Abstract
The changes in carbapenem consumption during 6 consecutive years have been studied in retrospective trial. 88% of carbapenems have been administered in the ICU’s and hematology department. The 3-fold increase of the total consumption during observational period has been registered, mainly – due to meropenem generics. The association of generic consumption elevation with the more frequent detection of A. baumannii carbapenemresistant strains and the tendency for increased attributable mortality in the burn centre ICU have been observed.
-
1.
Зырянов С.К., Белоусов Ю.Б. Проблема качества генериков и оценка их соответствия оригинальным препаратам. Клин микробиол антимикроб химиотер 2010; 12(4):314-20.
-
2.
Diaz J.A, Silva E., Arias M. J., et al. Comparative in vitro study of the antimicrobial activities of different commercial antibiotic products of vancomycin. BMC Clin Pharmacol 2011; 11:9.
-
3.
Jensen U.S., Skjоt-Rasmussen L., Olsen S.S., et al. Consequences of increased antibacterial consumption and change in pattern of antibacterial use in Danish hospitals. J Antimicrob Chemother 2009; 63(4):812-5.
-
4.
Jensen U.S., Muller A., Brandt C.T., et al. Effect of generics on price and consumption of ciprofloxacin in primary healthcare: the relationship to increasing resistance. J Antimicrob Chemother 2010; 65(6):1286-915.
-
5.
Available at: www.whocc.no/atcddd.
-
6.
Решедько Г.К., Рябкова У.Л., Фаращук А.Н., Страчунский Л.С. Неферментирующие грамотрицательные возбудители нозокомиальных инфекций в ОРИТ России: проблемы антибиотикорезистентности. Клин микробиол антимикроб химиотер 2006; 8(3):243-59.
-
7.
Zuluaga A.F., Agudelo M., Rodriguez C.A., et al. Application of microbiological assay to determine pharmaceutical equivalence of generic intravenous antibiotics. BMC Clin Pharmacol 2009; 9:1.
-
8.
Vesga O., Agudelo M., Salazar B.E., et al. Generic vancomycin enriches resistant subpopulations of Staphylococcus aureus after exposure in a neutropenic mouse thigh infection model. Antimicrob Agents Chemother 2010; 54(8):3271-9.
-
9.
Rodriguez C. A., Agudelo M., Zuluaga A.F., et al. Generic vancomycin enriches resistant subpopulations of Staphylococcus aureus after exposure in a neutropenic mouse thigh infection model. Antimicrob Agents Chemother 2012; 56(1):243-7.
-
10.
Zuluaga A.F., Agudelo M., Cardeño J., et al. Determination of therapeutic equivalence of generic products of gentamicin in the neutropenic mouse thigh infection model. J Vet Pharmacol Ther 2004; 27(6):397-414.
-
11.
Del Tacca M., Pasqualetti G., Di Paolo A., et. al. Lack of pharmacokinetic bioecvivalence between generic and branded amoxicillin formulations. A post- marketing clinical study on healthy volunteers. Br J Clin Pharmacol 2009; 68(1):34-42.
-
12.
Lambert P.A., Conway B.R. Parmaceutical quality of ceftriaxone generic drug products compared with Rocephin. J Chemother 2003; 15(4):357-68.
-
13.
Никулин А. А., Цюман Ю. П., Мартинович А. А., Эйдельштейн М. В, Козлов Р.С. Об адекватности замены генериками внутривенных форм оригинальных препаратов: нужны ли сравнительные исследования? Клин микробиол антимикроб химиотер 2010; 12(1):31-40.
-
14.
Кузнецова М. В., Карпунина Т.И., Егорова Д. О., Плотникова Е.Г., Демаков В.А. Карбапенемоустойчивые штаммы Pseudomonas aeruginosa в стационарах города Пермь. Клин микробиол антимикроб химиотер 2010; 12(3):246-52.