Aetiology of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

Clinical Microbiology and Antimicrobial Chemotherapy. 2018; 20(3):232-238

Vasilieva V.A., Parovichnikova E.N., Drokov M.Yu., Kuzmina L.A., Klyasova G.A., Tikhomirov D.S., Tupoleva T.A., Koroleva O.M., Dubnyak D.S., Mikhaltsova E.D., Popova N.N., Konova Z.V., Savchenko V.G.

10.36488/cmac.2018.3.232-238

hemorrhagic cystitis allogeneic hematopoietic stem cell transplantation polyomavirus herpesvirus

Section

Personal Experience

Type

Journal article

Publication

Clinical Microbiology and Antimicrobial Chemotherapy. 2018; 20(3):232-238

Abstract Authors Literature PDF Statistics

Abstract

Incidence, severity, and risk factors for hemorrhagic cystitis (HC) were assessed in 267 patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). HC was diagnosed in 14.6% (39 patients) within 1-139 days after allo-HSCT (median duration – 39 days). Chemotherapy-related HC was diagnosed in 4 patients only. The majority (¹⁹⁄₃₅) of patients developed late HC of viral aetiology. Median time from a day of HC diagnosis to clinical symptoms resolution was 25 days (range: 6 to 133 days). Using a multivariate analysis, allo-HSCT from mismatched unrelated/haploidentical donor was found to be a risk factor of HC (р=0.01). The analysis also showed that 82.1% of patients with HC received cyclophosphamide as a part of conditioning regimen or +3/+4 days after allo-HSCT.

Vera A. Vasilieva

vasilievava4@mail.ru

National Medical Research Center of Hematology, Moscow, Russia

Parovichnikova E.N.

National Medical Research Center of Hematology, Moscow, Russia

Drokov M.Yu.

National Medical Research Center of Hematology, Moscow, Russia

Kuzmina L.A.

National Medical Research Center of Hematology, Moscow, Russia

Galina A. Klyasova

National Medical Research Center of Hematology, Moscow, Russia

Tikhomirov D.S.

National Medical Research Center of Hematology, Moscow, Russia

Tupoleva T.A.

National Medical Research Center of Hematology, Moscow, Russia

Koroleva O.M.

National Medical Research Center of Hematology, Moscow, Russia

Dubnyak D.S.

National Medical Research Center of Hematology, Moscow, Russia

Mikhaltsova E.D.

National Medical Research Center of Hematology, Moscow, Russia

Popova N.N.

National Medical Research Center of Hematology, Moscow, Russia

Konova Z.V.

National Medical Research Center of Hematology, Moscow, Russia

Savchenko V.G.

National Medical Research Center of Hematology, Moscow, Russia

1. Shepherd J.D., Pringle L.E., Barnett M.J., et al. Mesna versus hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation. J Clin Oncol. 1991;9(11):2016-2020.
2. Tomonari A., Takahashi S., Ooi J., et al. Hemorrhagic cystitis in adults after unrelated cord blood transplantation: a single-institution experience in Japan. Int J Hematol. 2006;84(3):268-271.
3. Silva L de P., Patah P.A., Saliba R.M., et al. Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type. Haematologica. 2010;95(7):1183-1190.
4. Arai Y., Maeda T., Sugiura H., et al. Risk factors for and prognosis of hemorrhagic cystitis after allogeneic stem cell transplantation: retrospective analysis in a single institution. Hematology. 2012;17(4):207-214.
5. Droller M.J., Saral R., Santos G. Prevention of cyclophosphamideinduced hemorrhagic cystitis. Urology. 1982;20(3):256-258.
6. Seber A., Shu X., Defor T., Sencer S., Ramsay N. Risk factors for severe hemorrhagic cystitis following BMT. Bone Marrow Transplant. 1999;23(1):35-40.
7. Lunde L.E., Dasaraju S., Cao Q., et al. Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: risk factors, graft source and survival. Bone Marrow Transplant. 2015;50(11):1432-1437.
8. Cheuk D.K.L., Lee T.L., Chiang A.K.S., et al. Risk factors and treatment of hemorrhagic cystitis in children who underwent hematopoietic stem cell transplantation. Transpl Int. 2007;20(1):73-81.
9. Gargiulo G., Orlando L., Alberani F., et al. Haemorrhagic cystitis in haematopoietic stem cell transplantation (HSCT): a prospective observational study of incidence and management in HSCT centres within the GITMO network (Gruppo Italiano Trapianto Midollo Osseo). Ecancermedicalscience. 2014;8:420.
10. Semenova E.V., Stancheva N.V., Alyanskiy A.L., et al. Allogeneic hematopoietic stem cells transplantation with reduced intensity conditioning regimen in children and adolescents with unfavorable forms of acute lymphoblastic leukemia. Onkogematologija. 2014;6(4):19-26. Russian.
11. Luznik L., Engstrom L.W., Iannone R., Fuchs E.J. Posttransplantation cyclophosphamide facilitates engraftment of major histocompatibility complex-identical allogeneic marrow in mice conditioned with low-dose total body irradiation. Biol Blood Marrow Transplant. 2002;8(3):131-138.
12. Drokov M.Yu., Parovichnikova E.N., Kuzmina L.A., et al. Allogenic bone marrow transplantation without pretransplantation conditioning and tolerance induction by cyclophosphamide and mesenchymal stromal cells. Gematologija i transfuziologija. 2014;59:42-46. Russian.
13. Philips F.S., Sternberg S.S., Cronin A.P., Vidal P.M. Cyclophosphamide and urinary bladder toxicity. Cancer Res. 1961;21:1577-1589.
14. Buckner C.D., Rudolph R.H., Fefer A., et al. High-dose cyclophosphamide therapy for malignant disease.Toxicity, tumor response, and the effects of stored autologous marrow. Cancer. 1972;29(2):357-365.
15. Brock N., Pohl J., Stekar J. Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention. 2. Comparative study on the uroprotective efficacy of thiols and other sulfur compounds. Eur J Cancer Clin Oncol. 1981;17(11):1155-1163.
16. Scheef W., Klein H.O., Brock N., et al. Controlled clinical studies with an antidote against the urotoxicity of oxazaphosphorines: preliminary results. Cancer Treat Rep. 1979;63(3):501-505.
17. Islam R., Isaacson B.J., Zickerman P.M., Ratanawong C., Tipping S.J. Hemorrhagic cystitis as an unexpected adverse reaction to temozolomide: case report. Am J Clin Oncol. 2002;25(5):513-514.
18. Manikandan R., Kumar S., Dorairajan L.N. Hemorrhagic cystitis: A challenge to the urologist. Indian J. Urol. 2010;26(2):159-166.
19. Apperley J.F., Rice S.J., Bishop J.A., et al. Late-onset hemorrhagic cystitis associated with urinary excretion of polyomaviruses after bone marrow transplantation. Transplantation. 1987;43(1):108-112.
20. Dropulic L.K., Jones R.J. Polyomavirus BK infection in blood and marrow transplant recipients. Bone Marrow Transplant. 2008;41(1):11-18.
21. Spach D.H., Bauwens J.E., Myerson D., Mustafa M.M., Bowden R.A. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation. Clin Infect Dis. 1993;16(1):142-144.
22. Gardner S.D., Field A.M., Coleman D.V., Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet. 1971;1(7712):1253-1257.
23. Hirsch H.H., Steiger J. Polyomavirus BK. Lancet Infect Dis. 2003;3(10):611-623.
24. Arthur R.R., Shah K.V., Baust S.J., Santos G.W., Saral R. Association of BK Viruria with Hemorrhagic Cystitis in Recipients of Bone Marrow Transplants. N Engl J Med. 1986;315(4):230-234.
25. Pappo O., Demetris A.J., Raikow R.B., Randhawa P.S. Human polyoma virus infection of renal allografts: histopathologic diagnosis, clinical significance, and literature review. Mod Pathol. 1996;9(2):105-109.
26. Coleman D.V., Gardner S.D., Mulholland C., et al. Human polyomavirus in pregnancy. A model for the study of defence mechanisms to virus reactivation. Clin Exp Immunol. 1983;53(2):289-296.
27. Kitamura T., Aso Y., Kuniyoshi N., Hara K., Yogo Y. High incidence of urinary JC virus excretion in nonimmunosuppressed older patients. J Infect Dis. 1990;161(6):1128-1133.
28. Leung A.Y.H., Yuen K-Y., Kwong Y-L. Polyoma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm. Bone Marrow Transplant. 2005;36(11):929-937.
29. Gorczynska E., Turkiewicz D., Rybka K., et al. Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2005;11(10):797-804.
30. Leung A.Y., Suen C.K., Lie A.K., et al. Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation. Blood. 2001;98(6):1971-1978.
31. Miller A.N., Glode A., Hogan K.R., et al. Efficacy and safety of ciprofloxacin for prophylaxis of polyomavirus BK virusassociated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients. Biol Blood Marrow Transplant. 2011;17(8):1176-1181.
32. Khalili K., Gordon J., White M.K. The Polyomavirus, JCV, and Its Involvement in Human Disease. In: Polyomaviruses and Human Diseases. New York, NY: Springer New York; 2006. pp. 274-287.
33. Ahsan N., Shah K.V. Polyomaviruses and Human Diseases. In: Polyomaviruses and Human Diseases. New York, NY: Springer New York; 2006. pp. 1-18.
34. Manna P., Grantham K., Reddy S., Nath R. JC virus reactivation in hemorrhagic cystitis complicating bone marrow transplantation patients. Biol. Blood Marrow Transplant. 2005;11(2):73.
35. Mufson M.A., Belshe R.B. A review of adenoviruses in the etiology of acute hemorrhagic cystitis. J Urol. 1976;115(2):191-194.
36. Miyamura K., Takeyama K., Kojima S., et al. Hemorrhagic cystitis associated with urinary excretion of adenovirus type 11 following allogeneic bone marrow transplantation. Bone Marrow Transplant. 1989;4(5):533-535.
37. Neofytos D., Ojha A., Mookerjee B., et al. Treatment of Adenovirus Disease in Stem Cell Transplant Recipients with Cidofovir. Biol Blood Marrow Transplant. 2007;13(1):74-81.
38. Akiyama H., Kurosu T., Sakashita C., et al. Adenovirus is a key pathogen in hemorrhagic cystitis associated with bone marrow transplantation. Clin Infect Dis. 2001;32(9):1325-1330.
39. Tomblyn M., Chiller T., Einsele H., et al. Guidelines for Preventing Infectious Complications among Hematopoietic Cell Transplantation Recipients: A Global Perspective. Biol Blood Marrow Transplant. 2009;15(10):1143-1238.
40. Troickaja V.V. Diagnosis and treatment of cytomegalovirus infection in patients with hemoblastosis. PhD thesis. Moscow, 2004. 154 p. Russian.
41. Tutuncuoglu S.O., Yanovich S., Ozdemirli M. CMV-induced hemorrhagic cystitis as a complication of peripheral blood stem cell transplantation: case report. Bone Marrow Transplant. 2005;36(3):265-266.
42. Ferrara J.L., Levy R., Chao N.J. Pathophysiologic mechanisms of acute graft-vs.-host disease. Biol Blood Marrow Transplant. 1999;5(6):347356.
43. Han T-T., Xu L-P., Liu D-H., et al. Cytomegalovirus is a potential risk factor for late-onset hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2014;89(1):55-61.
44. Miyamura K., Hamaguchi M., Taji H., et al. Successful ribavirin therapy for severe adenovirus hemorrhagic cystitis after allogeneic marrow transplant from close HLA donors rather than distant donors. Bone Marrow Transplant. 2000;25(5):545-548.
45. Held T.K., Biel S.S., Nitsche A., et al. Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir. Bone Marrow Transplant. 2000;26(3):347-350.
46. Garat J.M., Martínez E., Aragona F. Open instillation of formalin for cyclophosphamide-induced hemorrhagic cystitis in a child. Eur Urol. 1985;11(3):192-194.
47. Arrizabalaga M., Extramiana J., Parra J.L., et al. Treatment of massive haematuria with aluminous salts. Br J Urol. 1987;60(3):223-226.
48. Jerkins G.R., Noe H.N., Hill D.E. An unusual complication of silver nitrate treatment of hemorrhagic cystitis: case report. J Urol. 1986;136(2):456-458.
49. Laszlo D., Bosi A., Guidi S., et al. Prostaglandin E2 bladder instillation for the treatment of hemorrhagic cystitis after allogeneic bone marrow transplantation. Haematologica. 1995;80(5):421-425.
50. Hattori K., Yabe M., Matsumoto M., et al. Successful hyperbaric oxygen treatment of life-threatening hemorrhagic cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant. 2001;27(12):1315-1317.
51. Giné E., Rovira M., Real I., et al. Successful treatment of severe hemorrhagic cystitis after hemopoietic cell transplantation by selective embolization of the vesical arteries. Bone Marrow Transplant. 2003;31(10):923-925.
52. Cesaro S., Brugiolo A., Faraci M., et al. Incidence and treatment of hemorrhagic cystitis in children given hematopoietic stem cell transplantation: a survey from the Italian association of pediatric hematology oncology-bone marrow transplantation group. Bone Marrow Transplant. 2003;32(9) 925-931.
53. Ayas M., Siddiqui K., Al-Jefri A., et al. Factors affecting the outcome of related allogeneic hematopoietic cell transplantation in patients with Fanconi Anemia. Biol Blood Marrow Transplant. 2014;20(10):15991603.

Views

0 Abstract

0 PDF

0 Crossref citations

Shared

Cited by Crossref