Aetiology of Kawasaki Disease | CMAC

Aetiology of Kawasaki Disease

Clinical Microbiology and Antimicrobial Chemotherapy. 2002; 4(3):239-247

​ Bregel L.V., Subbotin V.M., Belozerov Yu.M.
Kawasaki disease Kawasaki systemic vasculitis Kawasaki syndrome mucocutaneous lymph node syndrome etiology
Section
Diseases and Pathogens
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2002; 4(3):239-247

Abstract

Kawasaki disease is hyperimmune vasculitis with presumably infectious origin. Predisposing factors are probably heredity and atopy. Although etiology of Kawasaki disease is still unknown, there are a lot of facts, arguing for the trigger role of infection in pathogenesis of this systemic disease. The different infectious agents, both superantigens of certain bacteria and conventional viral and/or microbial antigens are considered as a cause of Kawasaki disease. Moreover, one or more microorganisms, which are probably still unknown, may afflict host immunocompetence and develop clinical symptoms. However, in general, investigations were able not to prove or disprove any single theory. Therefore, there is an obvious need for further studies in this field of infectious diseases.

  • 1. Kawasaki T. Acute febrile MCLNS: Clinical observations of 50 cases. Jpn J Allergol 1967; 16:178-222.
  • 2. Kawasaki T., Kosaki F., Okawa S., et al. A new infantile acute febrile mucocutaneous lymph node syndrome (MCLNS) prevailing in Japan. Pediatrics 1974; 54:271-6.
  • 3. Брегель Л.В., Белозеров Ю.М., Субботин В.М. Болезнь Кавасаки у детей — первые клинические наблюдения в России. Рос вестн перинатол педиатр 1998; 43:25-30.
  • 4. Брегель Л.В. Коронариты (болезнь Кавасаки и недифференцированные формы) как основа раннего формирования ишемической болезни сердца в детском и молодом возрасте [диссертация]. М; 1998.
  • 5. Субботин В.М. Клинические проявления коронарита при болезни Кавасаки у детей в зависимости от локализации и характера коронарного поражения [диссертация]. М; 2001.
  • 6. Bronstein D.E., Dille A.N., Austin J.R., et al. Relationship of climate ethnicity and socioeconomic status of Kawasaki disease. Pediatr Infect Dis J 2000; 19 (11):1087-91.
  • 7. Yanagawa H., Yashiro M., Nakamura Y., Kawasaki T., Kato H. Epidemiologic pictures of Kawasaki disease in Japan: from the nationwide incidence survey in 1991 and 1992. Pediatrics 1995; 95 (4):475-9.
  • 8. Hirata S., Nakamura Y., Yanagawa H. Incidence rate of recurrent Kawasaki disease and related risk factors: from the results of nationwide surveys of Kawasaki disease in Japan. Acta Paediatr 2001; 90:40-4.
  • 9. Yanagawa H., Yashiro M., Nakamura Y., Kawasaki T., Kato H. Results of 12 nationwide epidemiological incidence surveys of Kawasaki disease in Japan. Arch Pediatr Adolesc Med 1995; 149 (7):779-83.
  • 10. Dean A.G., Melish M.E., Hicks R., Palumbo N.E. An epidemic of Kawasaki syndrome in Hawaii. J Pediatr 1982; 100 (4):552-7.
  • 11. Bell D.M., Morens D.M., Holman R.C., Hurwitz E.S., Hunter M.K. Kawasaki syndrome in the United States 1976 to 1980. Am J Dis Child 1983; 137 (3):211-4.
  • 12. Salo E., Pelkonen P., Pettay O. Outbreak of Kawasaki syndrome in Finland. Acta Paediatr Scand 1986; 75 (1):75-80.
  • 13. Schiller B., Fasth A., Bjorkhem G., Elinder G. Kawasaki disease in Sweden: incidence and clinical features. Acta Paediatr 1995; 84 (7):769-74.
  • 14. Carman P.G., Menahem S. Possible «outbreak» of Kawasaki disease in Victoria. Med J Aust 1983; 2 (4):183-5.
  • 15. Smith P.K., Goldwater P.N. Kawasaki disease in Adelaide: a review. J Paediatr Child Health 1993; 29 (2):126-31.
  • 16. Tamburlini G. Strinati R. Cadorini S., et al. A two-year survey of mucocutaneous lymph node syndrome in northeastern Italy. Epidemiological and clinical findings. Helv Paediatr Acta 1984; 39 (4):319-29.
  • 17. Tsuchida S., Yamanaka T., Tsuchida R., et al. Epidemiology of infant Kawasaki disease with a report of the youngest neonatal case ever reported in Japan. Acta Paediatr 1996; 85 (8):995-7.
  • 18. Horstmann E., Daweke H. Mucocutaneous lymph node syndrome (Kawasaki disease) in adults. MMW Münch Med Wochenschr 1982; 124:909-10.
  • 19. Wortmann D.W. Kawasaki syndrome. Semin Dermatol 1992; 11 (1):37-47.
  • 20. Bell D.M., Brink E.W., Nitzkin J.L., et al. Kawasaki syndrome: description of two outbreaks in the United States. N Engl J Med 1981; 304:1568-75.
  • 21. Jacobs J.C. Kawasaki disease. Curr Opin Rheumatol 1996; 8 (1):41-3.
  • 22. Leung D.Y., Meissner C., Fulton D., Schlievert P.M. The potential role of bacterial superantigens in the pathogenesis of Kawasaki syndrome. J Clin Immunol 1995; 15(6 Suppl):11S-7S.
  • 23. Abe Y., Nakano S., Nakahara T., et al. Detection of serum antibody by the antimitogen assay against streptococcal erythrogenic toxins. Age distribution in children and the relation to Kawasaki disease. Pediatr Res 1990; 27 (1):11-15.
  • 24. Abinun M., Cant A.J. Toxic shock syndrome toxinsecreting Staphylococcus aureus in Kawasaki syndrome [letter]. Lancet 1994; 343:300.
  • 25. Curtis N., Zheng R., Lamb J.R., Levin M. Evidence for a superantigen mediated process in Kawasaki disease. Arch Dis Child 1995; 72(4):308-11.
  • 26. Shen C.T., Wu H.Y., Wang N.K., Huang C.S. Reevaluation of streptococcal infection in the pathogenesis of Kawasaki disease. Acta Paediatr Sin 1990; 31(3):144-50.
  • 27. Akiyama T., Yashiro K. Probable role of Streptococcus pyogenes in Kawasaki disease. Eur J Pediatr 1993; 152(2):82-92.
  • 28. Anderson D.G., Warner G., Barlow E. Kawasaki disease associated with streptococcal infection within a family. J Paediatr Child Health 1995; 31(4):55-7.
  • 29. Burnell R.H. Kawasaki disease with streptococcal infection [letter] J Paediatr Child Health 1996; 32 (3):270.
  • 30. Tsurumizu T., Okonogi H., Shibusawa T., et al. A case of Kawasaki disease combined with septicemia-isolation of Streptococcus sanguis and Streptococcus pyogenes from blood at the acute stage. Kansenshogaku Zasshi 1991; 65 (1): 124-8.
  • 31. Yanase Y. Critique on the streptococcal infection theory for the cause of Kawasaki disease. Nippon Rinsho 1983; 41(9):2057-62.
  • 32. Terai M., Miwa K., Williams T., Kabat W., et al. The absence of evidence of staphylococcal toxin involvement in the pathogenesis of Kawasaki disease. J Infect Dis 1995; 172 (2):558-61.
  • 33. Todome Y., Ohkuni H., Mizuse M., et al. Superantigenic exotoxin production by isolates of Staphylococcus aureus from the Kawasaki syndrome patients and age-matched control children. J Med Microbiol 1995; 42(2):91-5.
  • 34. Pietra B.A., De Inocencio J., Giannini E.H., Hirsch R. TCR V beta family repertoire and T cell activation markers in Kawasaki disease. J Immunol 1994; 153:1881-8.
  • 35. Leung D.Y. Superantigens related to Kawasaki syndrome. Springer Semin Immunopathol 1996; 17 (4):385-96.
  • 36. Leung D.Y. Immunologic abnormalities in Kawasaki syndrome. Prog Clin Biol Res 1987; 250:159-65.
  • 37. Keren G., Barzilay Z., Alpert G., Spirer Z., Danon Y. Mucocutaneous lymph node syndrome (Kawasaki disease) in Israel. A review of 13 cases: is pseudomonas infection responsible? Acta Paediatr Scand 1983; 72 (3):455-8.
  • 38. Tasaka K., Hamashima Y. Studies on rickettsia-like body in Kawasaki disease. Attempts of the isolation and characterization. Acta Pathol Jpn 1978; 28 (2):235-45.
  • 39. Shishido A. Failure to confirm the rickettsial etiology of MCLS (Kawasaki disease). Jpn J Med Sci Biol 1979; 32 (4):250-1.
  • 40. Keren G., Cohen B.E., Barzilay Z., Hiss J., Wolman M. Kawasaki disease and infantile polyarteritis nodosa: is Pseudomonas infection responsible? Report of a case. Isr J Med Sci 1979; 15 (7):592-600.
  • 41. Keren G., Wolman M. Can pseudomonas infection in experimental animals mimic Kawasaki disease? J Infect 1984; 9 (1):22-9.
  • 42. Tomita S., Kato H., Fujimoto T., Inoue O., Koga Y., Kuriya N. Cytopathogenic protein in filtrates from cultures of Propionibacterium acnes isolated from patients with Kawasaki disease. Br Med J 1987; 295:1229-32.
  • 43. Sireci G., Dieli F., Salerno A. T cells recognize an immunodominant epitope of heat shock protein 65 in Kawasaki disease. Mol Med 2000; 6 (7):581-90.
  • 44. Johnson D., Azimi P. Kawasaki disease associated with Klebsiella pneumoniae bacteremia and parainfluenza type 3 virus infection. Pediatr Infect Dis 1985; 4 (1):100.
  • 45. Khono T., Takase Y., Niki H. Chlamydia infections in Kawasaki disease. Acta Paediatr Jpn 1991; 33(3):408-10.
  • 46. Takeshita S., Kawase H., Shimizu T., Yoshida M., Sekine I. Increased production of serum IgA-class antibody to lipid A in Kawasaki disease. Pediatr Int 2002;44:5-11.
  • 47. Rathore M.H., Barton L.L., Dawson J.E., Regnery R.L., Ayoub EM Ehrlichia chaffeensis and Rochalimaea antibodies in Kawasaki disease. J Clin Microbiol 1993; 31(11):3058-9.
  • 48. Kuratsuji T., Takagi K., Tsunawaki S. Etiological role of phagocytes in Kawasaki disease. Acta Paediatr Jpn 1991; 33 (6):778-84.
  • 49. Nigro G.. Midulla M. Retrovirus and Kawasaki disease [letter]. Lancet 1986; 8514:1045.
  • 50. Rowley A., Castro B., Levy J., et al. Failure to confirm the presence of a retrovirus in cultured lymphocytes from patients with Kawasaki syndrome. Pediatr Res 1991; 29 (5):417-9.
  • 51. Holm J.M., Hansen L.K., Oxhj H. Kawasaki disease associated with parvovirus B19 infection. Eur J Pediatr 1995; 154 (8):633-4.
  • 52. Nigro G., Zerbini M., Krzysztofiak A., et al. Active or recent parvovirus B19 infection in children with Kawasaki disease. Lancet, 1994; 8908:1260-1.
  • 53. Nigro G., Pisano P., Krzysztofiak A. Recurrent Kawasaki disease associated with co-infection with parvovirus B19 and HIV-1 [letter]. AIDS, 1993; 7 (2)288-90.
  • 54. Kikuta H., Matsumoto S., Yanase Y., Kawasaki T., Mizuno F., Osato T. Recurrence of Kawasaki disease and Epstein–Barr virus infection [letter]. J Infect Dis 1990; 162 (5):1215.
  • 55. Kikuta H., Taguchi Y., Tomizawa K., et al. Epstein–Barr virus genome-positive T lymphocytes in a boy with chronic active EBV infection associated with Kawasakilike disease. Nature 1988; 333:455-7.
  • 56. Kikuta H., Matsumoto S., Osato T. Kawasaki disease and Epstein – Barr virus. Acta Paediatr Jpn 1991; 33(6): 765-70.
  • 57. Kanegane H., Tsuji T., Seki, et al. Kawasaki disease with a concomitant primary Epstein–Barr virus infection. Acta Paediatr Jpn 1994; 36 (6):713-6.
  • 58. Culora G.A., Moore I.E. Kawasaki disease, Epstein–Barr virus and coronary artery aneurysms. J Clin Pathol 1997; 50 (2):161-3.
  • 59. Okano M., Luka J., Thiele G.M., et al. Human herpesvirus 6 infection and Kawasaki disease. J Clin Microbiol 1989; 27 (10):2379-80.
  • 60. Marchette N.J., Melish M.E., Hicks R., Kihara S., Sam E., Ching D. Epstein–Barr virus and other herpesvirus infections in Kawasaki syndrome. J Infect Dis 1990; 162 (2):573.
  • 61. Umehara K., Kuno-Sakai H., Iwasaki H., et al. Trial of isolation of a virus from sera of patients with Kawasaki disease. Tokai J Exp Clin Med 1986; 11 (1):19-21.
  • 62. Blum-Hoffmann E., Hoffmann G.F., Wessel A., Gahr M. Kawasaki syndrome. Association with exposure to carpet shampoo and successful therapy with immunoglobulins in the second week of the illness. Monatsschr Kinderheilkd 1992; 140 (5):273-6.
  • 63. Patriarca P.A., Rogers M.F., Morens D.M., et al. Kawasaki syndrome: association with the application of rug shampoo. Lancet 1982; 8298:578-80.
  • 64. Rauch A.M., Glode M.P., Wiggins J.W. Jr., et al. Outbreak of Kawasaki syndrome in Denver, Colorado: association with rug and carpet cleaning. Pediatrics 1991; 87 (5):663-9.
  • 65. Fatica N.S., Ichida F., Engle M.A., Lesser M.L. Rug shampoo and Kawasaki disease. Pediatrics 1989; 84 (2):231-4.
  • 66. Klein B.S., Rogers M.F., Patrican L.A., еt al. Kawasaki syndrome: a controlled study of an outbreak in Wisconsin. Am J Epidemiol 1986; 124 (2):306-16.
  • 67. Rauch A.M., Kaplan S.L., Nihill M.R., et al. Kawasaki syndrome clusters in Harris County, Texas, and eastern North Carolina. A high endemic rate and a new environmental risk factor. Am J Dis Child 1988 142 (4):441-4.
  • 68. Davis R.L., Waller P.L., Mueller B.A., Dykewicz C.A., Schonberger L.B. Kawasaki syndrome in Washington State. Race-specific incidence rates and residential proximity to water. Arch Pediatr Adolesc Med 1995; 149 (1):66-9.
  • 69. Tang R.B., Hwang B.T., Tsai L.C., Lin F.M., Chang H.N. The significance of mite antigens in Kawasaki disease. Chung Hua Min Kuo Wei Sheng Wu Chi Mien I Hsueh Tsa Chih 1987; 20 (1):29-36.
  • 70. Hicks R.A., Murphy J.V., Jackson M.A. Kawasaki-like syndrome caused by carbamazepine. Pediatr Infect Dis J 1988; 7 (7):525-6.
  • 71. Matsuoka S., Tatara K., Nakagawa R., Mori K., Kuroda Y. Tendency toward atopy in Kawasaki disease. Eur J Pediatr 1997; 156 (1):30-2.
  • 72. Bharati S., Engle M.A., Fatica N.S., et al. The heart and conduction system in acute Kawasaki disease: report of fraternal cases – one lethal, one relapsing. Am Heart J 1990; 120 (2):359-65.
  • 73. Iwata F., Hanawa Y., Takashima H., Shimoura K., Nishibayashi Y. Kawasaki disease in a father and son. Acta Paediatr Jpn 1992; 34 (1):84-6.
  • 74. Fujita Y., Nakamura Y., Sakata K., Hara N., Kobayashi M., Nagai M., Yanagawa H., Kawasaki T. Kawasaki disease in families. Pediatrics 1989; 84 (4):666-9.
  • 75. Kaneko K., Unno A., Takagi M., Maruyama T., Obinata K. Kawasaki disease in dizygotic twins [letter]. Eur J Pediatr 1995; 154 (10):868.
  • 76. Matsubara T., Furukawa S., Ino T., Tsuji A., Park I., Yabuta K. A sibship with recurrent Kawasaki disease and coronary artery lesion. Acta Paediatr 1994; 83 (9):1002-4.
  • 77. Barron K.S., Murphy D.J. Jr Kawasaki syndrome: still a fascinating enigma. Hosp Pract (Off Ed) 1989; 24:51-60.
  • 78. Barron K.S., Silverman E.D., Gonzales J.C., et al. Major histocompatibility complex class II alleles in Kawasaki syndrome-lack of consistent correlation with disease or cardiac involvement. J Rheumatol 1992; 19 (11):1790-3.
  • 79. Kato S., Kimura M., Tsuji K., Kusakawa S., Asai T., Juji T., et al. HLA antigens in Kawasaki disease. Pediatrics 1978; 61 (2):252-5.
  • 80. Krensky A.M., Berenberg W., Shanley K.. Yunis E.J. HLA antigens in mucocutaneous lymph node syndrome in New England. Pediatrics 1981; 7 (5):741-3.
  • 81. Krensky A.M., Grady S., Shanley K.M., Berenberg W., Yunis E.J. Epidemic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome. Hum Immunol 1983; 6 (2):75-7.
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