A Clinical Case of Acute Herpesvirus and Pneumocystis Co-infection in a Patient with Progressive Pulmonary Tuberculosis | CMAC

A Clinical Case of Acute Herpesvirus and Pneumocystis Co-infection in a Patient with Progressive Pulmonary Tuberculosis

Clinical Microbiology and Antimicrobial Chemotherapy. 2016; 18(3):231-238

​ Shibanov A.M., Osadchaya O.A., Rybalkina T.N., Karazhas N.V., Kornienko M.N., Kalugina M.Yu., Zyuzya Yu.R., Stakhanov V.A.
tuberculosis pneumonia multidrugresistant tuberculosis herpesvirus pneumocystis
Section
Personal Experience
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2016; 18(3):231-238

Abstract

This article describes a clinical case of fatal polymicrobial pneumonia in a patient with progressive pulmonary tuberculosis. The clinical case represents a co-infection with tuberculosis, viral and pneumocystis infection in a HIV-uninfected patient with the long-term immune deficiency state. The pathogenesis, potential interactions and effects of concurrent infections on immunity are also considered.

Alexey M. Shibanov

Tuberculosis Clinical Hospital #3 named after G.A. Zakhar’in, Moscow, Russia
Pirogov Russian National Research Medical University, Moscow, Russia

Osadchaya O.A.

Tuberculosis Clinical Hospital #3 named after G.A. Zakhar’in, Moscow, Russia

Tayana N. Rybalkina

Federal Research Center of Epidemiology and Microbiology named after N.F. Gamaleya, Moscow, Russia

Karazhas N.V.

Federal Research Center of Epidemiology and Microbiology named after N.F. Gamaleya, Moscow, Russia

Kornienko M.N.

Federal Research Center of Epidemiology and Microbiology named after N.F. Gamaleya, Moscow, Russia

Kalugina M.Yu.

Federal Research Center of Epidemiology and Microbiology named after N.F. Gamaleya, Moscow, Russia

Zyuzya Yu.R.

Moscow Scientific Anti-Tuberculosis Center, Moscow, Russia

Stakhanov V.A.

Pirogov Russian National Research Medical University, Moscow, Russia

  • 1. Berg Van de P.J,, Heutinck K.M, Raabe R., et al. Human cytomegalovirus induces systemic immune activation characterized by atype 1 cytokine signature. J Infect Dis 2010; 202:690-9.
  • 2. Biegeleisen K., Rush M.G. Association of herpes simplex virus type 1 DNA with host chromosomal DNA during productive infection. Virology1976:69:246-57.
  • 3. Britt W. Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease. Curr Top Microbiol Immunol 2008; 325:417-70.
  • 4. Decrion A.Z., Dichamp I., Varin A. et al. HIV and inflammation.Curr HIV Res 2005; 3:243-59.
  • 5. Docke W.D., Prosch S., Fietze E., et al. Cytomegalovirus reactivation and tumour necrosis factor. Lancet1994; 343:268-9.
  • 6. Docke W.D., Kiessling C., Worm M., et al. Subclinical activation of latent cytomegalovirus (CMV) infection and anti-CMV immune response in patients with atopic dermatitis.Br J Dermatol 2003; 148:954-63.
  • 7. Koskinen P.K., Kallio E.A., Tikkanen J.M., et al. Cytomegalovirus infection and cardiac allograft vasculopathy. Transpl Infect Dis 1999; 1:115-26.
  • 8. Kline J.N., Hunninghake G.M., He B., et al. Synergistic activation of the human cytomegalovirus major immediate early promoter by prostaglandin E2 and cytokines.Exp Lung Res 1998; 24:3-14.
  • 9. Prosch S., Wendt C.E., Reinke P., et al. A novel link between stress and human cytomegalovirus (HCMV) infection: sympathetic hyperactivity stimulates HCMV activation. Virology 2000; 272:357-65.
  • 10. Kutok J.L., Wang F. Spectrum of Epstein-Barr virusassociated diseases. Annu Rev Pathol 2006; 1:375-404.
  • 11. Limper A.H., Offord K.P., Smith T.F., et al. Pneumocystiscarinii pneumonia. Differences in lung parasite number and inflammation in patients with and without AIDS. Am Rev Respir Dis 1989; 140(5):1204-9.
  • 12. Каражас Н.В. Пневмоцистоз. Современное состояние проблемы. Альманах клинической медицины 2010; 23:49-55.
Views
0 Abstract
0 PDF
0 Crossref citations
Shared