Regional system for automated validation of microbiological reports and antimicrobial resistance monitoring: the experience of the Yamalo-Nenets Autonomous Okrug | CMAC

Regional system for automated validation of microbiological reports and antimicrobial resistance monitoring: the experience of the Yamalo-Nenets Autonomous Okrug

Clinical Microbiology and Antimicrobial Chemotherapy. 2025; 27(4):494-505

​ Kutlovskaya E.N., Vinogradova A.G., Lyutova E.Yu., Belorus O.V., Bikbulatova L.N., Menshakov V.V., Zakharova M.G., Novikov S.V., Kuzmenkov A.Yu., Aekenova B.A., Amangel’dieva O.S., Val’ter E.P., Giljazova D.R., Goncharenko S.A., Zhuravkova A.Ju., Zinevich A.A., Kafarova S.F., Koksharova I.A., Magda Ju.A., Medvedeva N.A., Nechaev P.A., Nugumanov R.A., Nuhova M.A., Pesterev V.S., Petrova Ju.Ju., Poskrebalova S.V., Rekunova A.A., Rogozhina L.A., Rybina S.V., Salim’janova G. S., Sentemova N.L., Suslikov A.V., Chausova E.V., Chursin V.V., Shabanova A.O., Shherbakova N.V.
10.36488/cmac.2025.4.494-505
antimicrobial resistance monitoring automated validation microbiological report regional system
Section
Personal Experience
Type
Original Article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2025; 27(4):494-505

Objective.

Creation and evaluation of the effectiveness of an integrated system for automatic validation of microbiological reports and monitoring of antimicrobial resistance (AMR) on real time at the regional level within the Yamalo-Nenets Autonomous Okrug (YNAO).

Materials and Methods.

The prospective study was conducted from October 2023 to June 2025, based on the Medical Information and Analytical Center and five largest hospitals in the YNAO. The study design included a comparative analysis of AMR monitoring status before and after the implementation of the digital platform. The objects of the study were data from 11728 microbiological reports, 12216 isolates, and the results of a survey conducted among 53 doctors. The period after implementation lasted 12 months, from June 2024 to June 2025. The primary endpoint was a comprehensive evaluation of the system based on criteria, including automatic validation level, coverage of healthcare facilities, data accessibility, and analytical capabilities. Methods for assessment included analyzing the operational data of the platform, conducting a structured survey among doctors, and assessing cost-effectiveness using an approved methodology.

Results.

After implementation, the system achieved 100% coverage of the planned healthcare facilities (5 hospitals). A total of 11728 cases were processed, of which 77,2% (9057⁄11728) generated expert reports by the system (median – 3 reports per analysis). In 19,3% of cases (2267⁄11728), high- and medium-risk reports were identified, indicating potential therapy errors. A survey of 53 doctors found that 66% (35⁄53) do not experience difficulties reading new opinion forms, and 87% (46⁄53) regularly read system-generated comments, with 96% (51⁄53) finding them useful for antibiotic selection. The economic impact of the system amounts to 110 million rubles per year, with potential annual prevention of up to 14 deaths.

Conclusions.

The introduction of the system for AMR monitoring and automated validation of microbiological reports in the Yamalo-Nenets Autonomous District has led to the standardization of microbiological diagnostics, increased safety of antimicrobial treatment, and the provision of upto-date epidemiological data in real-time. The system has shown significant clinical and economic benefits, demonstrating the feasibility of replicating it in other regions of the Russian Federation.

Kutlovskaya E.N.

Salekhard District Clinical Hospital, Salekhard, Russia

Alina G. Vinogradova

Smolensk State Medical University, Smolensk, Russia

Lyutova E.Yu.

Noyabrsk Central City Hospital, Noyabrsk, Russia

Belorus O.V.

Medical Information and Analytical Center of the Yamalo-Nenets Autonomous Okrug, Salekhard, Russia

Bikbulatova L.N.

Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Menshakov V.V.

Medical Information and Analytical Center of the Yamalo-Nenets Autonomous Okrug, Salekhard, Russia

Zakharova M.G.

Department of Health of the Yamalo-Nenets Autonomous Okrug, Salekhard, Russia

Novikov S.V.

Department of Health of the Yamalo-Nenets Autonomous Okrug, Salekhard, Russia

Kuzmenkov Alexey Yuryevich

Smolensk State Medical University, Smolensk, Russia

Aekenova B.A.

State Budgetary Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Noyabrsk Central District Hospital", Noyabrsk

Amangel'dieva O.S.

State Budgetary Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Nadym Central District Hospital", Novy Urengoy

Val'ter E.P.

State Budgetary Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Nadym Central District Hospital", Novy Urengoy

Giljazova D.R.

State Budgetary Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Nadym Central District Hospital", Novy Urengoy

Goncharenko S.A.

State Budgetary Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Tarko-Sale Central District Hospital", Tarko-Sale

Zhuravkova A.Ju.

State Budgetary Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Nadym Central District Hospital", Nadym

Zinevich A.A.

State Budgetary Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Salekhard District Clinical Hospital", Salekhard

Kafarova S.F.

State Budgetary Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Nadymskaya" Central District Hospital, Nadym

Koksharova I.A.

Yamalo-Nenets Autonomous Okrug State Healthcare Institution "Noyabrsk Central District Hospital", Noyabrsk

Magda Ju.A.

Yamalo-Nenets Autonomous Okrug State Healthcare Institution "Novourengoy Central District Hospital", Novy Urengoy

Medvedeva N.A.

Yamalo-Nenets Autonomous Okrug State Healthcare Institution "Nadym Central District Hospital", Nadym

Nechaev P.A.

Salekhard District Clinical Hospital, Salekhard

Nugumanov R.A.

Yamalo-Nenets Autonomous Okrug State Healthcare Institution "Tarko-Sale Central District Hospital", Tarko-Sale

Nuhova M.A.

Yamalo-Nenets Autonomous Okrug State Healthcare Institution "Nadym Central District Hospital", Nadym

Pesterev V.S.

Yamalo-Nenets Autonomous Okrug State Healthcare Institution "Novourengoy Central District Hospital", Novy Urengoy

Petrova Ju.Ju.

Yamalo-Nenets Autonomous Okrug State Healthcare Institution "Navourengoy Central District Hospital", Novy Urengoy

Poskrebalova S.V.

Yamalo-Nenets Autonomous Okrug State Healthcare Institution "Nadym Central District Hospital", Nadym

Rekunova A.A.

Yamalo-Nenets Autonomous Okrug State Healthcare Institution "Nadym Central District Hospital", Nadym

Rogozhina L.A.

State Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Noyabrsk Central District Hospital", Noyabrsk

Rybina S.V.

State Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Noyabrsk Central District Hospital", Noyabrsk

Salim'janova G. S.

State Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Nadym Central District Hospital", Nadym

Sentemova N.L.

State Healthcare Institution of the Yamalo-Nenets Autonomous Okrug "Nadym Central District Hospital", Nadym

Suslikov A.V.
Chausova E.V.
Chursin V.V.
Shabanova A.O.
Shherbakova N.V.
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