Бактериальные инфекции у пациентов с циррозом печени

Клиническая Микробиология и Антимикробная Химиотерапия. 2017; 19(4):284-295

​ Литвинчук Д.В., Данилов Д.Е., Соловей Н.В., Карпов И.А.
бактериальные инфекции цирроз печени спонтанный бактериальный перитонит пневмония инфекция мочевых путей антибактериальная терапия
Раздел
Болезни и возбудители
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2017; 19(4):284-295

Аннотация

У пациентов с циррозом печени значительно повышен риск развития бактериальных инфекций. Бактериальные осложнения являются причиной более 30% госпитализаций пациентов с циррозом и вносят значительный вклад в летальность. Наиболее распространёнными формами бактериальных инфекций у пациентов с циррозом печени являются спонтанный бактериальный перитонит, пневмония, инфекции мочевых путей, инфекции кожи и мягких тканей. В данной статье описаны ключевые патофизиологические механизмы, лежащие в основе повышенной восприимчивости к бактериальным инфекциям при циррозе печени. Представлена этиологическая структура отдельных форм бактериальных инфекций у пациентов с циррозом. Рассмотрены особенности воспалительного ответа и антимикробного иммунного ответа у пациентов с циррозом, а также клинико-лабораторные особенности бактериальных инфекций. Приведены схемы эмпирической антибактериальной терапии, а также принципы проведения первичной и вторичной антибиотикопрофилактики спонтанного бактериального перитонита.

Литвинчук Дмитрий Вадимович

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь

Данилов Д.Е.

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь

Соловей Н.В.

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь

Карпов Игорь Александрович

УО «Белорусский государственный медицинский университет», Минск, Республика Беларусь

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