть эффективны при лечении нозокомиальных, осложненных и хронических инфекций в составе комплексной терапии и для профилактики. В обзоре приведены результаты исследований препаратов, которые либо показали эффективность на модельных инфекциях у животных, либо перешли на стадию клинических исследований, либо уже зарегистрированы. Разработка эффективных схем комбинированной терапии позволит минимизировать риски приобретения резистентности.

Наиля Ахатовна Зигангирова

ФГБУ «Национальный исследовательский центр эпидемиологии и микробиологии им. почетного академика Н.Ф. Гамалеи» Минздрава России, Москва, Россия

Лубенец Н.Л.

ФГБУ «Национальный исследовательский центр эпидемиологии и микробиологии им. почетного академика Н.Ф. Гамалеи» Минздрава России, Москва, Россия

Зайцев А.В.

ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия

Пушкарь Д.Ю.

ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России, Москва, Россия

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