Antimicrobial resistance of clinical Streptococcus pneumoniae isolates in Russia: the results of multicenter epidemiological study «PEHASus 2014–2017»

Clinical Microbiology and Antimicrobial Chemotherapy. 2019; 21(3):230-237

​ Ivanchik N.V., Chagaryan A.N., Sukhorukova M.V., Kozlov R.S., Dekhnich A.V., Krechikova O.I., Vinogradova A.G., Kuzmenkov A.Yu., Trushin I.V., Sivaya О.V., Muravyev A.A., Strebkova V.V., Kochneva N.А., Amineva P.G., Ishakova L.М., Dik N.G., Morozova О.А., Lazareva А.V., Chernyavskaya Yu.L., Kirillova G.Sh., Bekker G.G., Popova L.D., Elokhina Е.V., Zubareva N.А., Moskvitina E.N., Petrova Т.А., Zholobova А.F., Gudkova L.V., Khokhlyavin R.L., Burasova Е.B., Kholodok G.N., Panina О.А., Ershova М.G.
10.36488/cmac.2019.3.230-237
Streptococcus pneumoniae pneumococci antimicrobial resistance
Section
Antimicrobial Resistance
Type
Original Article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2019; 21(3):230-237

Objective.

To evaluate antimicrobial resistance patterns of clinical Streptococcus pneumoniae isolates from different regions of Russia during 2014–2017.

Materials and Methods.

We included in the study 519 clinical S. pneumoniae isolates from 18 Russian cities. Susceptibility testing was performed by reference broth microdilution method (ISO 20776-1:2006). Susceptibility testing results were interpreted according to EUCAST v.9.0 breakpoints.

Results.

Using EUCAST non-meningeal interpretation criteria, 65.1% of isolates tested were susceptible (S) to penicillin; in addition 28.9% were in the category “susceptible, increased exposure” (I). S and I to ampicillin were 74.8% and 11.0% of isolates; to ceftriaxone – 79.0% and 15.6%, respectively. S to ertapenem and ceftaroline were 93.6% and 98.1% of isolates. Almost all isolates (99.6%) were S to respiratory fluoroquinolones (levofloxacin and moxifloxacin) and chloramphenicol (98.3%). All isolates were S to linezolid and vancomycin. Different 14-15-member macrolides were active against 67.8%–72.8% of isolates, activity of clindamycin was significantly higher (85.9%). Susceptibility rates to tetracycline and trimethoprim/sulfamethoxazole were 66.1% and 59.0%, respectively.

Conclusions.

There was a trend to decrease in susceptibility of S. pneumoniae in Russia to conventional β-lactams, macrolides and lincosamides. The most in vitro active antimicrobials are respiratory fluoroquinolones, linezolid, vancomycin, ceftaroline and chloramphenicol.

Nataly V. Ivanchik

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Aida N. Chagaryan

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Marina V. Sukhorukova

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Roman S. Kozlov

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Andrey V. Dekhnich

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Olga I. Krechikova

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Alina G. Vinogradova

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Kuzmenkov Alexey Yuryevich

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Ivan V. Trushin

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Sivaya О.V.

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Alexander A. Muravyev

Institute of Antimicrobial Chemotherapy, Smolensk, Russia

Strebkova V.V.

Voronezh City Clinical Emergency Care Hospital #10, Voronezh, Russia

Kochneva N.А.

City Pediatric Clinical Hospital #11, Yekaterinburg, Russia

Amineva P.G.

Medical Center “Quality MED”, Yekaterinburg, Russia

Ishakova L.М.

Republican Clinical Hospital, Kazan, Russia

Dik N.G.

Krasnoturyinsk City Hospital #1, Krasnoturyinsk, Russia

Morozova О.А.

I.M. Sechenov First Moscow State Medical University, Moscow, Russia

Lazareva А.V.

National Medical Research Center for Children’s Health, Moscow, Russia

Chernyavskaya Yu.L.

Murmansk Regional Clinical Hospital named after P.A. Bayandin, Murmansk, Russia

Kirillova G.Sh.

Emergency Care Hospital, Naberezhnye Chelny, Russia

Bekker G.G.

Clinical Hospital at the Novosibirsk-Main Station, Novosibirsk, Russia

Popova L.D.

Regional Clinical Hospital, Omsk, Russia

Elokhina Е.V.

Omsk State Medical University, Omsk, Russia

Zubareva N.А.

Perm State Medical University named after E.A. Wagner, Perm, Russia

Ekaterina N. Moskvitina

Siberian Federal Scientific Clinical Center, Seversk, Russia

Petrova Т.А.

Clinical Hospital #1, Smolensk, Russia

Zholobova А.F.

Tolyatti City Clinical Hospital #5, Tolyatti, Russia

Gudkova L.V.

Tomsk Regional Clinical Hospital, Tomsk, Russia

Khokhlyavin R.L.

Tyumen State Medical University, Tyumen, Russia

Burasova Е.B.

Republican Clinical Hospital named after N.A. Semashko, Ulan-Ude, Russia

Kholodok G.N.

Institute of Motherhood and Children’s Health, Khabarovsk, Russia

Panina О.А.

Yuzhno-Sakhalinsk City Hospital named after F.S. Ankudinov, Yuzhno-Sakhalinsk, Russia

Ershova М.G.

Central City Clinical Hospital #1, Yaroslavl, Russia

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