Population structure and genetic characteristics of Streptococcus pneumoniae isolates from children with chronic respiratory diseases | CMAC

Population structure and genetic characteristics of Streptococcus pneumoniae isolates from children with chronic respiratory diseases

Clinical Microbiology and Antimicrobial Chemotherapy. 2024; 26(4):480-486

​ Komyagina T.M., Tryapochkina A.S., Alyabieva N.M., Lazareva A.V., Gorinova Yu.V., Simonova O.I.
10.36488/cmac.2024.4.480-486
Streptococcus pneumoniae epidemiology serotypes antimicrobial resistance cystic fibrosis congenital malformations of the bronchi and lungs
Section
Personal Experience
Type
Original Article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2024; 26(4):480-486

Objective.

To study the population and genetic structure of S. pneumoniae isolated from children with cystic fibrosis (CF) and congenital malformations of the bronchi and lungs (CM) over the period 2011 to 2021, their serotype diversity in pre-vaccination and post-vaccination periods and susceptibility to antimicrobials.

Materials and Methods.

A total of 140 S. pneumoniae isolates (during 2011-2021) from respiratory samples of patients with CM or CF were included in the study. For all isolates serotypes, antimicrobial susceptibility, resistance genes to β-lactams and macrolides, and sequence types were determined.

Results.

We observed a general increase in non-vaccine serotypes mainly due to serotype 11A. Antimicrobial resistance was higher in vaccine serotypes compared to non-vaccine serotypes. There was an increase in the number of S. pneumoniae isolates with reduced susceptibility to penicillin among vaccine serotypes. All ermB/mef-containing islated belonged to the cMLSB phenotype and demonstrated high levels of macrolide resistance and multidrug resistance (MDR).

Conclusions.

Continuous monitoring of the population structure of S. pneumoniae in children with chronic bronchopulmonary diseases is necessary. The detection of MDR serotypes with new sequence types indicates the great importance of continuing surveillance of antimicrobial resistance of S. pneumoniae.

Tatiana M. Komyagina

National Medical Research Center for Children’s Health, Moscow, Russia

Tryapochkina A.S.

National Medical Research Center for Children’s Health, Moscow, Russia

Alyabieva N.M.

National Medical Research Center for Children’s Health, Moscow, Russia

Lazareva A.V.

National Medical Research Center for Children’s Health, Moscow, Russia

Gorinova Yu.V.

National Medical Research Center for Children’s Health, Moscow, Russia

Simonova O.I.

National Medical Research Center for Children’s Health, Moscow, Russia

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