Abstract
This study analyzed a prevalence of carbapenem-resistant Klebsiella pneumoniae strains obtained in the Privolzhsky Federal Medical Research Center units and their antibiotic resistance mechanisms. During the study year, the incidence of K. pneumoniae in different units was equal to that of Pseudomonas aeruginosa. The carbapenemresistant strains of K. pneumoniae were isolated in the average of 53.5% of patients in the burn units and 2.6% of patients in the purulent osteology unit. PCR testing showed that 100% of carbapenem-resistant strains had extended spectrum β-lactamase СТХ-М genes, 79.6% of isolates carried genes of ОХА-48 carbapenemase; and metallo-β-lactamase genes were not found. A whole genome sequencing detected blaSHV in all of the strains tested and a diversity of sequence types among K. pneumoniae strains, with ST395 being predominant. K. pneumoniae strains resistant to polymyxin E (colistin) were detected in all units, and their prevalence in adult patients with a burn trauma was 6.6%.
Privolzhsky Federal Medical Research Centre, Nizhny Novgorod, Russia
Nizhny Novgorod Research Institute of Epidemiology and Microbiology named after I.N. Blokhina, Nizhny Novgorod, Russia
Nizhny Novgorod Research Institute of Epidemiology and Microbiology named after I.N. Blokhina, Nizhny Novgorod, Russia
Nizhny Novgorod Research Institute of Epidemiology and Microbiology named after I.N. Blokhina, Nizhny Novgorod, Russia
Central Research Institute of Epidemiology, Moscow, Russia
Privolzhsky Federal Medical Research Centre, Nizhny Novgorod, Russia
Privolzhsky Federal Medical Research Centre, Nizhny Novgorod, Russia
Privolzhsky Federal Medical Research Centre, Nizhny Novgorod, Russia
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