Ertapenem – a Newer Carbapenem | CMAC

Ertapenem – a Newer Carbapenem

Clinical Microbiology and Antimicrobial Chemotherapy. 2009; 11(1):40-55

​ Kozlov R.S., Nikulin A.A.
carbapenems ertapenem antimicrobial activity resistance pharmacokinetics
Section
Antimicrobials
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2009; 11(1):40-55

Abstract

The carbapenems are class of beta-lactam antibiotics with exceptionally wide spectrum of activity, beneficial pharmacokinetic parameters and low toxicity as well. Such agents as imipenem and meropenem have already been succesfully used for a long time in clinical practice for treatment of severe nosocomial infections. The ertapenem appeared in 2002 represent a new class of carbapenems. It has differences from precursors in antimicrobial spectrum, including activity against ESBL and AmpC-producing microorganisms, and improved pharmacokinetics with once daily dosing. This paper provides an overview of pharmacological, microbiological and clinical data on ertapenem.

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