Даптомицин: обзор фармакологических, клинических и микробиологических параметров

Клиническая Микробиология и Антимикробная Химиотерапия. 2010; 12(4):295-313

​ Дехнич А.В., Данилов А.И.
даптомицин липопептиды антибиотикорезистентность инфекции кожи и мягких тканей бактериемия эндокардит S. aureus Enterococcus spp
Раздел
Антимикробные препараты
Тип
Журнальная статья
Публикация
Клиническая Микробиология и Антимикробная Химиотерапия. 2010; 12(4):295-313

Аннотация

Даптомицин является первым и единственным дошедшим до клинического применения представителем класса циклических полипептидов, активных в отношении грам(+) микроорганизмов. В отличие от большинства других антибиотиков, он обладает быстрой бактерицидной активностью, в том числе в отношении медленно делящихся микробных клеток и микробных клеток в составе биопленок. В спектр активности даптомицина входят практически все клинически значимые грам(+) бактерии, включая штаммы, устойчивые к другим классам антимикробных препаратов. На настоящий момент даптомицин зарегистрирован по двум показаниям — осложненные инфекции кожи и мягких тканей в дозе 4 мг/кг 1 раз в сутки и инфекции кровотока, вызванные S. aureus, включая бактериемию и правосторонний эндокардит, в дозе 6 мг/кг 1 раз в сутки. Но есть многочисленные исследования и наблюдения, показывающие потенциальную возможность использования даптомицина и при ряде других заболеваний, таких как инфекции костей и суставов, фебрильная нейтропения и др., вызванных полирезистентными грам(+) штаммами. Учитывая клинико-фармакологический и микробиологический профиль препарата, а также ситуацию с антибиотикорезистентностью грам(+) возбудителей в России, даптомицин однозначно должен занять одно из важных мест в антибиотикотерапии в стационарах нашей страны.

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