Abstract
Methods to improve patient compliance with treatment are rarely used by physicians in their practice. It may be in part because of the lack of adequate information on this issue. This paper reviews adherence of the patients with respiratory tract infections to antimicrobial therapy. Analysis of currently available compliance assessment methods and common errors related to patient noncompliance with antimicorbial regimens was performed. The factors having effect on compliance and methods for improving patient compliance with the treatment recommendations are considered. The most effective methods for improving compliance are reduced dosing frequency and short-term courses of antimicrobial therapy. Given this, focus on new oral formulation of azithromycin (higher dose strength and extended release) is made. This oral form of azithromycin makes it possible to provide singledose treatment and achieve 100% compliance with the treatment.
-
1.
Pechere J.C., Hughes D., Kardas P., Cornaglia G. Non compliance with antibiotic therapy for acute community infections:a global survey. Int J of Antimicrob Agents 2007; 29:245-53.
-
2.
Kardas P. Patient compliance with antibiotic treatment for respiratory tract infections. Antimicrob Chemother 2002; 49:897-903.
-
3.
Insull W. J. The problem of compliance to cholesterol altering therapy. Int Med 1997; 241:317-25.
-
4.
Wandstrat T., Kaplan B. Pharmacoeconomic impact of factors affecting compliance with antibiotic regimens in the treatment of acute otitis media. Pediatric Inf Dis J 1997; 16:27-9.
-
5.
Horwitz R.I., Horwitz S.M. Adherence to treatment and health outcomes. Arch of Int Med 1993:153, 1863-8.
-
6.
Urquhart J. Pharmacoeconomic consequences of variable patient compliance with prescribed drug regimens. Pharmacoeconom. 1999;15:217-28.
-
7.
Granger B., Swedberg K., Ekman I., et al.; CHARM investigators. Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme:double-blind, randomised, controlled clinical trial. Lancet 2005; 366:2005-11.
-
8.
Daschner F., Marget W. Treatment of recurrent urinary tract infection in children. II. Compliance of parents and children with antibiotic therapy regimen. Acta Paediatr Scand 1975; 64:105-8.
-
9.
Charney E., Bynum R., Eldredge D., et al. How well do patients take oral penicillin? A collaborative study in private practice. Pediatr 1967; 40:188-95.
-
10.
Cockburn J., Reid A. L., Bowman J., Sanson-Fisher, R. Effects of intervention on antibiotic compliance in patients in general practice. Med J of Australia 1987; 147:324-8.
-
11.
Venuta A., Laudizi L., Beverelli A., et al. Azithromycin compared with clarithromycin for the treatment of streptococcal pharyngitis in children. J Int Med Res 1998; 26:152-8.
-
12.
Drehobl M.A., De Salvo M.C., Lewis D.E., Breen J.D. Single-dose azithromycin microspheres vs clarithromycin extended release for the treatment of mild-to-moderate community-acquired pneumonia in adults. Chest 2005;128:2230-7.
-
13.
Agarwal G, Awasthi S, Kabra SK, et al.; ISCAP Study Group. Three day versus five day treatment with amoxicillin for non-severe pneumonia in young children:a multicentre randomised controlled trial. Br Med J 2004; 328:791.
-
14.
Pakistan Multicentre Amoxycillin Short Course Therapy (MASCOT) pneumonia study group. Clinical efficacy of 3 days versus 5 days of oral amoxicillin for treatment of childhood pneumonia:a multicentre double-blind trial. Lancet 2002; 360:835-41.
-
15.
Cheung R., Sullens C.M., Seal D., et al. The paradox of using a 7 day antibacterial course to treat urinary tract infections in the community. Br J Clin Pharm 1988; 26:391-8.
-
16.
Green J., Ray S., Charney E. Recurrence rate of streptococcal pharyngitis related to oral penicillin. J Pediatr 1969; 75:292-4.
-
17.
Weis S., Slocum P., Blais F., et al. The effect of directly observed therapy on the rates of drug resistance and relapse in tuberculosis. N Engl J Med 1994; 330:1179-84.
-
18.
Sethi A.K., Celentano D.D., Gange S.J., Moore R.D., Gallant J.E. Association between adherence to antiretroviral therapy and human immunodeficiency virus drug resistance. Clin Infect Dis 2003; 37:1112-8.
-
19.
Доступно на UPL:http://ru-romir.livejournal.com/ 105671.html#cutid1.
-
20.
Cramer J.A., Scheyer R.D., Mattson R.H. Compliance declines between clinic visits. Arch of Int Med 1990; 150:1509-10.
-
21.
Cramer J. A. Microelectronic systems for monitoring and enhancing patient compliance with medication regimens. Drugs 1995; 49:321-7.
-
22.
Polla D.L., Erdman, A.G., Robbins, et al. Microdevices in medicine. Ann Rev of Biomed Engineer 2000; 2:551-76.
-
23.
Claxton A.J., Cramer, J., Pierce C.A systematic review of the association between dose regimens and medication compliance. Clin Ther 2001; 23:1296-310.
-
24.
Fallab-Stubi C.L., Zellweger J.P., Sauty A., et al. Electronic monitoring of adherence to treatment in the preventive chemotherapy of tuberculosis. Int J of Tuberc and Lung Dis 1998; 2:525-30.
-
25.
Wahl L.M., Nowak M.A. Adherence and drug resistance: predictions for therapy outcome. Proceedings of the Royal Society of London Series Biological Sciences 2000; 267:835-43.
-
26.
Favre O., Delacretaz E., Badan M., et al. Relationship between the prescriber’s instructions and compliance with antibiotherapy in outpatients treated for an acute infectious disease. Clin Pharm 1997; 37:175-8.
-
27.
Urquhart J. Ascertaining how much compliance is enough with outpatient antibiotic regimens. Postgraduate Med 1992; 68:49-58.
-
28.
Gil V.F., Paya M.A., Asensio M.A., et al. Non-compliance of the treatment with antibiotics in non-severe acute infections. Med Clin 1999; 112:31-3.
-
29.
Branthwaite A., Pechere J.C. Pan-European survey of patients’ attitudes to antibiotics and antibiotic use. Inter Med Resear 1996; 24:229-38.
-
30.
Greenberg R.N. Overview of patient compliance with medication dosing:a literature review. Clin Ther 1984; 6:592-9.
-
31.
Sclar D.A., Tartaglione T.A., Fine M.J. Overview of issues related to medical compliance with implications for outpatient management of infectious diseases. Inf Agents and Dis 1994; 3:266-73.
-
32.
Alvarez M.P., Simon M., Sanchez S., Apaloaza I., Prieto J. Pharmacovigilance study of azithromycin tablets (500 mg) in the treatment of adult patients with respiratory tract infections. Revista Espanola de Quimioter 2000; 13:297- 305.
-
33.
Kardas P., Ratajczyk-Pakalska E. Patient adherence in respiratory tract infections:ceftibuten versus other antibiotics (PARTICULAR study). Polski Merkuriusz Lekarski 2001; 10:445-9.
-
34.
Cook R., Zachariah J., Cree F., Harrison H. Efficacy of twicedaily amoxycillin/clavulanate (Augmentin-Duo 400/57) in mild to moderate lower respiratory tract infections in children. British J of Clin Pract 1996; 50:125-8.
-
35.
Ramalle-Gomara E., Bermejo-Ascorbe R., Alonso Marin R., et al. Compliance with antibiotic treatment in nonhospitalized children. Atencion Primaria 1999; 24:364-7.
-
36.
Lauvau D., Verbist L. An open, multicenter, comparative study of the efficacy and safety of azithromycin and coamoxiclav in the treatment of upper and lower respiratory tract infections in children. Pediatr Azithromycin Study Group. Intern Med Research 1997; 25:285-95.
-
37.
Kardas P. Compliance to antibiotics in out-patients treated for respiratory infections. Pneum Alerg Polska 1999; 67:398-408.
-
38.
Bergman A., Werner R. Failure of children to receive penicillin by mouth. New England J of Med 1963; 268:1334-8.
-
39.
Ellerbeck E., Khallaf N., Ansary K., et al. Caretaker compliance with different antibiotic formulations for treatment of childhood pneumonia. J of Tropical Pediatr 1995; 41:102-8.
-
40.
Tomiki Y., Kanay Y., Danbara T., et al. Survey of outpatient waiting time. Juntendoigaku 2003; 49:102-7.
-
41.
Kardas P., Devine S., Gollembesky A., Roberts C. A systematic review and meta-analysis of misure of antibiotic therapies in the community. Int J of Antimicrob Ag 2005; 26:106-13.
-
42.
Augenbraun M., Bachmann L., Wallace Т., et al. Compliance with doxycycline therapy in sexually transmitted diseases clinics. Sex Transm Dis 1998; 25:1- 4.
-
43.
Garey B., Gryan B. Antibiotic misuse in the community a contributor resistance? I Med J 2003; 96:43-5.
-
44.
Kardas P. Comparison of patient compliance with oncedayly and twice-daily antibiotic regimens in respiratory tract infections:result of a randomized trial. J Antimicrob Chemother 2007; 59:531-6.
-
45.
Girard D., Finegan S.M., Dunne M.W., Lame M.E. Enchanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models. J Antimicrob Chemother 2005; 56:365-71.
-
46.
D’Ignazio J., Camere M. A., Lewis D.E., et al. Novel, single-dose microsphere formulation of azithromycin versus 7-day levofloxacin therapy for treatment of mild to moderate community-acquired pneumonia in adults. Antimicrob Agents Chemother 2005; 49:4035-41.
-
47.
Rudd P., Lenert L. Pharmacokinetics as an aid to optimising compliance with medications. Clin Pharmacokinet 1995; 28:1-6.
-
48.
Pechere J.C., Lacey L. Optimizing economic outcomes in antibiotic therapy of patients with acute bacterial exacerbations of chronic bronchitis. Antimicrob Chemother 2000; 45:19-24.
-
49.
Nikolaus Т., Kruse W., Bach M., Specht-Leible, et al. Elderly patients problems with medication. An inhospital and follow-up study. Europ J of Clin Pharm 1996; 49:255-9.
-
50.
Lima J., Nazarian L., Charney E., Lahti C. Compliance with short-term antimicrobial therapy:some techniques that help. Pediatr 1976; 57:383-6.