Новые схемы и новые препараты в лечении туберкулеза: шагаем в ногу?

Клиническая микробиология и антимикробная химиотерапия. 2021; 23(1):27-42

​ Рузанов Д.Ю., Скрягина Е.М., Буйневич И.В., Гопоняко С.В., Баласанянц Г.С., Химова Е.С.
10.36488/cmac.2021.1.27-42
туберкулез лекарственная устойчивость схемы лечения бедаквилин деламанид
Раздел
Болезни и возбудители
Тип
Обзор
Публикация
Клиническая микробиология и антимикробная химиотерапия. 2021; 23(1):27-42

Аннотация

Появление и повсеместное внедрение в практику ускоренных методов детекции и тестирования лекарственной устойчивости микобактерий туберкулеза привели к резкому уменьшению сроков постановки диагноза рифампициноустойчивого туберкулеза и возможности раннего назначения этиотропного лечения. Но постоянно растущая устойчивость микобактерий к противотуберкулезным препаратам снижает эффективность лечения. Кроме того, применяемые схемы лечения лекарственно-устойчивого туберкулеза из-за низкой стерилизующей активности требуют длительного использования, что ведет к повышению токсичности препаратов, снижению приверженности лечению пациентов, значительному увеличению ресурсов здравоохранения. Современная фтизиатрия нуждается в разработке новых эффективных лекарственных средств и коротких схем лечения, без чего невозможна элиминация туберкулеза к 2050 г. В данном обзоре авторы обобщили информацию о лечении лекарственно-устойчивого туберкулеза, в том числе сведения о перепрофилированных лекарствах, новых препаратах и схемах лечения.

Рузанов Дмитрий Юрьевич

Республиканский научно-практический центр медицинских технологий, информатизации, управления и экономики здравоохранения, Минск, Республика Беларусь

Скрягина Е.М.

Республиканский научно-практический центр пульмонологии и фтизиатрии, Минск, Республика Беларусь

Буйневич И.В.

УО «Гомельский государственный медицинский университет», Гомель, Республика Беларусь

Гопоняко С.В.

УО «Гомельский государственный медицинский университет», Гомель, Республика Беларусь

Баласанянц Г.С.

ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Минобороны России, Санкт-Петербург, Россия

Химова Е.С.

ФГБОУ ВО «Северный государственный медицинский университет» Минздрава России, Архангельск, Россия

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