Abstract
Breast surgery is a broad field that includes both surgical treatment of breast diseases and various variants of reconstructive and plastic surgeries for breast correction. Despite the fact that according to the accepted classification breast interventions are considered to be «clean», the incidence of infectious complications in surgical treatment of breast cancer is higher than in conventional «clean» surgical interventions, and the rate increases significantly in case of one-stage breast reconstruction with expanders or implants. In these practical guidelines for the first time in Russia a detailed analysis of the available current publications on antibiotic prophylaxis and treatment of infectious complications (surgical site infections and implantassociated infections) is presented and specific schemes of antibiotic use in breast surgery for both breast cancer and reconstructive-plastic surgeries are proposed.
Institute of Antimicrobial Chemotherapy, Smolensk, Russia
P.A. Hertzen Moscow Oncology Research Institute, Moscow, Russia
Institute of Antimicrobial Chemotherapy, Smolensk, Russia
P.A. Hertzen Moscow Oncology Research Institute, Moscow, Russia
P.A. Hertzen Moscow Oncology Research Institute, Moscow, Russia
Institute of Antimicrobial Chemotherapy, Smolensk, Russia
Smolensk Regional Clinical Hospital, Smolensk, Russia
Smolensk State Medical University, Smolensk, Russia
P.A. Hertzen Moscow Oncology Research Institute, Moscow, Russia
Institute of Antimicrobial Chemotherapy, Smolensk, Russia
-
1.
Bray F., Laversanne M., Sung H., Ferlay J., Siegel R.L., Soerjomataram I., Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-263.
DOI: 10.3322/CAAC.21834
-
2.
Kaprin A.D., Starinsky V.V., Shakhzadova A.O. The state of oncological care for the population of Russia in 2022: P.A. Herzen Moscow State Medical Research Institute – branch of the Federal State Budgetary Institution "NMIC of Radiology". Ministry of Health of Russia. 2023;21-22. Russian.
-
3.
National Institute for Health and Care Excellence (NICE). Improving outcomes in breast cancer. Cancer service guideline [CSG1]. Accessed 2002. Available at:www.nice.org.uk/guidance/csg1. Accessed August 2024.
-
4.
Hoffmann J., Wallwiener D. Classifying breast cancer surgery: a novel, complexity-based system for oncological, oncoplastic and reconstructive procedures, and proof of principle by analysis of 1225 operations in 1166 patients. BMC Cancer. 2009;28-29.
DOI: 10.1186/1471-2407-9-108
-
5.
The International Society of Aesthetic Plastic Surgery (ISAPS). Annual Global Survey on Aesthetic/Cosmetic Procedures, 2022. Available at:https://www.isaps.org/discover/about-isaps/global-statistics/reports-and-press-releases/global-survey-2022-full-report-and-pressreleases. Accessed August 2024.
-
6.
American Society of Plastic Surgeons. 2020 Plastic Surgery Statistics Report. Available at:https://www.plasticsurgery.org/documents/News/Statistics/2020/plastic-surgerystatistics-full-report-2020.pdf. Accessed August 2024.
-
7.
Anderson D.J., Podgorny K., Berríos-Torres S.I., Bratzler D.W., Dellinger E.P. Strategies to prevent surgical site infections in acute care hospitals. Infect Control Hosp Epidemiol. 2014;35(6):605-627.
DOI: 10.1086/676022
-
8.
Global Guidelines for the Prevention of Surgical Site Infection. Geneva: World Health Organization; 2018. PMID: 30689333. Available at: https://www.who.int/publications/i/item/9789241550475. Accessed August 2024.
-
9.
Berríos-Torres S.I., Umscheid C.A., Bratzler D.W., Leas B., Stone E.C., Kelz R.R., Reinke C.E. Healthcare Infection Control Practices Advisory Committee. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg. 2017;152(8):784-791.
DOI: 10.1001/JAMASURG.2017.0904
-
10.
Fakhry S.M., Trask A.L., Waller M.A. National Institute for Health Research Global Research Health Unit on Global Surgery. Delphi prioritization and development of global surgery guidelines for the prevention of surgicalsite infection. Br J Surg. 2020;107(8):970-977.
DOI: 10.1002/BJS.11530
-
11.
Sartelli M., Coccolini F., Labricciosa F.M., Omari A.H., Bains L., Baraket O., et al. Surgical Antibiotic Prophylaxis: A Proposal for a Global Evidence-Based Bundle. Antibiotics (Basel). 2024;13(1):100.
DOI: 10.3390/ANTIBIOTICS13010100
-
12.
Ban K.A., Minei J.P., Laronga C., Harbrecht B.G., Jensen E.H., Fry D.E. Executive Summary of the American College of Surgeons/Surgical Infection Society Surgical Site Infection Guidelines-2016 Update. Surg Infect (Larchmt). 2017;18(4):379-382.
DOI: 10.1089/SUR.2016.214
-
13.
Ohge H., Mayumi T., Haji S., Kitagawa Y., Kobayashi M., Kobayashi M., Mizuguchi T., Mohri Y. Committee for Gastroenterological Surgical Site Infection Guidelines, the Japan Society for Surgical Infection. The Japan Society for Surgical Infection: guidelines for the prevention, detection, and management of gastroenterological surgical site infection, 2018. Surg Today. 2021;51(1):1-31.
DOI: 10.1007/S00595-020-02181-6
-
14.
Morikane K. Epidemiology and prevention of surgical site infection in Japan. J Hosp Infect. 2024;146:192-198.
DOI: 10.1016/J.JHIN.2023.10.027
-
15.
National Healthcare Safety Network: Surgical Site Infection Event (SSI). Center for Disease Control. 2020. Available at: https://www.cdc.gov/nhsn/PDFs/pscManual/9pscSSIcurrent.pdf?agree=yes&next=Accept. Accessed August 2024.
-
16.
Allegranzi B., Zayed B., Bischoff P., Kubilay N.Z., de Jonge S., de Vries F. WHO Guidelines Development Group. New WHO recommendations on intraoperative and postoperative measures for surgical site infection prevention: an evidence-based global perspective. Lancet Infect Dis. 2016;16(12):288-303.
DOI: 10.1016/S1473-3099(16)30402-9
-
17.
Briko N.I., Bozhkova S.A., Brusina E.B., Zhedaeva M.V. Prevention of infections in the field of surgical intervention. Methodological recommendations. Non-profit partnership «National Association of Specialists in the control of infections related to the provision of medical care» (NP «NASKI»). 2022;74. Available at: https://antimicrob.net/wp-content/uploads/2018-Profilaktika-IOKHV.pdf. Russian.
-
18.
Sattar A.K., Shahzad H., Masroor T., Martins R.S., Zahid N., Amersi F.F. Practice Patterns of Antibiotic Prophylaxis in Patients Undergoing Mastectomy: A Survey of Members of the American Society of Breast Surgeons. Ann Surg Oncol. 2022;29(10):6314-6322.
DOI: 10.1245/S10434-022-12223-7
-
19.
Chopra K., Gowda A.U., McNichols C.H., Brown E.N., Slezak S., Rasko Y. Antimicrobial Prophylaxis Practice Patterns in Breast Augmentation: A National Survey of Current Practice. Ann Plast Surg. 2017;78(6):629-632.
DOI: 10.1097/SAP.0000000000000942
-
20.
Villanueva K.G., Barr M.L., Klingbeil K.D., Tranfield W., Festekjian J. The Role of Antibiotic Prophylaxis in Primary and Secondary Implant-Based Breast Augmentation: A Systematic Review and Meta-Analysis. Ann Plast Surg. 2023;91(3):400-405.
DOI: 10.1097/SAP.0000000000003622
-
21.
Hardwicke J.T., Bechar J., Skillman J.M. Are systemic antibiotics indicated in aesthetic breast surgery? A systematic review of the literature. Plast Reconstr Surg. 2013;131(6):1395-1403.
DOI: 10.1097/PRS.0B013E31828BD752
-
22.
Khan U.D. Breast augmentation, antibiotic prophylaxis, and infection: comparative analysis of 1,628 primary augmentation mammoplasties assessing the role and efficacy of antibiotics prophylaxis duration. Aesthetic Plast Surg. 2010;34(1):42-47.
DOI: 10.1007/S00266-009-9427-8
-
23.
Ng D., Trivedi P.M., Sharma A.K., Banerjee D. Current use of antibiotic prophylaxis in breast surgery: a nationwide survey. Breast. 2007;16(1):68-72.
DOI: 10.1016/J.BREAST.2006.06.004
-
24.
Prantl L., Momeni A., Brebant V., Kuehlmann B., Heine N., Biermann N. Recommendations for the Use of Antibiotics in Primary and Secondary Esthetic Breast Surgery. Plast Reconstr Surg Glob Open. 2020;8(1):2590.
DOI: 10.1097/GOX.0000000000002590
-
25.
- Federal Law No. 492-FZ dated December 30, 2020 «On Biological Safety in the Russian Federation». Available at: https://base.garant.ru/400156868. Russian.
-
26.
Methodological guidelines "Epidemiological diagnosis of infectious diseases associated with the provision of medical care, based on standard definitions of the case." Nonprofit partnership "National Association of Specialists in the control of infections related to the provision of medical care" (NP "NASKI"). 2023;51. Available at: nasci. ru/?id=121561&download=1. Russian.
-
27.
Badia J.M., Casey A.L., Petrosillo N, Hudson P.M., Mitchell S.A. Impact of surgical site infection on healthcare costs and patient outcomes: a systematic review in six European countries. J Hosp Infect. 2017;96(1):1-15.
DOI: 10.1016/J.JHIN.2017.03.004
-
28.
Timoshevsky A.A. Infections associated with the provision of medical care (ISMP): studies.- the method. stipend. Moscow : GBU «NIIOZMM DZM». 2023;50. Available at: URL:https://niioz.ru/upload/iblock/3f3/3f3b085bed65e73d0cc6934c461770e4. Russian.
-
29.
Magill S.S., Edwards J.R., Bamberg W., Beldavs Z.G., Dumyati G, Kainer M.A. Emerging Infections Program Healthcare-Associated Infections and Antimicrobial Use Prevalence Survey Team. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370(13):1198-1208.
DOI: 10.1056/NEJMOA1306801
-
30.
Gallagher M., Jones D.J., Bell-Syer S.V. Prophylactic antibiotics to prevent surgical site infection after breast cancer surgery. Cochrane Database Syst Rev. 2019;9(9):12.
DOI: 10.1002/14651858.CD005360.PUB5
-
31.
Haley R.W., Culver D.H., Morgan W.M., White J.W. Identifying patients at high risk of surgical wound infection. A simple multivariate index of patient susceptibility and wound contamination. Am J Epidemiol. 1985;121(2):206-215.
DOI: 10.1093/OXFORDJOURNALS.AJE.A113991
-
32.
Nickel K.B., Myckatyn T.M., Lee C.N., Fraser V.J., Olsen M.A. CDC Prevention Epicenter Program. Individualized Risk Prediction Tool for Serious Wound Complications After Mastectomy With and Without Immediate Reconstruction. Ann Surg Oncol. 2022;29(12):7751-7764.
DOI: 10.1245/S10434-022-12110-1
-
33.
Strachunsky L.S., Peschere J.K., Dellinger E.P. The policy of antibiotic use in surgery, 2003. Clinical Microbiology and Antimicrobial Chemotherapy. 2003; 5(4):302-317. Russian.
DOI: 10.1245/S10434-022-12110-1
-
34.
Teija-Kaisa A., Eija M., Marja S., Outi L., et al. Risk factors for surgical site infection in breast surgery. J Clin Nurs. 2013;22(7-8):948-957.
DOI: 10.1111/JOCN.12009
-
35.
Jahkola T., Asko-Seljavaara S., von Smitten K. Immediate breast reconstruction. Scand J Surg. 2003;92(4):249-256.
DOI: 10.1177/145749690309200403
-
36.
Olsen M.A., Nickel K.B., Fox I.K. Surveillance and Prevention of Surgical Site Infections in Breast Oncologic Surgery with Immediate Reconstruction. Curr Treat Options Infect Dis. 2017;9(2):155-172.
DOI: 10.1007/S40506-017-0117-9
-
37.
Alderman A.K., Wilkins E.G., Kim H.M., Lowery J.C. Complications in postmastectomy breast reconstruction: two-year results of the Michigan Breast Reconstruction Outcome Study. Plast Reconstr Surg. 2002;109(7):2265-2274.
DOI: 10.1097/00006534-200206000-00015
-
38.
Alderman A., Gutowski K., Ahuja A., Gray D.; Postmastectomy ExpanderImplant Breast Reconstruction Guideline Work Group. ASPS clinical practice guideline summary on breast reconstruction with expanders and implants. Plast Reconstr Surg. 2014;134(4):648-655.
DOI: 10.1097/PRS.0000000000000541
-
39.
Franchelli S., Pesce M., Savaia S., Marchese A., Barbieri R., Baldelli I., De Maria A. Clinical and Microbiological Characterization of Late Breast Implant Infections after Reconstructive Breast Cancer Surgery. Surg Infect (Larchmt). 2015;16(5):636-644.
DOI: 10.1089/SUR.2014.146
-
40.
Francis S.H., Ruberg R.L., Stevenson K.B. Independent risk factors for infection in tissue expander breast reconstruction. Plast Reconstr Surg. 2009;124:1790– 1796.
DOI: 10.1097/PRS.0B013E3181BF80AA
-
41.
Hill J.L., Wong L., Kemper P. Infectious complications associated with the use of acellular dermal matrix in implant-based bilateral breast reconstruction. Ann Plast Surg. 2012;68:432–434.
DOI: 10.1097/SAP.0B013E31823B6AC6
-
42.
Kato H., Nakagami G., Iwahira Y. Risk factors and risk scoring tool for infection during tissue expansion in tissue expander and implant breast reconstruction. Breast J. 2013;19:618–626.
DOI: 10.1111/TBJ.12175
-
43.
Reish R.G., Damjanovic B., Austen W.G., Winograd J., Liao E.C., Cetrulo C.L., et al. Infection following implantbased reconstruction in 1952 consecutive breast reconstructions: salvage rates and predictors of success. Plast Reconstr Surg. 2013;131(6):1223-1230.
DOI: 10.1097/PRS.0B013E31828BD377
-
44.
Long C., Sue G.R., Chattopadhyay A., Huis In't Veld E., Lee G.K. Critical Evaluation of Risk Factors of Infection Following 2-Stage Implant-Based Breast Reconstruction. Plast Reconstr Surg Glob Open. 2017;5(7):1386.
DOI: 10.1097/GOX.0000000000001386
-
45.
Yamin F., Nouri A., McAuliffe P., Vasilakis V., Ganz J., Khan S., et al. Routine Postoperative Antibiotics After Tissue Expander Placement Postmastectomy Does Not Improve Outcome. Ann Plast Surg. 2021;87(1):28-30.
DOI: 10.1097/SAP.0000000000002826
-
46.
Sarfati I., Millochau J., Meredith I., Leroy O., Parra R.V., Romano G. Salvaging the infected breast implant: results of a retrospective series of 80 consecutive cases. J Plast Reconstr Aesthet Surg. 2020;73(12):2232-2238.
DOI: 10.1016/J.BJPS.2020.05.042
-
47.
Warren D.K., Peacock K.M., Nickel K.B., Fraser V.J., Olsen M.A. CDC Prevention Epicenter Program. Postdischarge prophylactic antibiotics following mastectomy with and without breast reconstruction. Infect Control Hosp Epidemiol. 2022;43(10):1382-1388.
DOI: 10.1017/ICE.2021.400
-
48.
Phillips B.T., Bishawi M., Dagum A.B, Khan S.U., Bui D.T. A systematic review of antibiotic use and infection in breast reconstruction: what is the evidence? Plast Reconstr Surg. 2013;131(1):1-13.
DOI: 10.1097/PRS.0B013E3182729C39
-
49.
Azouz V., Mirhaidari S., Wagner D.S. Defining Infection in Breast Reconstruction: A Literature Review. Ann Plast Surg. 2018;80(5):587-591.
DOI: 10.1097/SAP.0000000000001336
-
50.
Corcione S., Lupia T., De Rosa F.G., et al. Skin and soft tissue infections after breast surgery. Curr Opin Infect Dis. 2019;32(2):87-94.
DOI: 10.1097/QCO.0000000000000531
-
51.
Barr S.P., Topps A.R., Barnes N.L. Infection prevention in breast implant surgery: a review of the surgical evidence, guidelines and a checklist. Eur J Surg Oncol. 2016; 42:591–603.
DOI: 10.1016/J.EJSO
-
52.
Pittet B., Montandon D., Pittet D., et al. Infection in breast implants. Lancet Infect Dis. 2005;5(2):94-106.
DOI: 10.1016/S1473-3099(05)01281-8
-
53.
Zhang H.L., Cheng Y., Wang X.J. Breast Implant Infections: Clinical Microbiology, Early Diagnosis, and Antibiotic Treatment. Biomed Environ Sci. 2015;28(6):472-474.
DOI: 10.3967/BES2015.068
-
54.
Boustany A.N., Elmaraghi S., Agochukwu N., Cloyd B., Dugan A.J., Rinker B. A breast prosthesis infection update: Two-year incidence, risk factors and management at single institution. Indian J Plast Surg. 2018;51(1):7-14.
DOI: 10.4103/IJPS.IJPS_215_17
-
55.
Cohen J.B., Carroll C., Tenenbaum M.M., Myckatyn T.M. Breast Implant-Associated Infections: The Role of the National Surgical Quality Improvement Program and the Local Microbiome. Plast Reconstr Surg. 2015;136(5):921-929.
DOI: 10.1097/PRS.0000000000001682
-
56.
Mesa F., Cataño S., Tuberquia O., et al. Study of Infections in Breast Augmentation Surgery with Implants in 9,691 Patients over 5 Years. Plast Reconstr Surg Glob Open. 2021;9(8):3752.
DOI: 10.1097/GOX.0000000000003752
-
57.
Hu Y., Zhou X., Tong X., Chen X., Wang M. Postoperative antibiotics and infection rates after implant-based breast reconstruction: A systematic review and metaanalysis. Front Surg. 2022;17:92.
DOI: 10.3389/FSURG.2022.926936
-
58.
Bartsich S., Ascherman J.A., Whittier S, Yao C.A., Rohde C. The breast: a clean-contaminated surgical site. Aesthet Surg J. 2011;31(7):802-806.
DOI: 10.1177/1090820X11417428
-
59.
Kataria K., Bagdia A., Srivastava A. Are Breast Surgical Operations Clean or Clean Contaminated? Indian J Surg. 2015;77(3):1360-1362.
DOI: 10.1007/S12262-015-1252-5
-
60.
Alam B., Akbari A.R., Alali B., Thankan E., Ekhlacy S., et al. Antibiotic prophylaxis in breast surgery: a meta-analysis to identify the optimal strategy to reduce infection rates in breast surgery. Breast Cancer. 2022;29(6):945-956.
DOI: 10.1007/S12282-022-01387-5
-
61.
Hu Y., Mao Z., Xu Y., et al. Comprehensive analysis of risk factors for postoperative wound infection following radical mastectomy in breast cancer patients. Int Wound J. 2024;21(4):14848.
DOI: 10.1111/IWJ.14848
-
62.
Degnim A.C., Throckmorton A.D., Boostrom S.Y., Boughey J.C. Surgical site infection after breast surgery: impact of 2010 CDC reporting guidelines. Ann Surg Oncol. 2012;19(13):4099-4103.
DOI: 10.1245/S10434-012-2448-6
-
63.
Zapata-Copete J., Aguilera-Mosquera S., García-Perdomo H.A., et al. Antibiotic prophylaxis in breast reduction surgery: A systematic review and meta-analysis. J Plast Reconstr Aesthet Surg. 2017;70(12):1689-1695.
DOI: 10.1016/J.BJPS.2017.08.005
-
64.
Lalani T. Breast Implant Infections: An Update. Infect Dis Clin North Am. 2018;32(4):877-884.
DOI: 10.1016/J.IDC.2018.06.007
-
65.
Agarwal N., Agarwal S.K., Bhattacharya S., Datta S.S., Chatterjee S., Ahmed R. Antibiotic Prophylaxis for Breast Oncosurgery in a Setting With a High Prevalence of Multidrug-Resistant Bacteria: Common Sense Infection Control Measures Are More Important Than Prolonged Antibiotics. Infect Control Hosp Epidemiol. 2018;39(4):498-500.
DOI: 10.1017/ICE.2017.313
-
66.
Phillips B.T., Fourman M.S., Bishawi M., Zegers M., O'Hea B.J. Are Prophylactic Postoperative Antibiotics Necessary for Immediate Breast Reconstruction? Results of a Prospective Randomized Clinical Trial. J Am Coll Surg. 2016;222(6):1116-1124.
DOI: 10.1016/J.JAMCOLLSURG.2016.02.018
-
67.
Olsen M.A., Lefta M., Dietz J.R., Brandt K.E., Aft R., Matthews R. Risk factors for surgical site infection after major breast operation. J Am Coll Surg. 2008;207(3):326-335.
DOI: 10.1016/J.JAMCOLLSURG.2008.04.021
-
68.
Xue D.Q., Qian C., Yang L., Wang X.F., et al. Risk factors for surgical site infections after breast surgery: a systematic review and meta-analysis. Eur J Surg Oncol. 2012;38(5):375-381.
DOI: 10.1016/J.EJSO.2012.02.179
-
69.
Theocharidis V., Katsaros I., Sgouromallis E., Serifis N., Boikou V., Tasigiorgos S., Kokosis G., et al. Current evidence on the role of smoking in plastic surgery elective procedures: A systematic review and meta-analysis. J Plast Reconstr Aesthet Surg. 2018;71(5):624-636.
DOI: 10.1016/J.BJPS.2018.01.011
-
70.
Szymankiewicz M., Nowikiewicz T., Biedka M. Significance of Infections in Implant Loss After Breast Reconstruction in the Course of Breast Cancer Treatment. Pol J Microbiol. 2019;68(3):343-351.
DOI: 10.33073/PJM-2019-037
-
71.
Pastoriza J., McNelis J., Parsikia A., Lewis E., Ward M., Marini C.P., et al. Predictive Factors for Surgical Site Infections in Patients Undergoing Surgery for Breast Carcinoma. Am Surg. 2021;87(1):68-76.
DOI: 10.1177/0003134820949996
-
72.
Baker N.F., Brown O., Hart A.M., Danko D., Stewart C.M., Thompson P.W. Preventing Infection in Implant-based Breast Reconstruction: Evaluating the Evidence for Common Practices and Standardized Protocols. Plast Reconstr Surg Glob Open. 2022;10(3):4208.
DOI: 10.1097/GOX.0000000000004208
-
73.
Li R., Ranganath B. In hospital outcomes of autologous and implant-based breast reconstruction in patients with diabetes mellitus: A population-based study of 2015-2020 national inpatient sample. World J Surg. 2024;48(4):903-913.
DOI: 10.1002/WJS.12136
-
74.
Bağhaki S., Soybir G.R., Soran A. Guideline for Antimicrobial Prophylaxis in Breast Surgery. J Breast Health. 2014;10(2):79-82.
DOI: 10.5152/TJBH.2014.1959
-
75.
Seng P., Bayle S., Alliez A., Romain F., Casanova D., Stein A. The microbial epidemiology of breast implant infections in a regional referral centre for plastic and reconstructive surgery in the south of France. Int J Infect Dis. 2015;35:62-66.
DOI: 10.1016/J.IJID.2015.04.010
-
76.
Palubicka A., Jaworski R., Wekwejt M., Swieczko-Zurek B., Pikula M., Jaskiewicz J. Surgical Site Infection after Breast Surgery: A Retrospective Analysis of 5-Year Postoperative Data from a Single Center in Poland. Medicina (Kaunas). 2019;55(9):512.
DOI: 10.3390/MEDICINA55090512
-
77.
Lohmeyer J.A., Jakob V.L., Keck M., Wittig K., et al. Antibiotic treatment and prophylaxis of periprosthetic infections: Evaluation of 666 consecutive breast implant removals. J Plast Reconstr Aesthet Surg. 2021;74(7):1486-1494.
DOI: 10.1016/J.BJPS.2020.11.005
-
78.
Schoberleitner I., Baier L., Lackner M., Zenz L.M., CoraçaHuber D.C., Ullmer W., et al. Surface Topography, Microbial Adhesion, and Immune Responses in Silicone Mammary Implant-Associated Capsular Fibrosis. Int J Mol Sci. 2024;25(6):3163.
DOI: 10.3390/IJMS25063163
-
79.
Feldman E.M., Kontoyiannis D.P., Sharabi S.E., Lee E., Kaufman Y., Heller L. Breast implant infections: is cefazolin enough? Plast Reconstr Surg. 2010;126(3):779-785.
DOI: 10.1097/PRS.0B013E3181E5F7FF
-
80.
Throckmorton A. D., Baddour L. M., Hoskin T. L., Boughey J. C., Degnim A. C. Microbiology of surgical site infections complicating breast surgery. Surgical Infections. 2010;11(4):355–359.
DOI: 10.1089/SUR.2009.029
-
81.
Crawford C.B., Clay J.A., Seydel A.S., Wernberg J.A. Surgical Site Infections in Breast Surgery: The Use of Preoperative Antibiotics for Elective, Nonreconstructive Procedures. Int J Breast Cancer. 2016;23:92.
DOI: 10.1155/2016/1645192
-
82.
Reish R.G., Damjanovic B., Austen W.G, Winograd J., Liao E.C., Cetrulo C.L. Infection following implant-based reconstruction in 1952 consecutive breast reconstructions: salvage rates and predictors of success. Plast Reconstr Surg. 2013;131(6):1223-1230.
DOI: 10.1097/PRS.0B013E31828BD377
-
83.
Weichman K.E., Levine S.M., Wilson S.C., Choi M., Karp N.S. Antibiotic selection for the treatment of infectious complications of implant-based breast reconstruction. Ann Plast Surg. 2013;71(2):140-143.
DOI: 10.1097/SAP.0B013E3182590924
-
84.
Rey J.E., Gardner S.M., Cushing R.D., et al. Determinants of surgical site infection after breast biopsy. Am J Infect Control. 2005;33(2):126-129.
DOI: 10.1016/J.AJIC.2004.05.004
-
85.
Franchelli S., Vassallo F., Porzio C., Mannucci M., Priano V., Schenone E., at al. Breast implant infections after surgical reconstruction in patients with breast cancer: assessment of risk factors and pathogens over extended post-operative observation. Surg Infect (Larchmt). 2012;13(3):154-158.
DOI: 10.1089/SUR.2011.004
-
86.
Papanicolas L.E., Gordon D.L., Wesselingh S.L., Rogers G.B. Not Just Antibiotics: Is Cancer Chemotherapy Driving Antimicrobial Resistance? Trends Microbiol. 2018;26(5):393-400.
DOI: 10.1016/J.TIM.2017.10.009
-
87.
Meunier A., Nerich V., Fagnoni-Legat C., Richard M., Mazel D., Adotevi O., et al. Enhanced emergence of antibiotic-resistant pathogenic bacteria after in vitro induction with cancer chemotherapy drugs. J Antimicrob Chemother. 2019;74(6):1572-1577.
DOI: 10.1093/JAC/DKZ070
-
88.
Aitken S.L., Sahasrabhojane P.V., Kontoyiannis D.P., Savidge T.C. Alterations of the Oral Microbiome and Cumulative Carbapenem Exposure Are Associated With Stenotrophomonas maltophilia Infection in Patients With Acute Myeloid Leukemia Receiving Chemotherapy. Clin Infect Dis. 2021;72(9):1507-1513.
DOI: 10.1093/CID/CIAA778
-
89.
Macadam S.A., Mehling B.M., Fanning A., Dufton J.A., Kowalewska-Grochowska K.T., Lennox P., et al. Nontuberculous mycobacterial breast implant infections. Plast Reconstr Surg. 2007;119(1):337-344.
DOI: 10.1097/01.PRS.0000244924.61968.D2
-
90.
Washer L.L., Gutowski K. Breast implant infections. Infect Dis Clin North Am. 2012;26(1):111-215.
DOI: 10.1016/J.IDC.2011.09.003
-
91.
Thomas M., D'Silva J.A., Borole A.J., Chilgar R.M. Periprosthetic atypical mycobacterial infection in breast implants: a new kid on the block! J Plast Reconstr Aesthet Surg. 2013;66(1):16-19.
DOI: 10.1016/J.BJPS.2012.09.028
-
92.
Romero F.A., Powell E.A., Babady N.E., Kaltsas A., Figueroa C.J., Pulitzer M. Nontuberculous Mycobacterial Infections After Silicone Breast Implant Reconstruction Emphasize a Diversity of Infecting Mycobacteria. Open Forum Infect Dis. 2017;4(4):189.
DOI: 10.1093/OFID/OFX189
-
93.
Zhang R., Singh D., Parsa F.D. Review of Early Signs of Breast Implant Infection. Aesthetic Plast Surg. 2022;46(5):2152-2158.
DOI: 10.1007/S00266-021-02702-9
-
94.
Al-Halabi B., Viezel-Mathieu A., Shulman Z., Behr M.A., Fouda Neel O. Breast Implant Mycobacterial Infections: An Epidemiologic Review and Outcome Analysis. Plast Reconstr Surg. 2018;142(5):639-652.
DOI: 10.1097/PRS.0000000000004892
-
95.
Kuzmenkov A.Yu., Vinogradova A.G., Trushin I.V., Edelstein M.V., Avramenko A.A., Dekhnich A.V. AMRmap – antibiotic resistance surveillance system in Russia. Clinical microbiology and antimicrobial chemotherapy. 2021;23(2):198-204. Russian.
DOI: 10.36488/CMAC.2021.2.198-204
-
96.
Scottish Intercollegiate Guidelines Network. Antibiotic Prophylaxis in Surgery, A National Clinical Guideline. Edinburgh. 2024 Available at: http://medicinainterna.net.pe/images/guias/GUIA_PARA_LA_PROFILAXIS_ANTIBIOTICA_EN_CIRUGIA.pdf. Accessed August 2024.
-
97.
Kuhnen R.B., Sabino Neto M, Souza L.V., Ferreira L.M., Veiga D.F. Antibiotic Prophylaxis in Reduction Mammaplasty: A National Survey. Aesthetic Plast Surg. 2022;46(5):2124-2130.
DOI: 10.1007/s00266-022-02903-w
-
98.
The American Society of Breast Surgeons. Consensus Guideline on Preoperative Antibiotics and Surgical Site Infection in Breast Surgery; The American Society of Breast Surgeons: Columbia, MD, USA, 2017; Available at: https://www.breastsurgeons.org/docs/statements/Consensus-Guideline-on-Preoperative-Antibiotics-andSurgical-Site-Infection-in-Breast-Surgery.pdf. Accessed August 2024.
-
99.
American Society of Plastic Surgeons. Evidence-Based Clinical Practice Guidelines; American Society of Plastic Surgeons: Arlington Heights, IL, USA, 2019; Available at: https://www.plasticsurgery.org/for-medicalprofessionals/quality/evidence-based-clinical-practiceguidelines. Accessed August 2024.
-
100.
Zuzova A.P., Belkova Yu.A. Infections in the field of surgical intervention: general approaches to antibiotic prophylaxis and therapy. Pharmateca. 2007; 4: 67-74. Russian.
-
101.
Estrela, Y.d.C.A., Oliveira, I.d.S., Ferreira S.B. Management of Antibiotic Prophylaxis in Mastectomy and Mammoplasty Procedures. Med. Sci. 2024. Available at:https://doi.org/10.3390/ECA2023-16396. Accessed August 2024.
-
102.
Platt R., Zucker J.R., Zaleznik D.F., Hopkins C.C., Dellinger E.P., Karchmer A.W. Perioperative antibiotic prophylaxis and wound infection following breast surgery. J Antimicrob Chemother. 1993;31:43-48.
DOI: 10.1093/jac/31.suppl_b.43
-
103.
Tejirian T., DiFronzo L.A., Haigh P.I. Antibiotic prophylaxis for preventing wound infection after breast surgery: a systematic review and metaanalysis. J Am Coll Surg. 2006;203(5):729-734.
DOI: 10.1016/j.jamcollsurg.2006.07.013
-
104.
Sajid M.S., Hutson K., Akhter N., Kalra L., Rapisarda I.F., Bonomi R. An updated meta-analysis on the effectiveness of preoperative prophylactic antibiotics in patients undergoing breast surgical procedures. Breast J. 2012;18(4):312-317.
DOI: 10.1111/j.1524-4741.2012.01248.x
-
105.
Shortt R., Cooper M.J., Farrokhyar F., Bain J., et al. Metaanalysis of antibiotic prophylaxis in breast reduction surgery. Plast Surg (Oakv). 2014;22(2):91-94.
DOI: 10.1111/j.1524-4741.2012.01248
-
106.
Ariyan S., Martin J., Lal A., Cheng D., Borah G.L., Chung K.C. Antibiotic prophylaxis for preventing surgicalsite infection in plastic surgery: an evidence-based consensus conference statement from the American Association of Plastic Surgeons. Plast Reconstr Surg. 2015;135(6):1723-1739.
DOI: 10.1097/PRS.0000000000001265
-
107.
Guo T., Chen B., Rao F., Wu P., Liu P., Liu Z., et al. Identifying the superior antibiotic prophylaxis strategy for breast surgery: A network meta-analysis. Medicine (Baltimore). 2019;98(17):15405.
DOI: 10.1097/MD.0000000000015405
-
108.
Seretis K., Bounas N., Papaspyrou F. Antibiotic Prophylaxis in Reduction Mammaplasty: A Network Meta-Analysis. Aesthetic Plast Surg. 2023;47(3):1009-1017.
DOI: 10.1007/s00266-023-03313-2
-
109.
Jin L., Ba T. Effect of prolonged antibiotic prophylaxis on the occurrence of surgical site wound infection after instant breast reconstruction: A meta-analysis. Int Wound J. 2024;21(4):14631.
DOI: 10.1111/iwj.14631
-
110.
Yakovlev S. V. High-tech perioperative immunoprophylaxis in the context of the surgical concept of Fast Track. Anesthesiology and intensive care. Medical rehabilitation. 2016;12(129):43-48. Russian.
-
111.
Andreeva I.V., Stetsiouk O.U., Kozlov R.S. Antibiotic dosing in obesity: size does matter? Clinical microbiology and antimicrobial chemotherapy. 2017;19(3):214-228. Russian.
-
112.
Duell C.H., O'Sullivan D.M., Bilinskaya A., Linder K.E. Evaluation of Timing of Antimicrobial Surgical Prophylaxis on Rates of Surgical Site Infections. Surg Infect (Larchmt). 2024.12:24.
DOI: 10.1089/sur.2024.010
-
113.
Jonge S.W., Boldingh Q.J., Koch A.H. Timing of Preoperative Antibiotic Prophylaxis and Surgical Site Infection: TAPAS, An Observational Cohort Study Ann Surg. 2021;274(4):308-314.
DOI: 10.1097/SLA.0000000000003634
-
114.
Avashia Y.J., Mohan R., Berhane C., Oeltjen J.C. Postoperative antibiotic prophylaxis for implant-based breast reconstruction with acellular dermal matrix. Plast Reconstr Surg. 2013;131(3):453-461.
DOI: 10.1097/PRS.0b013e31827c6d90
-
115.
Clayton J.L., Bazakas A, Lee C.N., Hultman C.S., Halvorson E.G. Once is not enough: withholding postoperative prophylactic antibiotics in prosthetic breast reconstruction is associated with an increased risk of infection. Plast Reconstr Surg. 2012;130(3):495-502.
DOI: 10.1097/PRS.0b013e31825dbefe
-
116.
Mazari F., Wattoo G.M., Kazzazi N.H., Kolar K.M., Olubowale O.O., Rogers C.E. Prophylactic antibiotic use in acellular dermal matrix-assisted implant-based breast reconstruction. Ann R Coll Surg Engl. 2021;103(3):186-190.
DOI: 10.1308/rcsann.2020.7017
-
117.
Hai Y., Chong W., Lazar M.A. Extended Prophylactic Antibiotics for Mastectomy with Immediate Breast Reconstruction: A Meta-analysis. Plast Reconstr Surg Glob Open. 2020;8(1):2613.
DOI: 10.1097/GOX.0000000000002613
-
118.
Rijkx M.E.P., Klein D.O., Hommes J.E., van Mens S.P., van Kuijk S., Heuts E.M. Evidence for the use of periand post-operative antibiotic prophylaxis in autologous breast reconstruction: A systematic review. J Plast Reconstr Aesthet Surg. 2023;83:404-414.
DOI: 10.1016/j.bjps.2023.04.038
-
119.
Hsieh H.H., Liu P.H., Chang C.J., Kuo Y.L., Chang T.Y. Effectiveness of extended antibiotic prophylaxis in implantbased breast reconstruction surgery: A meta-analysis. J Plast Reconstr Aesthet Surg. 2024;95:368-376.
DOI: 10.1016/j.bjps.2024.04.057
-
120.
Gahm J., Ljung Konstantinidou A., Lagergren J., Sandelin K., Glimåker M., Johansson H. Effectiveness of Single vs Multiple Doses of Prophylactic Intravenous Antibiotics in Implant-Based Breast Reconstruction: A Randomized Clinical Trial. JAMA Netw Open. 2022;5(9):223.
DOI: 10.1001/jamanetworkopen.2022.31583
-
121.
Huang N., Liu M., Yu P., Wu J. Antibiotic prophylaxis in prosthesis-based mammoplasty: a systematic review. Int J Surg. 2015;15:31-37.
DOI: 10.1016/j.ijsu.2015.01.020
-
122.
Chidester J.R., Danci I., Lewis P., Biskup N., Kim H., Gupta S. Antibiogram for Periprosthetic Infections: A Tool for Better Informed Selection of Empiric Antibiotics for Surgical Site Infections. Ann Plast Surg. 2016;76(3):158-161.
DOI: 10.1097/SAP.0000000000000803
-
123.
Berríos-Torres S.I., Umscheid C.A., Bratzler D.W., Leas B., Stone E.C., Kelz R.R., et al. Healthcare Infection Control Practices Advisory Committee. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg. 2017;152(8):784-791.
DOI: 10.1001/jamasurg.2017.0904
-
124.
Shafi H., Seah J., Purnima P., Patun T., Kam K.Q. National surgical antibiotic prophylaxis guideline in Singapore. Ann Acad Med Singap. 2022;51(11):695-711.
DOI: 10.47102/annals-acadmedsg.2022273
-
125.
Resolution of the Chief State Sanitary Doctor of the Russian Federation dated 01/28/2021 No. 4 (as amended on 05/25/2022) «On approval of sanitary rules and norms SanPiN 3.3686-21 «Sanitary and epidemiological requirements for the prevention of infectious diseases» (together with «SanPiN 3.3686-21. Sanitary rules and regulations…») (Registered with the Ministry of Justice of the Russian Federation on 02/15/2021 No. 62500. Available at: https://docs.cntd.ru/document/573660140). Russian.
-
126.
South Australian expert Advisory Group on Antimicrobial Resistance (SAAGAR). Surgical Antimicrobial Prophylaxis Clinical Guideline v3.0. ISBN: 978-1-76083-441-8. 2021. Available at: https://www.sahealth.sa.gov.au/wps/wcm/connect/6bb523804358edbd883b9ef2cadc00ab/Surgical+Prophylaxis+guideline+FINAL_obesity+amendment2023.pdf?MOD=AJPERES&CACHEID=ROOTWORKSPACE-6bb523804358edbd883b9ef2cadc00aboJaZWl7. Accessed August 2024.
-
127.
Dellinger E.P. Approach to the patient with postoperative fever. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, Ann Acad Med Singap. 2004;51(11):695-711.
DOI: 10.47102/annals-acadmedsg.2022273
-
128.
Stevens D.L., Bisno A.L., Chambers H.F., Dellinger E.P., Goldstein E.J. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America. Clin Infect Dis. 2014;59(2):147-159.
DOI: 10.1093/cid/ciu296
-
129.
Stetsiouk O.U., Andreeva I.V. Modern principles of antibacterial therapy of severe and life-threatening bacterial infections. Pharmateca. 2008;(4):12-17. Russian.
DOI: 10.1086/519472
-
130.
Beloborodov V.B., Gusarov V.G., Dekhnich А.V., Zamyatin M.N., Zubareva N.А., Zyryanov S.K., et al. Diagnostics and antimicrobial therapy of the infections caused by multiresistant microorganisms. Guidelines of the Association of Anesthesiologists-Intensivists, the Interregional Non-Governmental Organization Alliance of Clinical Chemotherapists and Microbiologists, the Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC), and NGO Russian Sepsis Forum. Messenger of Anesthesiology and Resuscitation, 2020; 17(1):52-83. Russian.
DOI: 10.21292/2078-5658-2020-17-1-52-83.
-
131.
Portal of general information resources and open data. General characteristics of the drug Vancoter-AF. Available at: https://lk.regmed.ru/Register/EAEU_SmPC. Accessed October 29, 2024. Russian.
-
132.
Shea K.W., Cunha B.A. Teicoplanin. Med Clin North Am. 1995;79(4):833-844.
DOI: 10.1016/s0025-7125(16)30042-6
-
133.
Stetsiouk O.U., Reshedko G.K., Andreeva I.V. Linezolid: place in the therapy of infections caused by resistant grampositive pathogens. Pharmateka. 2006;14(129):31-36. Russian.
-
134.
Bradley J.D., Nelson J.D. 2024 Nelson’s Pediatric Antimicrobial Therapy, 30th Edition. 2024:384. Available at: https://www.aap.org/2024-Nelsons-PediatricAntimicrobial-Therapy-30th-Edition-Paperback. Accessed August 2024.
-
135.
Instructions for the medical use of the drug Zinforo. Available at: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGuid=d8f547d1-e210-455f-aa40-1e29b89d43e1&t=. Russian.
-
136.
Anderson D.J., Sexton D.J., Kanafani Z.A., Auten G., Kaye K.S. Severe surgical site infection in community hospitals: epidemiology, key procedures, and the changing prevalence of methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol. 2007;28(9):1047-1053.
DOI: 10.1086/520731
-
137.
Domínguez-Herrera J., López-Rojas R., Smani Y., LabradorHerrera G., Pachón J. Efficacy of ceftaroline versus vancomycin in an experimental foreign-body and systemic infection model caused by biofilm-producing methicillinresistant Staphylococcus epidermidis. Int J Antimicrob Agents. 2016;48(6):661-665.
DOI: 10.1016/j.ijantimicag.2016.09.011
-
138.
Siciliano V., Passerotto R.A., Chiuchiarelli M., Leanza G.M., Ojetti V. Difficult-to-Treat Pathogens: A Review on the Management of Multidrug-Resistant Staphylococcus epidermidis. Life (Basel). 2023;13(5):1126.
DOI: 10.3390/life13051126
-
139.
Sakoulas G., Moise P.A., Casapao A.M., Nonejuie P., Olson J., Okumura C.Y., et al. Antimicrobial Salvage Therapy for Persistent Staphylococcal Bacteremia Using Daptomycin Plus Ceftaroline. Clin. Ther. 2014;36:1317-1333.
DOI: 10.1016/j.clinthera.2014.05.061
-
140.
Dekhnich А.V., Zubareva N.А., Kozlov R.S., Popov D.А., Romanov A.V. Telavancin – New Antimicrobial Active Against Multiresistant Gram-Positive Pathogens. Clinical and Microbiological Features in Questions and Answers. Clinical microbiology and antimicrobial chemotherapy. 2015; 17(2):127-145. Russian.
-
141.
Gander S., Kinnaird A., Finch R. Telavancin: in vitro activity against Staphylococci in a biofilm model. J Antimicrob Chemother. 2005;56(2):337-343.
DOI: 10.1093/jac/dki198
-
142.
LaPlante K.L., Mermel L.A. In vitro activities of telavancin and vancomycin against biofilm-producing Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis strains. Antimicrob Agents Chemother. 2009;53(7):3166-3169.
DOI: 10.1128/AAC.01642-08
-
143.
Andreeva I.V., Stetsyuk O.U., Kozlov R.S. Tigecycline: prospects of application in clinical practice. Clinical microbiology and antimicrobial chemotherapy. 2010;12(2):127–145. Russian.
-
144.
Dekhnich A.V., Danilov A.I. Daptomycin: a review of pharmacological, clinical and microbiological parameters. Clinical Microbiology and Antimicrobial Chemotherapy, 2010; 12:4:295-313. Russian.
DOI: 10.2174/1389557511209030202
-
145.
Belkova J.A. Role of fusidic acid in clinical practice. Clinical Microbiology and Antimicrobial Chemotherapy, 2001; 3(4):324-338. Russian.
-
146.
Franchelli S., Pesce M., Baldelli I., Marchese A., Santi P., De Maria A., et al. Analysis of clinical management of infected breast implants and of factors associated to successful breast pocket salvage in infections occurring after breast reconstruction. Int J Infect Dis. 2018;71:67-72.
DOI: 10.1016/j.ijid.2018.03.019
-
147.
Ota D., Fukuuchi A., Iwahira Y., Kato T., Takeuchi M., Okamoto J., Nishi T. Identification of complications in mastectomy with immediate reconstruction using tissue expanders and permanent implants for breast cancer patients. Breast Cancer. 2016;23(3):400-406.
DOI: 10.1007/s12282-014-0577-4
-
148.
Viola G.M., Selber J.C., Crosby M., Raad I.I., Butler C.E. Salvaging the Infected Breast Tissue Expander: A Standardized Multidisciplinary Approach. Plast Reconstr Surg Glob Open. 2016;4(6):732.
DOI: 10.1097/GOX.0000000000000676
-
149.
Bennett S.P., Fitoussi A.D., Berry M.G., Couturaud B., Salmon R.J. Management of exposed, infected implantbased breast reconstruction and strategies for salvage. J Plast Reconstr Aesthet Surg. 2011;64(10):1270-1277.
DOI: 10.1016/j.bjps.2011.05.009
-
150.
Spear S.L., Seruya M. Management of the infected or exposed breast prosthesis: a single surgeon's 15-year experience with 69 patients. Plast Reconstr Surg. 2010;125(4):1074-1084.
DOI: 10.1097/PRS.0b013e3181d17fff
-
151.
Yeo H., Lee D., Kim J.S., Eo P.S., Kim D.K. Strategy for salvaging infected breast implants: lessons from the recovery of seven consecutive patients. Arch Plast Surg. 2021;48(2):165-174.
DOI: 10.5999/aps.2020.01578
-
152.
Privolnev V.V., Zubareva N.А., Karakulina Е.V. Topical therapy of wound infections: antiseptics or antibiotics? Clinical microbiology and antimicrobial chemotherapy. 2017; 19(2):131-138. Russian.
-
153.
Kuzin M.I., Kostjuchenok B.M. Wounds and wound infection.1990;130-134. Russian.
-
154.
Cooper M. The cytotoxic effects of commonly used topical antibacterial agents on human fibroblasts and keratinocytes. J Trauma. 1991;1:782-784.
DOI: 10.1097/00005373-199106000-00007
-
155.
Fromm-Dornieden C., Rembe J.D., Schäfer N., Böhm J., Stuermer E.K. Cetylpyridinium chloride and miramistin as antiseptic substances in chronic wound management – prospects and limitations. J Med Microbiol. 2015;64(Pt 4):407-414.
DOI: 10.1099/jmm.0.000034
-
156.
Ziryanov S.K. Clinical and pharmacological analysis of the application of antiseptic drugs in practical medicine. Pharmacology & Pharmacotherapy. 2022;(1):10-24. Russian.
DOI: 10.46393/ 27132129_2022_1_10
-
157.
Golub A.V., Privol’nev V.V. Topical Antibacterial Therapy For Surgical Skin And Soft Tissue Infections In Outpatient Settings: Summands Of Success. Rany i ranevye infekcii 2014;1(1):33-39. Russian.
-
158.
Wesgate R., Evangelista C., Atkinson R., Shepard A., Adegoke O., Maillard J.Y. Understanding the risk of emerging bacterial resistance to over the counter antibiotics in topical sore throat medicines. J Appl Microbiol. 2020;129(4):916-925.
DOI: 10.1111/jam.14682
-
159.
Privol’nev V.V., Pashalova Ju.S., Rodin A.V. Topical Treatment of Wounds and Wound Infection: Results of Anonymous Surgeons Questioning. Clinical Microbiology and Antimicrobial Chemotherapy. 2016; 18(2):152-158. Russian.
-
160.
Bessa G.R., Quinto V.P., Machado D.C., Lipnharski C., Weber M.B. Staphylococcus aureus resistance to topical antimicrobials in atopic dermatitis. An Bras Dermatol. 2016;91(5):604-610.
DOI: 10.1590/abd1806-4841.20164860
-
161.
Bel’kova J.A. Efficacy of Topical Combination of Bacitracin and Neomycin vs. Chloramphenicol in the Treatment of Uncomplicated Mild to Moderate Surgical Skin and Soft Tissue Infections in Adult Out-patients. Clinical Microbiology and Antimicrobial Chemotherapy. 2013;15(2):131-142. Russian.