Incidence of Community-Acquired Pneumonia and Acute Otitis Media in Children 0–5 Years in Russia and Role of S. pneumoniae or H. influenzae in the Etiology of the Diseases | CMAC

Incidence of Community-Acquired Pneumonia and Acute Otitis Media in Children 0–5 Years in Russia and Role of S. pneumoniae or H. influenzae in the Etiology of the Diseases

Clinical Microbiology and Antimicrobial Chemotherapy. 2013; 15(4):246-260

​ Kozlov R.S., Krechikova O.I., Muravyev A.A., Mironov K.O., Platonov A.E., Dunaeva E.A., Tatochenko V.K., Shcerbakov M.E., Rodnikova V.Y., Romanenko V.V., Safianov K.N., Study Group «PAPIRUS»
S. pneumoniae H. influenzae acute otitis media community-acquired pneumonia conjugated pneumococcal vaccines morbidity
Section
Diseases and Pathogens
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2013; 15(4):246-260

Objective.

To estimate the incidence of communityacquired pneumonias and acute otitis media and the role of S. pneumoniae and H. influenzae in these infections in children under 5 years.

Materials and Methods.

Investigational program PAPIRUS (Prospective Assessment of Pneumococcal Infection in RUSsia), which included multi-center prospective epidemiological study estimating the incidence of community-acquired pneumonia (CAP) and the role of S. pneumoniae and H. influenzae in CAP and acute otitis media (AOM) in children 0-5 years of age in 3 Russian cities (Barnaul, Yekaterinburg and Murmansk) and the prospective multi-center observational cohort study evaluating the incidence of AOM in children under 5 years in the same cities had been performed during 12 months.

Results.

The incidence of CAP (according to the WHO definition) in the center was more than 530 cases per 100 000 of children under 5 years. The incidence of AOM (confirmed by otolaryngologist) was 27.2 cases per 100 children-years or 2.27 cases on 100 children-months.

Conclusions.

The incidence of AOM and CAP in children under 5 years of age in Russia is a significant public health problem, and S. pneumoniae plays a leading role in the development of these diseases. Implementing modern conjugated pneumococcal vaccines into National Immunization Program will significantly reduce the incidence of the diseases.

  • 1. WHO position paper on Haemophilus influenzae type b conjugate vaccines. Wkly Epidemiol Rec 2006; 81(47):445-52.
  • 2. Pneumococcal conjugate vaccine for childhood immunization--WHO position paper. Wkly Epidemiol Rec 2007; 82(12):93-104.
  • 3. Козлов Р.С., Чагарян А.Н., Козлова Л.В., МуравьёвА.А. Cерологическая характеристика и чувствительность к антибиотикам пневмококков, выделенных у детей в возрасте до 5 лет в отдельных регионах Российской Федерации. Клин микробиол антимикроб химиотер 2011; 13(2):177-87.
  • 4. Inostroza J., Trucco O., Prado V., et al. Capsular serotype and antibiotic resistance of Streptococcus pneumoniae isolates in two Chilean cities. Clin Diagn Lab Immunol 1998; 5(2):176-80.
  • 5. Bennett J.V, Platonov A.E., Slack M.P.E., Mala P., Burton A.H., Robertson S.E. Haemophilus influenzae type b (Hib) meningitis in the pre-vaccine era: a global review of incidence, age distribution, and case-fatality rates. Document WHO/V&B/02.18. Geneva, World Health Organization, 2002. P.1-92. http://whqlibdoc.who.int/hq/2002/WHO_V&B_02.18.pdf
  • 6. Миронов К.О., Платонов А.Е., Козлов Р.С. Идентификация и серотипирование российских штаммов Streptococcus pneumoniae методом ПЦР. Клин микробиол антимикроб химиотер 2011; 13 (4):304-13.
  • 7. Приказ Минздравсоцразвития РФ от 31.01.2011 N 51н «Об утверждении национального календаря профилактических прививок и календаря профилактических прививок по эпидемическим показаниям».
  • 8. WHO. Standardization of interpretation of chest radiographs for the diagnosis of pneumonia in children. World Health Organization (WHO) Pneumonia Vaccine Trial Investigators group. World Health Organization; 2004. WHO/V&B/01.35.
  • 9. Yagupsky P., Porat N., Fraser D., et al. Acquisition, carriage, and transmission of pneumococci with decreased antibiotic susceptibility in young children attending day care facility in southern Israel J Infect Dis 1998; 177:1003-12.
  • 10. Johnson H.L., Deloria-Knoll M., Levine O.S., et al. Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project. PLoS Med;7(10): e1000348.
  • 11. O’Brien K.L., Nohynek H. Report from a WHO Working Group: standard method for detecting upper respiratory carriage of Streptococcus pneumoniae. Pediatr Infect Dis J 2003; 22(2):e1-11.
  • 12. Gribben B., Salkeld L.J., Hoare S., Jones H.F. The incidence of acute otitis media in New Zealand children under five years of age in the primary care setting. J Prim Health Care 2012; 4(3):205-12.
  • 13. Arguedas A., Kvaerner K., Liese J., et al. Otitis media across nine countries: disease burden and management. Int J Pediatr Otorhinolaryngol 2010; 74(12):1419-24.
  • 14. Sierra A., Lopez P., Zapata M.A., et al. Non-typeable Haemophilus influenzae and Streptococcus pneumoniae as primary causes of acute otitis media in Colombian children: a prospective study. BMC Infect Dis 2011; 11:4.
  • 15. Palmu A.A.I., Jokinen J.T., Kaijalainen T., Leinonen M., Karma P., Kilpi T.M. Association of clinical signs and symptoms with pneumococcal acute otitis media by serotype - implications for vaccine effect. Clin Infect Dis 2005; 40:52-7.
  • 16. Fenoll A., Jado I., Vicioso D., Berron S., Yuste J.E., Casal J. Streptococcus pneumonia in children in Spain: 1990– 1999. Acta Paediatr Suppl 2000; 435:44-50.
  • 17. Zissis N.P., Syriopoulou V., Kafetzis D., et al. Serotype distribution and antimicrobial susceptibility of Streptococcus pneumonia causing invasive infections and acute otitis media in children. Eur J Pediatr, 2004; 163:364-8.
  • 18. Prymula R., Motlova J., Kriz P. Comparison of Streptococcus pneumoniae serotypes causing acute otitis media & invasive disease in young children in the Czech Republic. Indian J Med Res 2004; 119:168-70.
  • 19. Clark J., Hammal D., Hampton F., Spenser D., . Parker L. Epidemiology of community-acquired pneumonia in children seen in hospital. Epidemiol Infect; 2007; 135(2):262-9.
  • 20. Weigl J.A., Bader H.M., Everding A., Schmitt H.J. Population-based burden of pneumonia before school entry in Schleswig-Holstein, Germany. Eur J Pediatr 2003; 162(5):309-16.
  • 21. Hausdorff W.P., Bryant J., Paradiso P.R., Siber G.R. Which pneumococcal serogroups cause the most invasive disease: implications for conjugate vaccine formulation and use, part I. Clin Infect Dis 2000; 30(1):100-21.
  • 22. St Sauver J., Marrs C.F., Foxman B., Somsel P., Madera R., Gilsdorf J.R. Risk factors for otitis media and carriage of multiple strains of Haemophilus influenzae and Streptococcus pneumoniae. Emerg Infect Dis; 2000; 6(6):622-30.
  • 23. Vaccine preventable deaths and the global immunization vision and strategy, 2006-2015. MMWR Morb Mortal Wkly Rep; 2006; 55:511-5.
  • 24. Reinert R.R. Pneumococcal conjugate vaccines - a European perspective. Int J Med Microbiol 2004; 294(5):277-94.
  • 25. Weigl J.A., Bader H.M., Everding A., Schmitt H.J. Population-based burden of pneumonia before school entry in Schleswig-Holstein, Germany. Eur J Pediatr 2003; 162(5):309-16.
  • 26. Ishiwada N., Kurosaki T., Terashima I., Kohno Y. The incidence of pediatric invasive pneumococcal disease in Chiba prefecture, Japan (2003 – 2005). J Infect 2008; 359:254-8
  • 27. MacIntyre C.R., McIntyre P. B., Cagney M. Communitybased estimates of incidence and risk factors for childhood pneumonia in Western Sydney. Epidemiol Infect 2003; 131(3):1091-6.
  • 28. Miguel W.. Demonstration of 10-vallent pneumococcal non-typable Haemophilus influenzae protein-D conjugate vaccine (PHiD-CV) efficacy against communityacquired pneumonia in Latin America: COMPAS results. SLIPE 2011. Abstr. 109563.
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