Обзор доказательных данных по применению даптомицина при грамположительных инфекциях

Клиническая Микробиология и Антимикробная Химиотерапия. 2016; 18(4):270-281

​ Попов Д.А., Зубарева Н.А., Дехнич А.В.
даптомицин липопептиды антибиотикорезистентность инфекции кожи и мягких тканей бактериемия эндокардит S. aureus Enterococcus spp
Раздел
Антимикробные препараты
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2016; 18(4):270-281

Аннотация

Даптомицин является единственным клинически применяемым представителем циклических липопептидов. Он обладает выраженной бактерицидной активностью, в том числе в отношении микробных клеток в составе биоплёнок. В спектр активности даптомицина входят практически все клинически значимые грам(+) бактерии, включая штаммы, устойчивые к другим классам антимикробных препаратов. На настоящий момент даптомицин зарегистрирован по двум показаниям: осложнённые инфекции кожи и мягких тканей и инфекции кровотока, вызванные S. aureus, включая бактериемию и эндокардит. Однако есть многочисленные исследования и наблюдения, показывающие потенциальную возможность использования даптомицина и при ряде других заболеваний, таких как инфекции костей и суставов, фебрильная нейтропения и др., вызванных полирезистентными грам(+) штаммами.

Попов Дмитрий Александрович

ФГБУ «НЦССХ им. А.Н. Бакулева» Минздрава России, Москва, Россия

Зубарева Н.А.

ФГБОУ ВО «ПГМУ им. Е.А. Вагнера» Минздрава России, Пермь, Россия

Дехнич Андрей Владимирович

НИИ антимикробной химиотерапии ФГБОУ ВО СГМУ Минздрава России, Смоленск, Россия

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