Surveillance of antimicrobials use in neonatal hospitals with alternative DDD methods | CMAC

Surveillance of antimicrobials use in neonatal hospitals with alternative DDD methods

Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(1):31-36

​ Lyubasovskaya L.A., Maikova G.B., Melkumyan A.R., Zubkov V.V., Ionov O.V., Kirtbaya A.R., Podurovskaya Yu.L., Burov A.A., Priputnevich T.V., Zyryanov S.K.
antibiotic use neonatal intensive care unit antimicrobial resistance pharmacological monitoring Antimicrobial Stewardship Program infection
Section
Antimicrobials
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2017; 19(1):31-36

Abstract

One of the most common problems in neonatal hospitals is the choice of metrics of drugs usage in neonatology, especially use of antibiotics. This study represents our experience in quantifying antibiotic use in a Level-III neonatal intensive care units (NICUs) implementing two methods: days of therapy (DOT) and length of therapy (LOT). Our objective was to quantify antibiotic use by most common metrics of Antimicrobial Stewardship Programs in NICUs of Europe, USA and Canada in order to standardize antibiotic use measures in Russian neonatal hospitals. The study included analysis of medical records for infants who were treated in two NICUs in 2014. Our study demonstrated the suitability of the method for pharmacological monitoring and Antimicrobial Stewardship Program in neonatal hospitals despite some limitations. It permits to quantify and compare all antibiotic use and antibiotic prescription rate between departments and different neonatal hospitals.

Lyudmila A. Lyubasovskaya

V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia

Maikova G.B.

V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia

Melkumyan A.R.

V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia

Zubkov V.V.

V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia

Ionov O.V.

V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia

Kirtbaya A.R.

V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia

Podurovskaya Yu.L.

V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia

Burov A.A.

V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia

Priputnevich T.V.

V.I. Kulakov Research Center of Obstetrics, Gynecology and Perinatology, Moscow, Russia

Sergey K. Zyryanov

RUDN University, Moscow, Russia

  • 1. WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment, 2013. Oslo: WHO Collaborating Centre for Drug Statistics Methodology; 2012.
  • 2. Morris AM. Antimicrobial Stewardship Programs: Appropriate Measures and Metrics to Study their Impact. Curr Treat Options Infect Dis 2014;6(2): 101-12.
  • 3. Madaras-Kelly K. Optimizing antibiotic use in hospitals: the role of population-based antibiotic surveillance in limiting antibiotic resistance. Insights from the society of infectious diseases pharmacists. Pharmacother 2003;23(12):1627-33.
  • 4. Габбасова ЛА, Шаповалова ЮС. Роль ATC/DDD – методологии в оптимизации практики применения антибактериальных препаратов в условиях многопрофильного лечебно-профилактического учреждения. Качественная клиническая практика 2008;2:39-46.
  • 5. Божкова СА, Разоренов ВЛ, Борисов АМ. Применение DDD-анализа для коррекции и контроля потребления антибиотиков при лечении парапротезной инфекции. Экология человека 2012;4:52-7.
  • 6. Зубков ВВ, Рюмина ИИ, Евтеева РВ, Припутневич ТВ, Митрохин СД, Тютюнник ИЛ. Обзор потребления антимикробных препаратов у новорожденных с инфекционно-воспалительными заболеваниями. Российский вестник перинатологии и педиатрии 2013;2:12-6.
  • 7. Cantey JB, Wozniak PS, Sánchez PJ. Prospective surveillance of antibiotic use in the neonatal intensive care unit: results from the SCOUT study. Pediatr Infect Dis J 2015;34(3):267-72.
  • 8. Hersh AL, De Lurgio SA, Thurm C, et al. Antimicrobial stewardship programs in freestanding children’s hospitals. Pediatrics 2015;135:33-9.
  • 9. Steinberg M, Dresser LD, Daneman N, et al. National survey of critical care physicians’ knowledge, attitudes, and perceptions of antimicrobial stewardship programs. J Intensive Care Med 2016;31:61-5.
  • 10. Simonsen KA, Anderson-Berry AL, Delair SF, Davies HD. Early-onset neonatal sepsis. Clin Microbiol 2014;27:21-47.
  • 11. Cohen-Wolkowiez M, Moran C, Benjamin DK, Cotten CM, Clark RH, Benjamin DK, Smith PB. Early and late onset sepsis in late preterm infants. Pediatr Infect Dis J 2009;28:1052-6.
  • 12. Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin N Am 2013;60:367-89.
  • 13. Любасовская ЛА, Припутневич ТВ, Анкирская АС, Дегтярев ДН, Антонов АГ, Ионов ОВ и соавт. Особенности микробной колонизации новорожденных в отделении реанимации и интенсивной терапии. Российский вестник перинатологии и педиатрии 2013;3:87-91.
  • 14. Nowicki PT. Ischemia and necrotizing enterocolitis: where, when and how. Semin Pediatr Surg 2005;14:152-8.
  • 15. Lin PW, Stoll BJ. Necrotizing enterocolitis. Lancet 2006;368:1271-83.
  • 16. Morowitz MJ, Poroyko V, Caplan M, Alverdy J, Liu DC. Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis. Pediatrics 2010;125:777-85.
  • 17. Bizzarro MJ, Ehrenkranz RA, Gallagher PG. Concurrent bloodstream infections in infants with necrotizing enterocolitis. J Pediatr 2014;164:61-6.
  • 18. Krediet TG, van Lelyveld N, Vijlbrief DC, Brouwers HA, Kramer WL, Fleer A, Gerards LJ. Microbiological factors associated with neonatal necrotizing enterocolitis: protective effect of early antibiotic treatment». Acta Paediatrica 2003;92:1180-2.
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