Резистентность Candida glabrata к эхинокандинам: некоторые аспекты проблемы

Клиническая микробиология и антимикробная химиотерапия. 2019; 21(4):324-329

​ Веселов А.В.
10.36488/cmac.2019.4.324-329
кандиды C. glabrata эхинокандины резистентность
Раздел
Антибиотикорезистентность
Тип
Обзор
Публикация
Клиническая микробиология и антимикробная химиотерапия. 2019; 21(4):324-329

Аннотация

Инвазивный кандидоз является распространенным, тяжело протекающим и часто трудно поддающимся лечению осложнением у различных категорий пациентов. Несмотря на то что Candida albicans в большинстве случаев сохраняет лидирующие позиции в качестве этиологической причины, такой возбудитель как Candida glabrata становится все более актуальным патогеном, особенно у пациентов с гемобластозами, получавшими до этого терапию азоловыми антимикотиками. Согласно текущим версиям практических рекомендаций, для терапии системных инфекций, вызванных C. glabrata, препаратами выбора являются эхинокандины. Обладая высокой фунгицидной активностью, в отличие от азолов, они позволяют в большинстве случаев достичь клинической эффективности терапии при выделении данного возбудителя. Однако появляются данные, указывающие на селекцию штаммов C. glabrata со сниженной чувствительностью или устойчивостью к эхинокандинам. В данной статье кратко представлены актуальные данные о проблеме устойчивости C. glabrata к препаратам этого класса, а также приведены результаты российских исследований in vitro.

Веселов Александр Валерьевич

НИИ антимикробной химиотерапии ФГБОУ ВО СГМУ Минздрава России, Смоленск, Россия

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