Clinical Microbiology and Antimicrobial Chemotherapy. 2025; 27(3):309-316
Objective. To determine frequency and spectrum of cytomegalovirus (CMV) resistance mutations to antiviral drugs in immunocompromised children. To study clinical course of resistant CMV infection in this patient population.
Materials and Methods. This prospective study included 120 patients of the Dmitry Rogachev NMRC PHOI who mainly were recipients of allogeneic hematopoietic stem cell transplantation (HSCT) with confirmed CMV infection (median age – 8.9 years). The study inclusion criterion was the possible development of CMV drug resistance.