Abstract
Acute bacterial rhinosinusitis (ABRS) is a common disease in pediatric practice, which takes a fifth place among the causes of antimicrobials administration to children. This paper presents a review of current clinical guidelines on the management of children with ABRS, which have been developed over the last decade. Etiology and spectrum of microorganisms causing ABRS are considered. The paper provides international and Russian data on antimicrobial resistance among the most common pathogens of ABRS – S. pneumoniae and H. influenzae. Clinical diagnosis of ABRS in children as well as the other diagnostic examinations (radiological and microbiological) is described in detail. The main focus is made on antimicrobial therapy of ABRS, particularly a choice of antibiotic (based on severity, risk factors, and regional/ local antimicrobial resistance data) and its dosing regimen. Symptomatic management and adjunctive therapy issues are also considered.
-
1.
Anand V.K. Epidemiology and economic impact of rhinosinusitis. Ann Otol Rhinol Laryngol 2004; 193 (suppl):S3-5.
-
2.
Лечебно-диагностическая тактика при остром бактериальном синусите. Методические рекомендации Департамента здравоохранения Москвы. Сост. Крюков А.И. и соавт. Москва; 2002. 15 с.
-
3.
Anon J.B., Jacobs M.R., Poole M.D., et al. Sinus and allergy health partnership. Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.Otolaryngol Head Neck Surg 2004; 130 (Suppl 1):1-45.
-
4.
Hsueh P.R., Huang W.K., Shyr J.M., et al. Multicenter surveillance of antimicrobial resistance of Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis to 14 oral antibiotics. J Formos Med Assoc 2004; 103 (9):664-70.
-
5.
Gliklich R.E., Metson R. The health impact of chronic sinusitis in patients seeking otolaryngologic care. Otolaryngol Head Neck Surg 1995; 113:104-9.
-
6.
Slavin R.G., Spector S.L., Bernstein I.L., et al. American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. The diagnosis and management of sinusitis: a practice parameter update. J Allergy Clin Immunol 2005; 116 (6 Suppl):S13-47.
-
7.
Ray N.F., Baraniuk J.N., Thamer M. Healthcare expenditures for sinusitis in 1996: contributions of asthma, rhinitis, and other airway disorders. J Allergy Clin Immunol 1999; 103:408-14.
-
8.
American Academy of Pediatrics. Subcommittee on Management of Sinusitis and Committee on Quality Improvement. Clinical practice guideline: management of sinusitis. Pediatrics 2001; 108(3):798-808.
-
9.
Blomgren K., Alho O.P., Ertama L., et al. Acute sinusitis: finnish clinical practice guidelines. Scandinav J Infect Diseas 2005; 37(4):245-50.
-
10.
Zacharisen M., Casper R. Pediatric Sinusitis. Immumol Allergy Clinics North Am 2005; 25:313-32.
-
11.
Esposito S., Principi N., Italian Society of Pediatrics, et al. Guidelines for the diagnosis and treatment of acute and subacute rhinosinusitis in children. J Chemother 2008; 20(2):147-57.
-
12.
Богомильский М.Р., Чистякова В.Р. Детская оториноларингология. М: ГЭОТАР-МЕД, 2001; 430 с.
-
13.
Wald E.R., Guerra N., Byers C. Upper respiratory tract infections in young children: duration of and frequency of complications. Pediatrics 1991; 87:129–33.
-
14.
Revai K., Dobbs L.A., Nair S., et al. Incidence of acute otitis media and sinusitis complicating upper respiratory tract infection: the effect of age. Pediatrics 2007; 119(6):e1408-12.
-
15.
Гаращенко Т.И., Богомильский М.Р., Радциг Е.Ю. с соавт. Профилактика и лечение инфекций верхних дыхательных путей у детей. Лечащий врач 2001; 10:
-
16.
Гаращенко Т.И. Результаты многоцентрового исследования по применению препарата ИРС19 в профилактике ЛОР-заболеваний у часто болеющих детей (ЧБД). Юбилейный сборник научных трудов «Актуальные вопросы оториноларингологии детского возраста и фармакотерапия болезней ЛОР-органов», Москва, 2001.
-
17.
Hakim H.E., Malik A.C., Aronyk K., et al. The prevalence of intracranial complications in pediatric frontal sinusitis. Int J Pediatr Otorhinolaryngol 2006; 70(8):1383-7.
-
18.
Каманин Е.И., Отвагин И.В., Козлов Р.С. с соавт. Острый бактериальный риносинусит. Клин микробиол антимикроб химиотер 2008; 10 (1):34-45.
-
19.
Янов Ю.К., Рязанцев С.В., Страчунский Л.С. с соавт. Практические рекомендации по антибактериальной терапии синусита. Clinical Microbiology and Antimicrobial Chemotherapy.2003; 5(2):167-74.
-
20.
Scheid D.С., Hamm R.M. Acute bacterial rhinosinusitis in adults: part I. Evaluation. Am Fam Physician 2004; 70 (9):1685-92.
-
21.
Scheid D.C., Hamm R.M. Acute bacterial rhinosinusitis in adults: part II. Treatment. Am Fam Physician. 2004; 70(9):1697-704.
-
22.
EAACI Position Paper on Rhinosinusitis and Nasal Polyps Executive Summary. Allergy 2005:60:583-601.
-
23.
Chow A.W., Benninger M.S., Brook I., et al, Infectious Diseases Society of America. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis 2012; 54(8):e72-e112.
-
24.
Agence Française de Securité Sanitaire des Produits de Santé. Systemic antibiotic treatment in routine practice. Exacerbated chronic bronchitis, lower respiratory tract infections in children, acute otitis media, acute sinusitis in children, acute sinusitis in adults. Rev Pneumol Clin 2001; 57(5):323-7.
-
25.
Brooks I., Gooch W.M., Jenkins S.G., et al. Medical management of acute bacterial sinusitis. Recommendations of a clinical advisory committee on pediatric and adult sinusitis. Ann Otol Rhinol Laryngol 2000 (suppl.); 182:2-20.
-
26.
Беликов А.С. Фармакоэпидемиология антибактериальной терапии острых отоларингологических инфекций. Автореф. дисс.… канд. мед. наук. Смоленск, 2001; 23 с.
-
27.
Гиссенс И.К. Оценка качества антимикробной химиотерапии. Клин микробиол антимикроб химиотер 2001; 3 (2):133-47.
-
28.
Козлов С.Н., Беликов А.С. Анализ фармакотерапии острого синусита и острого среднего отита у взрослых пациентов. Клин фармакол терап. 2001; 10(5):48-51.
-
29.
Отвагин И.В. Фармакоэпидемиологическое и клинико-бактериологическое обоснование применения цефалоспоринов у больных с острым синуситом. Автореф. дисс. … канд. мед. наук. Смоленск, 1998. 22 с.
-
30.
Steele R.W. Chronic sinusitis in children. Clin Pediatr 2005; 44 (6):465-71.
-
31.
Costa Carvalho B.T., Nagao A.T., Arslanian C.,et al. Immunological evaluation of allergic respiratory children with recurrent sinusitis. Pediatr Allergy Immunol 2005; 16 (6):534-8.
-
32.
Страчунский Л.С. Каманин Е.И. Антибактериальная терапия инфекций в оториноларингологии. Русский медицинский журнал 1998; 6:684-93.
-
33.
Evans K.L. Recognition and management of sinusitis. Drugs 1998; 56(1):59-71.
-
34.
Huang W.H., Fang S.Y. High prevalence of antibiotic resistance in isolates from the middle meatus of children and adults with acute rhinosinusitis. Am J Rhinol 2004; 18 (6):387-91.
-
35.
Takenaka M., Morikawa Y., Nakagawa T., et al. Causative organisms of acute otitis media and acute sinusitis in children and their susceptibility of oral beta-lactam antibiotics. Jpn J Antibiot 1999; 52 (2):162-71.
-
36.
Wald E.R. Sinusitis in children. N Engl J Med 1992; 326:319-23.
-
37.
Anon J.B. Acute bacterial rhinosinusitis in pediatric medicine: current issues in diagnosis and management. Paediatr Drugs 2003; 5 (Suppl 1):25-33.
-
38.
Payne S.C., Benninger M.S. Staphylococcus aureus is a major pathogen in acute bacterial rhinosinusitis: a metaanalysis. Clin Infect Dis 2007; 45(10):e121-7.
-
39.
Страчунский Л.С., Тарасов А.А., Крюков А.И. с соавт. Возбудители острого бактериального синусита. Результаты многоцентрового микробиологического исследования SSSR. Clinical Microbiology and Antimicrobial Chemotherapy.2005; 7(4):337-49.
-
40.
Blasi F., Farrell D.J., Dubreuil L. Antibacterial activity of telithromycin and comparators against pathogens isolated from patients with community- acquired respiratory tract infections: the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin study year 5 (2003-2004). Diagn Microbiol Infect Dis 2009; 63(3):302–10.
-
41.
Козлов Р.С., Сивая О.В., Кречикова О.И., Иванчик Н.В. и группа исследователей проекта «ПеГАС» Динамика резистентности Streptococcus pneumoniae к антибиотикам в России за период 1999-2009 гг. Клин микробиол антимикроб химиотер 2010; 12(4):329-41.
-
42.
Козлов Р.С. Пути оптимизации мониторинга, профилактики и фармакотерапии пневмококковых инфекций. Автореф. дисс.… докт. мед. наук. – Смоленск, 2004. - 46 стр.
-
43.
Kozlov R.S., Sivaja O.V. Antimicrobial resistance of clinical H. influenzae in Russia: Results of prospective multicenter study (PEhASus) Proceedings of the 8th European Congress of Chemotherapy and Infection and 4th European Conference on Viral Diseases, 25-28 October 2006, Budapest, Hungary. – P. 116.
-
44.
Андреева И.В., Стецюк О.У. Международные рекомендации по ведению взрослых пациентов с острым бактериальным риносинуситом: применимы ли они в России? Фарматека 2006, 11 (126):72-6.
-
45.
Ciprandi G., Tosca M.A., Fasce L. Allergic children have more numerous and severe respiratory infections than non-allergic children. Ped Allergy Immunol 2006; 17:389-91.
-
46.
Hakansson K., Thomsen S.F., Ulrik C.S., et al. Increase in the prevalence of rhinitis among Danish children from 1986 to 2001. Pediatr Allergy Immunol 2007; 18(2):154-9.
-
47.
Тарасов А.А., Каманин Е.И., Крюков А.И., с соавт. Острый бактериальный риносинусит: современные подходы к диагностике и антибактериальной терапии в амбулаторных условиях. Клин микробиол антимикроб химиотер 2002; 4(1):70-82.
-
48.
Okuyemi K.S., Tsue T.T. Radiologic imaging in the management of sinusitis. Am Fam Physician 2002; 66 (10):1882-6.
-
49.
Diament M.J. The diagnosis of sinusitis in infants and children: x-ray, computed tomography, and magnetic resonance imaging. Diagnostic imaging of pediatric sinusitis. J Allergy Clin Immunol 1992; 90:442-4.
-
50.
Kronemer K.A., McAlister W.H. Sinusitis and its imaging in the pediatric population. Pediatr Radiol 1997; 27(11):837-46.
-
51.
Triulzi F., Zirpoli S. Imaging techniques in the diagnosis and management of rhinosinusitis in children. Pediatr Allergy Immunol 2007; 18 (Suppl. 18):46-9.
-
52.
Dammann F. Imaging of paranasal sinuses today. Radiologe. 2007; 47(7):576, 578-83
-
53.
Reid J.R. Complications of pediatric paranasal sinusitis. Pediatr Radiol 2004; 34(12):933-42.
-
54.
Vázquez E., Creixell S., Carreño J.C., et al Complicated acute pediatric bacterial sinusitis: Imaging updated approach. Curr Probl Diagn Radiol. 2004; 33(3):127-45.
-
55.
Каманин Е.И., Стецюк О.У. Инфекции верхних дыхательных путей и ЛОР-органов. Практическое руководство по антиинфекционной химиотерапии. Под ред. Страчунского Л.С., Белоусова Ю.Б., Козлова С.Н. Смоленск, МАКМАХ, 2007:248-58.
-
56.
Sinus and Allergy Health Partnership. Antimicrobial treatment guidelines for acute bacterial rhinosinusitis. Otolaryngol Head Neck Surg 2000; 123 (1):1-32.
-
57.
Brook I. The role of anaerobic bacteria in sinusitis. Anaerobe 2006; 12(1):5-12.
-
58.
Unlu H.H., Eskiizmir G., Tarhan S., Ovali G.Y. Assessment of symptomatic patients after endoscopic sinus surgery with special reference to the frontal sinus: comparative radiologic analysis. J Otolaryngol 2006; 35(4):261-9.
-
59.
Gelardi M., Fiorella M.L., Leo G., Incorvaia C. Cytology in the diagnosis of rhinosinusitis. Pediatr Allergy Immunol 2007; 18 (Suppl. 18):50-2.
-
60.
Marseglia G.L., Pagella F., Licari A., et al. Acute isolated sphenoid sinusitis in children. Int J Pediatr Otorhinolaryngol 2006; 70(12):2027-31.
-
61.
Laine K., Maata T., Voronen H., et al. Diagnosing acute. maxillary sinusitis in primary care: a comparison of ultra-. sound, clinical examination and ultrasound for diagnosis of sinusitis. Rhinology 1998; 26:2-6.
-
62.
Osguthorpe J.D. Sinus neoplasia. Arch Otolaryngol Head Neck Surg 1994; 120:19-25.
-
63.
Gwaltney J.M. Acute community acquired bacterial sinusitis: to treat or not to treat. Can Respir J 1999; 6 (Suppl A):46A-50A.
-
64.
Garbutt J.M., Goldstein M., Gellman E., et al. A randomized, placebo-controlled trial of antimicrobial treatment for children with acute sinusitis. Pediatrics 2001; 107:619-25.
-
65.
Georgalas C., Thomas K., Owens C., et al. Medical treatment for rhinosinusitis associated with adenoidal hypertrophy in children: an evaluation of clinical response and changes on magnetic resonance imaging. Ann Otol Rhinol Laryngol 2005; 114(8):638-44.
-
66.
Leo G., Piacentini E., Incorvaia C., et al. Chronic rhinosinusitis and allergy. Pediatr Allergy Immunol 2007; 18 (Suppl 18):19-21.
-
67.
Kristo A., Uhari M., Luotonen J., Ilkko E., Koivunen P., Alho O.P.Cefuroxime axetil versus placebo for children with acute respiratory infection and imaging evidence of sinusitis: a randomized, controlled trial. Acta Paediatr 2005; 94:1208-13.
-
68.
Pichichero M.E., Cohen R. Shortened course of antibiotic therapy for acute otitis media, sinusitis and tonsillopharyngitis. Pediatr Infect Dis J 1997; 16(7):680-95.
-
69.
Wald E.R., Reilly J.S., Casselbrant M., et al Treatment of acute maxillary sinusitis in childhood: a comparative study of amoxicillin and cefaclor. J Pediatr1984; 104:297- 302
-
70.
Morris P., Leach A. Antibiotics for persistent nasal discharge (rhinosinusitis) in children. Cochrane Database Syst Rev 2008; (3):CD001094.
-
71.
Rosenblut A., Santolaya M.E., Gonzalez P., Borel C., Cofre J. Penicillin resistance is not extrapolable to amoxicillin resistance in Streptococcus pneumoniae isolated from middle ear fluid in children with acute otitis media. Ann Otol Rhinol Laryngol 2006; 115(3):186-90.
-
72.
Novembre E., Mori F., Pucci N., et al. Systemic treatment of rhinosinusitis in children. Pediatr Allergy Immunol 2007; 18 (Suppl. 18):56-61.
-
73.
Duse M., Caminiti S., Zicari A.M. Rhinosinusitis: prevention strategies. Pediatr Allergy Immunol 2007; 18 (Suppl 18):71-4.
-
74.
Inanli S., Ozturk O., Korkmaz M., et al. The effects of topical agents of fluticasone propionate, oxymetazoline, and 3% and 0.9% sodium chloride solutions on mucociliary clearance in the therapy of acute bacterial rhinosinusitis in vivo. Laryngoscope 2002; 112:320-5.
-
75.
McCormick D.P., John S.D., Swischuk L.E., et al. A double-blind, placebo controlled trial of decongestantantihistamine for the treatment of sinusitis in children. Clin Pediatr (Phila). 1996; 35:457-60.
-
76.
Wiklund L., Stierna P., Berglund R., et al. The efficacy of oxymetazoline administered with a nasal bellows container and combined with oral phenoxymethyl-penicillin in the treatment of acute maxillary sinusitis. Acta Otolaryngol (Suppl) 1994; 515:57-64.
-
77.
Basibuyuk T., Ozaydin E., Cengizlier R. Nasal cytology in the diagnosis and treatment of sinusitis in atopic and nonatopic children. J Otolaryngol 2006; 35 (4):255-60.
-
78.
Corren J., Kachru R. Relationship between nonallergic upper airway disease and asthma. Clin Allergy Immunol 2000; 19:101-14.
-
79.
Lai L., Hopp R.J., Lusk R.P. Pediatric chronic sinusitis and asthma: a review. J Asthma 2006; 43 (10):719-25.
-
80.
Barlan I.B., Erkan E., Bakir M., et al. Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children. Ann Allergy Asthma Immunol 1997; 78:598-601.
-
81.
Dolor R.J., Witsell D.L., Hellkamp A.S., et al. Comparison of cefuroxime with or without intranasal fluticasone for the treatment of rhinosinusitis. The CAFFS Trial: a randomized controlled trial. JAMA 2001; 286:3097-105.
-
82.
Meltzer E.O., Charous B.L., Busse W.W., et al. Added relief in the treatment of acute recurrent sinusitis with adjunctive mometasone furoate nasal spray. The Nasonex Sinusitis Group. J Allergy Clin Immunol 2000; 106:630- 7.
-
83.
Nayak A.S., Settipane G.A., Pedinoff A., et al. Effective dose range of mometasone furoate nasal spray in the treatment of acute rhinosinusitis. Ann Allergy Asthma Immunol 2002; 89:271-8.
-
84.
Kassel J.C., King D., Spurling G.K. Saline nasal irrigation for acute upper respiratory tract infections. Cochrane Database Syst Rev. 2010; (3):CD006821.