Disseminated Mycobacterium genavense infection in an otherwise healthy child: a clinical case and literature review | CMAC

Disseminated Mycobacterium genavense infection in an otherwise healthy child: a clinical case and literature review

Clinical Microbiology and Antimicrobial Chemotherapy. 2023; 25(4):358-365

​ Dolgopolov I.S., Zaitseva A.V., Khamtsova Zh.V., Ivanova A.V., Tsvetkova E.O.
10.36488/cmac.2023.4.358-365
atypical mycobacteriosis Mycobacterium genavense children diagnosis mass spectrometry antibiotics
Section
Diseases and Pathogens
Type
Clinical Case
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2023; 25(4):358-365

Abstract

This paper presents the first clinical case of combined pulmonary and abdominal M. genavense infection in an otherwise healthy, immunocompetent child with an early treatment response and full recovery. The favorable outcome was determined by rapid microbiological diagnosis using up-to-date diagnostic methods followed by targeted antimicrobial therapy.

Igor S. Dolgopolov

Children’s Regional Clinical Hospital, Tver, Russia
Tver State Medical University, Tver, Russia

Zaitseva A.V.

Children’s Regional Clinical Hospital, Tver, Russia

Khamtsova Zh.V.

V.P. Avaev Center for Specialized Types of Medical Care, Tver, Russia

Ivanova A.V.

Children’s Regional Clinical Hospital, Tver, Russia

Tsvetkova E.O.

Children’s Regional Clinical Hospital, Tver, Russia

  • 1. Böttger E.C., Teske A., Kirschner P., Bost S., Chang H.R., Beer V., Hirschel B. Disseminated “Mycobacterium genavense” infection in patients with AIDS. Lancet. 1992;340(8811):76-80. DOI: 10.1016/0140-6736(92)90397-l
  • 2. Hillebrand-Haverkort M.E., Kolk A.H., Kox L.F., Ten Velden J.J., Ten Veen J.H. Generalized Mycobacterium genavense infection in HIV-infected patients: detection of the mycobacterium in hospital tap water. Scand J Infect Dis. 1999;31(1):63-68. DOI: 10.1080/00365549950161907
  • 3. Schmitz A., Korbel R., Thiel S., Wörle B., Gohl C., Rinder M. High prevalence of Mycobacterium genavense within flocks of pet birds. Vet Microbiol. 2018;218:40-44. DOI: 10.1016/j.vetmic.2018.03.026
  • 4. Mahmood M., Ajmal S., Abu Saleh O.M., Bryson A., Marcelin J.R., Wilson J.W. Mycobacterium genavense infections in non-HIV immunocompromised hosts: a systematic review. Infect Dis (Lond). 2018;50(5):329-339. DOI: 10.1080/23744235.2017.1404630
  • 5. Portaels F., Realini L., Bauwens L., Hirschel B., Meyers W.M., de Meurichy W. Mycobacteriosis caused by Mycobacterium genavense in birds kept in a zoo: 11-year survey. J Clin Microbiol. 1996;34(2):319-323. DOI: 10.1128/jcm.34.2.319-323.1996
  • 6. Dumonceau J.M., Fonteyne P.A., Realini L., Van Gossum A., Van Vooren J.P., Portaels F. Species-specific Mycobacterium genavense DNA in intestinal tissues of individuals not infected with human immunodeficiency virus. J Clin Microbiol. 1995;33(9):2514-2515. DOI: 10.1128/jcm.33.9.2514-2515.1995
  • 7. Santos M., Gil-Brusola A., Escandell A., Blanes M., Gobernado M. Mycobacterium genavense infections in a tertiary hospital and reviewed cases in non-HIV patients. Patholog Res Int. 2014;2014:371370. DOI: 10.1155/2014/371370
  • 8. Charles P., Lortholary O., Dechartres A., Doustdar F., Viard J.P., Lecuit M., Gutierrez M.C.; French Mycobacterium genavense Study Group. Mycobacterium genavense infections: a retrospective multicenter study in France, 1996-2007. Medicine (Baltimore). 2011;90(4):223-230. DOI: 10.1097/MD.0b013e318225ab89
  • 9. Baldolli A., Chocron R., Dargère S., Michon J., Daurel C., Thuillier-Lecouf A., Verdon R. Mycobacterium genavense infections in immunocompromised patients without HIV: case series of solid organ transplant patients and literature review. Open Forum Infect Dis. 2022;9(10):ofac498. DOI: 10.1093/ofid/ofac498
  • 10. Tangye SG, Al-Herz W, Bousfiha A, Chatila T, Cunningham-Rundles C, Etzioni A, et al. Human inborn errors of immunity: 2019 update on the classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol. 2020;40(1):24-64. DOI: 10.1007/s10875-019-00737-x
  • 11. Ombelet S., Van Wijngaerden E., Lagrou K., Tousseyn T., Gheysens O., Droogne W., et al. Mycobacterium genavense infection in a solid organ recipient: a diagnostic and therapeutic challenge. Transpl Infect Dis. 2016;18(1):125-131. DOI: 10.1111/tid.12493
  • 12. Cobos-Carrascosa E., Martin-Nalda A., Alvarez M., Segarra O., Frick M.A., Soler-Palacin P. Protein-losing enteropathy in an HIV-infected pediatric patient with previous disseminated Mycobacterium genavense infection. AIDS. 2015;29(6):745-746. DOI: 10.1097/QAD.0000000000000568
  • 13. Hoefsloot W., van Ingen J., Peters E.J., Magis-Escurra C., Dekhuijzen P.N., Boeree M.J., van Soolingen D. Mycobacterium genavense in the Netherlands: an opportunistic pathogen in HIV and non-HIV immunocompromised patients. An observational study in 14 cases. Clin Microbiol Infect. 2013;19(5):432-437. DOI: 10.1111/j.1469-0691.2012.03817.x
  • 14. Tassone L., Carvalho A.C., Calabresi A., Tortoli E., Apostoli A., Scomodon O., et al. Disseminated Mycobacterium genavense infection after immunosuppressive therapy shows underlying new composite heterozygous mutations of β1 subunit of IL-12 receptor gene. J Allergy Clin Immunol. 2013;131(2):607-610. DOI: 10.1016/j.jaci.2012.05.041
  • 15. Potjewijd J., de Paus R.A., van Wengen A., Damoiseaux J., Verbon A., van de Vosse E. Disseminated Mycobacterium genavense infection in a patient with a novel partial interleukin-12/23 receptor β1 deficiency. Clin Immunol. 2012;144(2):83-6. DOI: 10.1016/j.clim.2012.05.007
  • 16. Asakura T., Namkoong H., Sakagami T., Hasegawa N., Ohkusu K., Nakamura A. Disseminated Mycobacterium genavense infection in patient with adult-onset immunodeficiency. Emerg Infect Dis. 2017;23(7):1208-1210. DOI: 10.3201/eid2307.161677
  • 17. Ekermans P., de Gama R., Kock C., Hoosien E., Slavik T., Marshall T., Corcoran C., van Ingen J. An unusual case of abdominal mycobacterial infection: case report and literature review. South Afr J HIV Med. 2019;20(1):993. DOI: 10.4102/sajhivmed.v20i1.993
  • 18. Kyrilli A., Payen M.C., Antoine-Moussiaux T., Dewit S., Clumeck N. Meningitis and splenic infarction due to disseminated Mycobacterium genavense infection in an HIV patient. Case report and review of the literature. Acta Clin Belg. 2013;68(3):220-222. DOI: 10.2143/ACB.3204
  • 19. Pechère M., Opravil M., Wald A., Chave J.P., Bessesen M., Sievers A., et al. Clinical and epidemiologic features of infection with Mycobacterium genavense. Swiss HIV Cohort Study. Arch Intern Med. 1995;155(4):400-444. DOI: 10.1001/archinte.1995.00430040074009
  • 20. Thomsen V.O., Dragsted U.B., Bauer J., Fuursted K., Lundgren J. Disseminated infection with Mycobacterium genavense: a challenge to physicians and mycobacteriologists. J Clin Microbiol. 1999;37(12):3901-3905. DOI: 10.1128/JCM.37.12.3901-3905.1999
  • 21. Miyoshi H., Tamura G., Satoh T., Homma R., Omoto E., Nakano N., Wada R. Disseminated Mycobacterium genavense infection in a healthy boy. Hum Pathol. 2010;41(11):1646-1649. DOI: 10.1016/j.humpath.2010.02.017
  • 22. Arosio M., Ruggeri M., Buoro S., Locatelli A., Ortalli G., D'Antiga L., Farina C. Rapid diagnosis of Mycobacterium genavense disseminated infection by the Microseq 500: a case report in a two-year-old HIV-negative child. Ann Clin Lab Sci. 2016;46(5):549-551. PMID: 27650624.
  • 23. Manion M., Lynn N., Pei L., Hammoud D.A., Laidlaw E., Roby G., et al. To induce immune reconstitution inflammatory syndrome or suppress it: the spectrum of Mycobacterium genavense in the antiretroviral era. Clin Infect Dis. 2021;72(2):315-318. DOI: 10.1093/cid/ciaa753
  • 24. Brown-Elliott B.A., Nash K.A., Wallace R.J. Jr. Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria. Clin Microbiol Rev. 2012;25(3):545-582. DOI: 10.1128/CMR.05030-11
  • 25. Griffith D.E., Aksamit T., Brown-Elliott B.A., Catanzaro A., Daley C., Gordin F. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175:367-416. DOI: 10.1164/rccm.200604-571ST
  • 26. Girard V., Mailler S., Welker M., Arsac M., Cellière B., Cotte-Pattat P.J., et al. Identification of Mycobacterium spp. and Nocardia spp. from solid and liquid cultures by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). Diagn Microbiol Infect Dis. 2016;86(3):277-283. DOI: 10.1016/j.diagmicrobio.2016.07.027
  • 27. Lyamin A.V., Ismatullin D.D., Zhestkov A.V., Kondratenko O.V. The laboratory diagnostic in patients with mucoviscidosis: a review. Russian clinical laboratory diagnostics. 2018;63(5):315-320. Russian. DOI: 10.18821/0869-2084-2018-63-5-315-320
  • 28. Lange C., Böttger E.C., Cambau E., Griffith D.E., Guglielmetti L., van Ingen J., et al. Expert panel group for management recommendations in non-tuberculous mycobacterial pulmonary diseases. Consensus management recommendations for less common nontuberculous mycobacterial pulmonary diseases. Lancet Infect Dis. 2022;22(7):e178-e190. DOI: 10.1016/S1473-3099(21)00586-7
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