Probiotics as a means of strengthening commensal skin microbiota in the treatment of infected soft tissue wounds | CMAC

Probiotics as a means of strengthening commensal skin microbiota in the treatment of infected soft tissue wounds

Clinical Microbiology and Antimicrobial Chemotherapy. 2023; 25(3):239-246

​ Tulupov A.A., Beschastnov V.V., Tyumenkov Yu.O., Kovalishena O.V., Shirokova I.Yu., Belova I.V., Tochilina A.G., Solovieva I.V.
10.36488/cmac.2023.3.239-246
probiotics skin microbiota soft tissue wounds wound infection treatment
Section
Diseases and Pathogens
Type
Review
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2023; 25(3):239-246

Abstract

Probiotics can promote wound healing by stimulating the production of immune cells, activation of reparative regeneration processes as well as show antagonism against pathogenic microflora. The data presented in this review of the literature indicate that the local use of probiotics to enhance the microbiota of the skin in the fight against pathogens of wound infection is a scientifically sound direction demonstrating clinically significant positive results. The results of laboratory and experimental studies can form the basis for further development and development of methods for the clinical use of probiotics in the treatment of patients with infected wounds.

Alexander A. Tulupov

Privolzhsky Research Medical University, Nizhny Novgorod, Russia

Beschastnov V.V.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia

Tyumenkov Yu.O.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia

Kovalishena O.V.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia

Shirokova I.Yu.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia

Belova I.V.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology, Nizhny Novgorod, Russia

Tochilina A.G.

Privolzhsky Research Medical University, Nizhny Novgorod, Russia
Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology, Nizhny Novgorod, Russia

Solovieva I.V.

Academician I.N. Blokhina Nizhny Novgorod Scientific Research Institute of Epidemiology and Microbiology, Nizhny Novgorod, Russia

  • 1. Grice E.A., Segre J.A. The skin microbiome. Nat Rev Microbiol. 2011;9(4):244-253. DOI: 10.1038/nrmicro2537
  • 2. Dominguez-Bello M.G., Godoy-Vitorino F., Knight R., Blaser M.J. Role of the microbiome in human development. Gut. 2019;68(6):1108-1114. DOI: 10.1136/gutjnl-2018-317503
  • 3. Silbergeld E.K. The Microbiome. Toxicol Pathol. 2017; 45(1):190-194. DOI: 10.1177/0192623316672073
  • 4. Zeeuwen P.L., Boekhorst J., van den Bogaard E.H., de Koning H.D., van de Kerkhof P.M., Saulnier D.M., et al. Microbiome dynamics of human epidermis following skin barrier disruption. Genome Biol. 2012;13(11):R101. DOI: 10.1186/gb-2012-13-11-r101
  • 5. Pastar I., Nusbaum A.G., Gil J., Patel S.B., Chen J., Valdes J., et al. Interactions of methicillin resistant Staphylococcus aureus USA 300 and Pseudomonas aeruginosa in polymicrobial wound infection. PLoS One. 2013;8(2):e56846. DOI: 10.1371/journal.pone.0056846
  • 6. Di Domizio J., Belkhodja C., Chenuet P., Fries A., Murray T., Mondéjar P.M., et al. The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin. Nat Immunol. 2020;21(9):1034-1045. DOI: 10.1038/s41590-020-0721-6
  • 7. Gonzalez C.D., Ledo C., Cela E., Stella I., Xu C., Ojeda D.S., et al. The good side of inflammation: Staphylococcus aureus proteins SpA and Sbi contribute to proper abscess formation and wound healing during skin and soft tissue infections. Biochim Biophys Acta Mol Basis Dis. 2019;1865(10):2657-2670. DOI: 10.1016/j.bbadis.2019.07.004
  • 8. Götz F., Perconti S., Popella P., Werner R., Schlag M. Epidermin and gallidermin: Staphylococcal lantibiotics. Int J Med Microbiol. 2014;304(1):63-71. DOI: 10.1016/j.ijmm.2013.08.012
  • 9. Elias A.E., McBain A.J., O'Neill C.A. The role of the skin microbiota in the modulation of cutaneous inflammation – lessons from the gut. Exp Dermatol. 2021;30(10):15091516. DOI: 10.1111/exd.14420
  • 10. Wang G., Sweren E., Liu H., Wier E., Alphonse M.P., Chen R., et al. Bacteria induce skin regeneration via IL-1β signaling. Cell Host Microbe. 2021;29(5):777-791. DOI: 10.1016/j.chom.2021.03.003
  • 11. Roudsari M.R., Karimi R., Sohrabvandi S., Mortazavian A.M. Health effects of probiotics on the skin. Crit Rev Food Sci Nutr. 2015;55(9):1219-1240. DOI: 10.1080/10408398.2012.680078
  • 12. Guet-Revillet H., Dompmartin A., Join-Lambert O. Microbiote cutané: rôle physiologique et pathologique [Skin microbiome: role in human health and skin inflammatory diseases]. Rev Prat. 2020;70(6):653-656. PMID: 33058612.
  • 13. Byrd A.L., Belkaid Y., Segre J.A. The human skin microbiome. Nat Rev Microbiol. 2018;16(3):143-155. DOI: 10.1038/nrmicro.2017.157
  • 14. Tiffany C.R., Bäumler A.J. Dysbiosis: from fiction to function. Am J Physiol Gastrointest Liver Physiol. 2019;317(5):602608. DOI: 10.1152/ajpgi.00230.2019
  • 15. Lloyd-Price J., Abu-Ali G., Huttenhower C. The healthy human microbiome. Genome Med. 2016;8(1):51. DOI: 10.1186/s13073-016-0307-y
  • 16. Wexler H.M. Bacteroides: the good, the bad, and the nittygritty. Clin Microbiol Rev. 2007;20(4):593-621. DOI: 10.1128/CMR.00008-07
  • 17. Kumamoto C.A., Gresnigt M.S., Hube B. The gut, the bad and the harmless: Candida albicans as a commensal and opportunistic pathogen in the intestine. Curr Opin Microbiol. 2020;56:7-15. DOI: 10.1016/j.mib.2020.05.006
  • 18. Dréno B. The microbiome, a new target for ecobiology in dermatology. Eur J Dermatol. 2019;29(Suppl. 1):15-18. DOI: 10.1684/ejd.2019.3535
  • 19. Langdon A., Crook N., Dantas G. The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome Med. 2016;8(1):39. DOI: 10.1186/s13073-016-0294-z
  • 20. Schwartz D.J., Langdon A.E., Dantas G. Understanding the impact of antibiotic perturbation on the human microbiome. Genome Med. 2020;12(1):82. DOI: 10.1186/s13073020-00782-x
  • 21. Blaser M.J. Antibiotic use and its consequences for the normal microbiome. Science. 2016;352(6285):544-545. DOI: 10.1126/science.aad9358
  • 22. Sattler S. The role of the immune system beyond the fight against infection. Adv Exp Med Biol. 2017;1003:3-14. DOI: 10.1007/978-3-319-57613-8_1
  • 23. Tomic-Canic M., Burgess J.L., O'Neill K.E., Strbo N., Pastar I. Skin microbiota and its interplay with wound healing. Am J Clin Dermatol. 2020;21(1):36-43. DOI: 10.1007/s40257-020-00536-w
  • 24. Al-Ghazzewi F.H., Tester R.F. Impact of prebiotics and probiotics on skin health. Benef Microbes. 2014;5(2):99107. DOI: 10.3920/BM2013.0040
  • 25. Nelson M.H., Diven M.A., Huff L.W., Paulos C.M. Harnessing the microbiome to enhance cancer immunotherapy. J Immunol Res. 2015;2015:368736. DOI: 10.1155/2015/368736
  • 26. GOST R 56139-2014: Functional food products. Methods of determination and counting of probiotic microorganisms. M.: Standartinform; 2015. 36 p. Russian.
  • 27. World Gastroenterology Organization practice guideline: probiotics and prebiotics. J Clin Gastroenterol. 2017;51(9):755-767. DOI: 10.1097/MCG.0000000000000919
  • 28. Ganguly N.K., Bhattacharya S.K., Sesikeran B., Nair G.B., Ramakrishna B.S., Sachdev H.P.S., et al. ICMR-DBT guidelines for evaluation of probiotics in food. Indian J Med Res. 2011;134(1):22-25. PMID: 21808130.
  • 29. Shabrov A.V., Knyazkin I.V., Maryanovich A.T. Ilya Ilyich Mechnikov: encyclopedia of life and creativity. – SPb: DEAN; 2008. 1263 p. Russian.
  • 30. Mechnikov I.I. Milk microbes and the benefits they bring to health: (Yagurt). Translated from the French by L.Y. Gdansk. – SPb: knigoizd. 'A.F. Sukhova'; 1911. 32 p. Russian.
  • 31. Fijan S. Microorganisms with claimed probiotic properties: an overview of recent literature. Int J Environ Res Public Health. 2014;11(5):4745-4767. DOI: 10.3390/ijerph110504745
  • 32. Lukic J., Chen V., Strahinic I., Begovic J., Lev-Tov H., Davis S.C., et al. Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. Wound Repair Regen. 2017;25(6):912-922. DOI: 10.1111/wrr.12607
  • 33. Kern L., Abdeen S.K., Kolodziejczyk A.A., Elinav E. Commensal inter-bacterial interactions shaping the microbiota. Curr Opin Microbiol. 2021;63:158-171. DOI: 10.1016/j.mib.2021.07.011
  • 34. Joshi S., Kaur A., Sharma P., Harjai K., Capalash N. Lactonase-expressing Lactobacillus plantarum NC8 attenuates the virulence factors of multiple drug resistant Pseudomonas aeruginosa in co-culturing environment. World J Microbiol Biotechnol. 2014;30(8):2241-2249. DOI: 10.1007/s11274-014-1645-9
  • 35. Danilova Т.A., Adzhieva A.A., Danilina G.A., Polyakov N.B., Soloviev A.I., Zhukhovitsky V.G. Antimicrobial activity of supernatant of Lactobacillus plantarum against pathogenic microorganisms. Bull Exp Biol Med. 2019;167(6):751-754. DOI: 10.1007/s10517-01904615-9
  • 36. Jebur M.Sh. Therapeutic efficacy of Lactobacillus acidophilus against bacterial isolates from burn wounds. N Am J Med Sci. 2010;2(12):586-591. DOI: 10.4297/najms.2010.2586
  • 37. Coman M.M., Mazzotti L., Silvi S., Scalise A., Orpianesi C., Cresci A., Verdenelli M.C. Antimicrobial activity of SYNBIO® probiotic formulation in pathogens isolated from chronic ulcerative lesions: in vitro studies. J Appl Microbiol. 2020;128(2):584-597. DOI: 10.1111/jam.14482
  • 38. Al-Dulaimi M., Algburi A., Abdelhameed A., Mazanko M.S., Rudoy D.V., Ermakov A.M., et al. Antimicrobial and anti-biofilm activity of polymyxin E alone and in combination with probiotic strains of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 against clinical isolates of selected Acinetobacter spp.: a preliminary study. Pathogens. 2021;10(12):1574. DOI: 10.3390/pathogens10121574
  • 39. Abootaleb M., Mohammadi Bandari N., Arbab Soleimani N. Interference of Lactobacillus casei with Pseudomonas aeruginosa in the treatment of infected burns in Wistar rats. Iran J Basic Med Sci. 2021;24(2):143-149. DOI: 10.22038/IJBMS.2020.47447.10920
  • 40. Lenzmeier T.D., Mudaliar N.S., Stanbro J.A., Watters C., Ahmad A., Simons M.P., et al. Application of Lactobacillus gasseri 63 AM supernatant to Pseudomonas aeruginosa-infected wounds prevents sepsis in murine models of thermal injury and dorsal excision. J Med Microbiol. 2019;68(10):1560-1572. DOI: 10.1099/jmm.0.001066
  • 41. Valdéz J.C., Peral M.C., Rachid M., Santana M., Perdigón G. Interference of Lactobacillus plantarum with Pseudomonas aeruginosa in vitro and in infected burns: the potential use of probiotics in wound treatment. Clin Microbiol Infect. 2005;11(6):472-479. DOI: 10.1111/j.1469-0691.2005.01142.x
  • 42. Soleymanzadeh Moghadam S., Mohammad N., Ghooshchian M., FathiZadeh S., Khodaii Z., Faramarzi M., et al. Comparison of the effects of Lactobacillus plantarum versus imipenem on infected burn wound healing. Med J Islam Repub Iran. 2020;34:94. DOI: 10.34171/mjiri.34.94
  • 43. Satish L., Gallo P.H., Johnson S., Yates C.C., Kathju S. Local Probiotic Therapy with Lactobacillus plantarum mitigates scar formation in rabbits after burn injury and infection. Surg Infect (Larchmt). 2017;18(2):119-127. DOI: 10.1089/sur.2016.090
  • 44. Argenta A., Satish L., Gallo P., Liu F., Kathju S. Local Application of Probiotic bacteria prophylaxes against sepsis and death resulting from burn wound infection. PLoS One. 2016;11(10):e0165294. DOI: 10.1371/journal.pone.0165294
  • 45. Peral M.C., Martinez M.A., Valdez J.C. Bacteriotherapy with Lactobacillus plantarum in burns. Int Wound J. 2009;6(1):73-81. DOI: 10.1111/j.1742481X.2008.00577.x
  • 46. Peral M.C., Rachid M.M., Gobbato N.M., Huaman Martinez M.A., Valdez J.C. Interleukin-8 production by polymorphonuclear leukocytes from patients with chronic infected leg ulcers treated with Lactobacillus plantarum. Clin Microbiol Infect. 2010;16(3):281-286. DOI: 10.1111/j.1469-0691.2009.02793.x
  • 47. Stanbro J., Park J.M., Bond M., Stockelman M.G., Simons M.P., Watters C. Topical delivery of Lactobacillus culture supernatant increases survival and wound resolution in traumatic Acinetobacter baumannii infections. Probiotics Antimicrob Proteins. 2020;12(3):809-818. DOI: 10.1007/s12602-019-09603-z
  • 48. Venosi S., Ceccarelli G., de Angelis M., Laghi L., Bianchi L., Martinelli O., et al. Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: a novel tailored treatment strategy. J Transl Med. 2019;17(1):364. DOI: 10.1186/s12967-0192111-0
Views
0 Abstract
0 PDF
0 Crossref citations
Shared