β-lactams | CMAC

β-lactams

Pharmacokinetics of biapenem in critically ill patients

Objective. To assess biapenem PK parameters in critically ill adult patients and define the optimal dosing regimens based on TDM data. Materials and Methods. An open, prospective, uncontrolled, single-center study based on City Clinical Hospital No. 24, Moscow (October 2022 – April 2023), included patients over 18 years of age with a diagnosed severe bacterial infection received 600 mg of biapenem as 3-hour intravenous infusion every 12 hours in the intensive care unit.

Continuous Infusion of β-Lactam Antibiotics as an Alternative to Conventional Methods of Administration

In vitro studies and animal models have shown that clinical efficacy of β-lactams depends on the duration of time plasma drug concentration needed to exceed the minimal inhibitory concentration for causative microorganism (time above MIC). In …