Use of Antimicrobial Agents in Elderly Patients | CMAC

Use of Antimicrobial Agents in Elderly Patients

Clinical Microbiology and Antimicrobial Chemotherapy. 2015; 17(4):267-271

​ Ortenberg E.A.
elderly patients antimicrobial agents efficacy safety drug interactions
Section
Antimicrobials
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2015; 17(4):267-271

Abstract

This article describes the factors contributing reduced efficacy of antimicrobial agents in elderly patients, as well as the factors and mechanisms compromising safety of this drug class. Specific aspects of the administration of different antimicrobial agent classes in the most common infections in elderly patients, such as respiratory tract infections, urinary tract infections and skin and skin structure infections, are considered in detail. Data on drug interactions between antimicrobial agents and other medication classes commonly used for the treatment of underlying medical conditions in the elderly are also presented.

Eduard A. Ortenberg

Tyumen State Medical University, Tyumen, Russia

  • 1. Cohen J.E. Human population: the next half century. Science 2003; 302:1172-5.
  • 2. Albert S., Schafer V., Brade V. Epidemiology and therapy of bacterial infections in geriatrics. Z Gerontol Geriatr 2000; 33:357-66.
  • 3. Gruver A., Hadson L., Semprowski G. Immunosenescence of ageing. J Pathol 2007; 211:144-56.
  • 4. Hakim F.T., Gress R.E. Immunosenescence: deficits in adaptive immunity in the elderly. Tissue Antigens 2007; 70:179-89.
  • 5. Krokan H.E., Kavli B., Slupphaug G. Novel aspects of macromolecular repair and relationship to human disease. J Mol Med 2004; 82:280-97.
  • 6. Нозокомиальная пневмония у взрослых: практические рекомендации по диагностике, лечению и профилактике. Клин микробиол антимикроб химиотер 2005; 7(1):4-31.
  • 7. Garibaldi R.A. Residential care and the elderly: the burden of infection. J Hosp Infect 1999; 43(Suppl):9-18
  • 8. Gavazzi G., Krause K.H. Ageing and infection. Lancet Infect Dis 2002; 2(11):659-66.
  • 9. Nicolle L.E., Strausbaugh L.J., Garibaldi R.A. Infections and antibiotic resistance in nursing homes. Clin Microbiol Rev 1996; 9:1-17.
  • 10. Saner H. Cardiovascular system and aging. Ther Umsch 2005; 62:827-35.
  • 11. Faulkner C.M., Cox H.L., Williamson J.C. Unique aspects of antimicrobial use in older adults. Clin Infect Dis 2005; 40:997-1004.
  • 12. Sherlock S., Bearn A.G., Billing B.H., Paterson J.C. Splanchnic blood flow in man by the bromsulfalein method: the relation of peripheral plasma bromsulfalein level to the calculated flow. J Lab Clin Med 1950; 35:923-32.
  • 13. Bonomo R.A. Resistant pathogens in respiratory tract infections in older people. J Am Geriatr Soc 2002; 50(7 Suppl):236-41.
  • 14. Marrie T.J. Community-acquired pneumonia requiring hospitalization. Is it different in the elderly? J Am Geriatr Soc 1985; 33:671-80.
  • 15. Gregoratos G. Infective endocarditis in the elderly: diagnosis and management. Am J Geriatr Cardiol 2003; 12:183-9.
  • 16. Inelmen E.M., Sergi G., Enzi G. When are indwelling urinary catheters appropriate in elderly patients? Geriatrics 2007; 62:18-22.
  • 17. Синопальников А.И., Андреева И.В., Стецюк О.У. Пневмонии в домах престарелых: современный взгляд на проблему. Клин микробиол антимикроб химиотер 2007; 9(1):4-19.
  • 18. Marques L.P., Flores J.T., de Barros O., et al. Epidemiological and clinical aspects of urinary tract infection in community-dwelling elderly women. Braz J Infect Dis 2012; 16(5):436-41.
  • 19. Siegel J.D., Rhinehart E., Jackson M., Chiarello L. Management of Multidrug-Resistant Organisms in Healthcare Settings, 2006. Atlanta, GA: Centers for Disease Control and Prevention; 2006. [Accessed May 25, 2013]. Available from: http://www.cdc.gov/hicpac/pdf/guidelines/MDROGuideline2006.pdf.
  • 20. Ben-Ami R., Schwaber M.J., Navon-Venezia S., et al. Influx of extended-spectrum beta-lactamase-producing enterobacteriaceae into the hospital. Clin Infect Dis 2006; 42:925-34.
  • 21. Pop-Vicas A., Tacconelli E., Gravenstein S., Lu B., D’Agata E.M. Influx of multidrug-resistant, gram-negative bacteria in the hospital setting and the role of elderly patients with bacterial bloodstream infection. Infect Control Hosp Epidemiol 2009; 30:325-31.
  • 22. Sersté T., Bourgeois N. Ageing and the liver. Acta Gastroenterol Belg 2006; 69:296-8.
  • 23. Rowe J.W., Andres R., Tobin J.D., et al. The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. J Gerontol 1976; 31:155-63.
  • 24. Davies D.F., Shock N.W. Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest 1950; 29:496-507.
  • 25. Stahlmann R., Lode H.M. Risks associated with the therapeutic use of fluoroquinolones. Expert Opin Drug Saf 2013; 12(4):497-505.
  • 26. Ho J., Juurlink D. Considerations when prescribing trimethoprim-sulfamethoxazole CMAJ 2011; 183:1851-8.
  • 27. Peetermans W., Verbist L. Coagulation disorders caused by cephalosporins containing methylthiotetrazole side chains. Acta Clin Belg 1990; 45(5):327-33.
  • 28. Cusack B.J. Pharmacokinetics in older persons. Am J Geriatr Pharmacother 2004; 2:274-302.
  • 29. Hébuterne X. Gut changes attributed to ageing: effects on intestinal microflora. Curr Opin Clin Nutr Metab Care 2003; 6:49-54.
  • 30. Di Bella S., Capone A., Musso M., et al. Clostridium difficile infection in the elderly. Infez Med 2013; 21:93-102.
  • 31. Grill M.F., Maganti R. Cephalosporin-induced neurotoxicity: clinical manifestsations, potential pathogenic mechanisms, and the role of electroencephalographic monitoring. Ann Pharmacother 2008; 42:1843-50.
  • 32. Chow K.M., Hui A.C., Szeto C.C. Neurotoxicity induced by beta-lactam antibiotics: from bench to bedside. Eur J Clin Microbiol Infect Dis 2005; 24:649-53.
  • 33. Sugimoto M., Uchida I., Mashimo T., et al. Evidence for the involvement of GABA(A) receptor blockage in convulsions induced by cephalosporins. Neuropharmacology 2003; 45:304-14.
  • 34. Greenblatt D.J., Sellers E.M., Shader R.I. Drug therapy: drug disposition in old age. N Engl J Med 1982; 306:1081-8.
  • 35. Shi S., Klotz U. Age-related changes in pharmacokinetics. Curr Drug Metab 2011; 12:601-10.
  • 36. Cotter M. , Donlon S., Roche F., Byrne H., Fitzpatrick F. Healthcare-associated infection in Irish long-term care facilities: results from the First National Prevalence Study. J Hosp Infect 2012; 80:212-6.
  • 37. Curns A.T., Holman R.C., Sejvar J.J., et al. Infectious disease hospitalizations among older adults in the United States from 1990 through 2002. Arch Intern Med 2005; 165:2514-20.
  • 38. Liang S.Y., Mackowiak P.A. Infections in the elderly. Clin Geriatr Med 2007; 23:441-56.
  • 39. Werner H., Kuntsche J. Infection in the elderly-what is different? Z Gerontol Geriatr 2000; 33:350-6.
  • 40. Ferrara A., Fietta A. New developments in antibacterial choice for lower respiratory tract infections in elderly patients. Drugs Aging 2004; 21:167-86.
  • 41. Roede B.M., Bresser P., El Moussaoui R., et al. Three vs. 10 days of amoxycillin-clavulanic acid for type 1 acute exacerbations of chronic obstructive pulmonary disease: a randomised, double-blind study. Clin Microbiol Infect 2007; 13:284-90.
  • 42. Andriole V.T., Haverstock D.C., Choudhri S.H. Retrospective analysis of the safety profile of oral moxifloxacin in elderly patients enrolled in clinical trials. Drug Saf 2005; 28:443-52.
  • 43. Neralla S., Meyer K. Drug treatment of pneumococcal pneumonia in the elderly Drugs Aging 2004; 21:851-64.
  • 44. Van den Brande P., Van Stennbergen W., Vervoort G., et al. Aging and hepatotoxicity of isoniazid and rifampin in pulmonary tuberculosis. Am J Respir Crit Care Med 1995; 152:1705-8.
  • 45. Smith N.M. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP) MMWR Recomm Rep 2006; 55(RR-10):1-42.
  • 46. Das R., Perrelli E., Towle V., et al. Antimicrobial susceptibility of bacteria isolated from urine samples obtained from nursing home residents. Infect Control Hosp Epidemiol 2009; 30(11):1116-9.
  • 47. Takahashi P., Trang N., Chutka D., Evans J. Antibiotic prescribing and outcomes following treatment of symptomatic urinary tract infections in older women. J Am Med Dir Assoc 2004; 5(2 Suppl): S11-5.
  • 48. Finn J.C., Flicker L., Mackenzie E., et al. Interface between residential aged care facilities and a teaching hospital emergency department in Western Australia. Med J Aust 2006; 184:432-5.
  • 49. Boockvar K.S., Gruber-Baldini A.L., Burton L., Zimmerman S., May C., Magaziner J. Outcomes of infection in nursing home residents with and without early hospital transfer. J Am Geriatr Soc 2005; 53(4):590-6.
  • 50. Washio M., Kiyohara C., Hamada T,. et al. The case fatality rate of methicillin-resistant Staphylococcus aureus (MRSA) infection among the elderly in a geriatric hospital and their risk factors. The Tohoku Journal of Experimental Medicine 1997; 183:75-82.
  • 51. Lim C., Kong D., Stuart R. Reducing inappropriate antibiotic prescribing in the residential care setting: current perspectives Clin Interv Aging 2014; 9:165-77.
  • 52. McClean P., Hughes C., Tunney M., Goossens H., Jans B. European Surveillance of Antimicrobial Consumption (ESAC) Nursing Home Project Group Antimicrobial prescribing in European nursing homes. J Antimicrob Chemother 2011; 66:1609-16.
  • 53. Howard P.A. Azithromycin-induced proarrhythmia and cardiovascular death. Ann Pharmacother 2013; 47:1547-51.
  • 54. Ray W.A., Murray K.T., Meredith S., et al. Oral erythromycin and the risk of sudden death from cardiac causes. N Engl J Med 2004; 351:1089-96.
  • 55. Shakeri-Nejad K., Stahlmann R. Drug interactions during therapy with three major groups of antimicrobial agents. Expert Opin Pharmacother 2006; 7(6):639-51.
  • 56. Mills K., Graham A.C., Winslow B.T., Springer K.L. Treatment of nursing home-acquired pneumonia. Am Fam Physician 2009; 79(11):976-82.
  • 57. Dumyati G., Falsey A.R. Antivirals for influenza: what is their role in the older patient? Drugs Aging 2002; 19:777-86.
  • 58. Guay D.R.P. Amantadine and rimantadine prophylaxis of influenza A in nursing homes: a tolerability perspective. Drugs Aging 1994; 5:8-19.
  • 59. Obez C., Barisic A.M., Chatelier W., et al. The computerassisted management programs for antibiotic therapies in connection with an application in geriatrics. Pathol Biol 2004; 52:589-96.
  • 60. Naughton B.J., Mylotte J.M. Treatment guideline for nursing home-acquired pneumonia based on community practice. J Am Geriatr Soc 2000; 48(1):82-8.
  • 61. Sicras M.A., Pelaez L.J. Improving adequacy for drug use and effects in geriatric centers using an intervention program. Farm Hosp 2005; 29(5):303-11.
Views
0 Abstract
0 PDF
0 Crossref citations
Shared