Possibilities of using the AMRcf online registr y in patients with cystic fibrosis | CMAC

Possibilities of using the AMRcf online registr y in patients with cystic fibrosis

Clinical Microbiology and Antimicrobial Chemotherapy. 2024; 26(4):417-425

​ Maximova E.A., Kuzmenkov A.Yu., Lyamin A.V., Kozlov A.V., Kondratyeva E.I., Kondratenko O.V.
10.36488/cmac.2024.4.417-425
AMRcf AMRcloud online platform surveillance microbiota cystic fibrosis
Section
Diseases and Pathogens
Type
Original Article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2024; 26(4):417-425

Objective.

To evaluate the results of implementing the AMRcf and AMRcloud platforms for microbiological surveillance studies of patients with cystic fibrosis (CF) into the routine practice of a microbiological laboratory.

Materials and Methods.

The study was performed on the basis of the Department of Microbiology of the Clinical diagnostic laboratory of the Clinics of the Samara State Medical University. To perform the study, the following computer programs were introduced into routine practice: AMRcf (online microbiological registry for CF patients) and AMRcloud (online platform for analysis of collected data on antibiotic resistance). The results of microbiologic studies conducted from 2018 to 2023 from 16 regions of the Russian Federation were retrospectively entered into the AMRcf online platform.

Results.

A total of 3052 isolates isolated from CF patients were entered into the AMRcf registry database for individual analysis. The generated data pool in AMRcf was tested for automated upload to the AMRcloud platform, which was subsequently used to analyze the accumulated data at the level of the study population. Implementation of the AMRcf platform allowed to provide: storage and access to microbiological data of CF patients; integration of data from different regions and sources, individual microbiological anamnesis for each patient in real time, interaction of specialists from different fields dealing with the problem of microbiological diagnosis and antimicrobial therapy in CF patients.

Conclusions.

Implementation of the AMRcf online registry and the AMRcloud online platform in the workflow of the microbiology laboratory enables individualized surveillance of the microbiota of cystic fibrosis patients in different regions of the Russian Federation. Data from the AMRcf and AMRcloud online platforms can be used in routine practice by microbiologists, clinicians, and epidemiologists.

Elena A. Maximova

Samara State Medical University, Samara, Russia

Kuzmenkov Alexey Yuryevich

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Artem V. Lyamin

Samara State Medical University, Samara, Russia

Andrey V. Kozlov

Samara State Medical University, Samara, Russia

Kondratyeva E.I.

Research Centre for Medical Genetics named after academician N.P. Bochkov, Moscow, Russia

Olga V. Kondratenko

Samara State Medical University, Samara, Russia

  • 1. O’Neill J. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. The review on antimicrobial resistance. 2014. Available at: https://amr-review.org/Publications.html. Accessed September 2024.
  • 2. Strachunsky L.S., Andreeva I.V. Self-medication with antibiotics in Russia. Remedium. 2004;12:19-25. Russian.
  • 3. Tamma P.D., Avdic E., Keenan J.F., Zhao Y., Anand G., Cooper J., et al. What is the more effective antibiotic stewardship intervention: pre-prescription authorization or post-prescription review with feedback? Clin Infect Dis. 2017;64(5):537-543. DOI: 10.1093/cid/ciw780
  • 4. Kuzmenkov A.Yu., Vinogradova A.G., Trushin I.V., Kozlov R.S. Practice of local antibiotic resistance monitoring at hospitals in various regions of the Russian Federation. Kliniceskaa mikrobiologia i antimikrobnaa himioterapia. 2022;24(1):31-38. Russian. DOI: 10.36488/cmac.2022.1.31-38
  • 5. Morency-Potvin P., Schwartz D.N., Weinstein R.A. Antimicrobial stewardship: how the microbiology laboratory can right the ship. Clin Microbiol Rev. 2017;30(1):381407. DOI: 10.1128/CMR.00066-16
  • 6. Kuzmenkov A.Yu., Vinogradova A.G. Antimicrobial resistance monitoring: a review of information resources. Bulletin of Siberian Medicine. 2020;19(2):163-170. Russian. DOI: 10.20538/1682-0363-2020-2-163-170
  • 7. Baranov A.A., Namazova-Baranova L.S., Kutsev S.I., Avdeev S.N., Polevichenko E.V., Belevskiy A.S., et al. Modern approaches in management of children with cystic fibrosis. Pediatric pharmacology. 2022;19(2):153-195. Russian. DOI: 10.15690/pf.v19i2.2417
  • 8. Kondratenko O.V., Zhestkov A.V., Medvedeva E.D., Ermolaeva A.V., Vasileva E.A. Monitoring of the microflora of the paranasal sinuses as a method of early prevention of colonization of the lower respiratory tract of clinically significant strains of microorganisms in patients with сystic fibrosis. Izvestija Samarskogo nauchnogo centra Rossijskoj akademii nauk. 2018;20(5):569-578. Russian.
  • 9. Kondratenko OV., Zhestkov A.V., Ljamin A.V., Polikarpova S.V. Microbiota of the respiratory tract in patients with cystic fibrosis. Bjulleten’ Orenburgskogo nauchnogo centra UrO RAN. 2019;3:6. Russian. DOI: 10.24411/2304-9081-2019-13008
  • 10. Lyamin A.V., Zolotov M.O., Kondratenko O.V., Maksimova E.A., Ismatullin D.D., Bochkareva P.V. Prevalence of antimicrobial-resistant Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis. Meditsinskiy sovet. 2023;(20):114-120. Russian. DOI: 10.21518/ms2023-346
  • 11. Voronina O. L., Ryzhova N. N., Kunda M. S., Aksenova E.I., Sharapova N.E., Amelina E.L., et al. Major tendencies in burkholderia diversity changes, infecting russian patients with cystic fibrosis. Sibirskoe medicinskoe obozrenie. 2019;(2):116. Russian. DOI: 10.20333/2500136-2019-2-80-88
  • 12. Kondratenko O.V., Ljamin A.V., Zhestkov A.V. Structure and antibiotic resistance microflora isolated from lower respiratory tract in patients with cystic fibrosis in Samara. Prakticheskaja medicina. 2012;56(1):85-88. Russian.
  • 13. Polikarpova S.V., Zhilina S.V., Kondratenko O.V., Lyamin A.V., Borzova O.V., Zhestkov A.V. Guidelines for the microbiologic diagnosis of respiratory tract infections in patients with cystic fibrosis. Triada, 2019. 128 p. Russian.
  • 14. Likstanov M.I., Kuzmenko S.A., Mozes V.G., Movshina I.N., Barinova E.V., Kovalivnich O.V., et al. Prevention of infections associated with the provision of medical care in patients with cystic fibrosis in a multidisciplinary hospital in Kuzbass for the period 2020-2021. Medicine in Kuzbass. 2022;21(4):5-9. Russian. DOI: 10.24412/2687-0053-2022-4-5-9
  • 15. Kondratieva E.I., Kashirskaya N.Yu., Kapranov N.I. National consensus “Cystic fibrosis: definition, diagnostic criteria, therapy”. 2016. Russian.
  • 16. Petrova L.V., Kuzmenkov A.Yu., Kamyshova D.A., Vinogradova A.G., Gusarov V.G., Zamyatin M.N. Experience in implementing the AMRcloud online platform for local antimicrobial resistance surveillance in a tertiary care hospital. Kliniceskaa mikrobiologia i antimikrobnaa himioterapia. 2022;24(1):39-46. Russian. DOI: 10.36488/cmac.2022.1.39-46
  • 17. Kuzmenkov A.Yu., Vinogradova A.G., Trushin I.V., Avramenko A.A., Edelstein M.V., Dekhnich A.V., et al. AMRcloud: a new paradigm in monitoring of antibiotic resistance Kliniceskaa mikrobiologia i antimikrobnaa himioterapia. 2019;21(2):119-124. Russian. DOI: 10.36488/cmac.2019.2.119-124
  • 18. Recommendations “Susceptibility testing of microorganisms to antimicrobial agents. Version 2021-01.” Available at: www.antibiotic.ru/files/321/clrec-dsma2021.pdf. Aссessed September 2024. Russian.
Views
0 Abstract
0 PDF
0 Crossref citations
Shared