Abstract
colonization of gastric mucosa with Helicobacter pylori in patients with precancerous conditions (adenomatous polyp, hyperplastic polyp, focal hypertrophy, erosions) and gastric cancer (adenocarcinoma, signet ring cell carcinoma, carcinoid). The incidence of H. pylori infection was 75.5±3.1% in the overall patient population and 72.2±7.5% among patients with gastric cancer. The patients with gastric cancer had a high grade of colonization (104–105 CFU/biopsy). Most patients with precancerous conditions had intermediate and high grades of antral mucosa colonization with H. pylori. Antimicrobial susceptibility of H. pylori was determined by disk diffusion method. Susceptibility rates of H. pylori to clarithromycin, amoxicillin, metronidazole, tetracycline, and ciprofloxacin were 85%, 79%, 32%, 65%, and 90%, respectively.
Kazan State Medical Academy, Kazan, Russia
Kazan State Medical Academy, Kazan, Russia
Kazan State Medical University, Kazan, Russia
Kazan State Medical Academy, Kazan, Russia
Kazan State Medical Academy, Kazan, Russia
Republican Clinical Oncology Dispensary, Kazan, Russia
-
1.
C Working Group: Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994. C Monogr Eval Carcinog Risks Hum 1994; 61:1-241.
-
2.
Wu C.Y., Kuo K.N., Wu M.S., et al. Early Helicobacter pylori eradication decreases risk of gastric cancer in patients with peptic ulcer disease. Gastroenterology 2009; 137:1641-8.
-
3.
Ma J.L., Zhang L., Brown L.M., et al. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst 2012; 104:488-92.
-
4.
Correa P., Fontham E. T., Bravo J. C., et al. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy. J Natl Cancer Inst 2000; 92:1881-8.
-
5.
Fuccio L., Zagari R.M., Eusebi L.H., et al. Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer? Ann Intern Med 2009; 151:121-8.
-
6.
Cavaleiro-Pinto M., Peleteiro B., Lunet N., Barros H. Helicobacter pylori infection and gastric cardia cancer: systematic review and meta-analysis. Cancer Causes Control 2011; 22:375-8
-
7.
Eidt S., Stolte M. Prevalence of intestinal metaplasia in Helicobacter pylori gastritis. Scand J Gastroenterol 1991; 29: 607-10.
-
8.
Kokkola A., Sipponen P., Pautelin. H., et al. The effect of Helicobacter pylory eradication on the natural course of atrophic gastritis with dysplasia. Aliment Pharmacol Ther 2002; 16:515-20.
-
9.
Sakaki N., Kozswa H., Egaea N., et al. Ten-year prospective follow-up study on the relationship between Helicobacter pylori infection and progression of atrophic gastritis, particularly assessed by endoscopic findings. Aliment Pharmacol Ther 2002; 16:198-203.
-
10.
Fichman S., Niv Y. Histological changes in the gastric mucosa after Helicobacter pylori eradication. Eur J Gastroenterol Hepatol 2004; 16:1183-88.
-
11.
Hojo M., Miwa H., Ohkusa T., et. al. Alteration of histological gastritis after cure of Helicobacter pylori infection. Aliment Pharmacol Ther 2002; 16:1923-32.
-
12.
Старостин Б.Д., Петрутик А.В. Экспресс-метод диагностики инфицированности Campylobacter pylori желудка и двенадцатиперстной кишки. Клиническая медицина 1989; 67:50-2.
-
13.
McNulty C., Owen R., Tompkins D., et al. Helicobacter pylori susceptibility testing by disc diffusion. J Antimicrob Chemother 2002; 49:601-9.
-
14.
Correa P. Helicobacter pylori and gastric carcinogenesis. Am J Surg Pathol 1995; 19 (Suppl 1): S37-S43.
-
15.
Take S., Mizuno M., Ishiki K., et al. The long-term risk of gastric cancer after the successful eradication of Helicobacter pylori. J Gastroenterol 2011; 46:318-24.
-
16.
Fukase K., Kato M., Kikuchi S., et al. Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial. Lancet 2008; 372:392-7.
-
17.
Maehata Y., Nakamura S., Fujisawa K., et al. Longterm effect of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic resection of early gastric cancer. Gastrointest Endosc 2012; 75:39-46.
-
18.
Kato M., Nishida T., Yamamoto K., et al. Scheduled endoscopic surveillance controls secondary cancer after curative endoscopic resection for early gastric cancer: a multicentre retrospective cohort study by Osaka University ESD study group. Gut 2013; 62:1425-32.