Candidemia In Hospitalized Patients In Saint-Petersburg

Clinical Microbiology and Antimicrobial Chemotherapy. 2002; 4(1):15-21

​ Klimko N.N., Bogomolova T.C., Kolb Z.K., Saturnov A.V., Perekatova T.N., Belogurova M.B., Lebedev V.F., Shliapnikov S.A., Petrova E.M., Sokirski E.K., Zuzgin I.S., Shneyder T.V., Karyagin I.E., Edelstain V.A., Timokhovskaya G.J., Kolbin A.S., Pestova L.A., Ivanuk F.V.
candidemia acute disseminated candidosis Candida fluconazole amphotericin B
Section
Diseases and Pathogens
Type
Journal article
Publication
Clinical Microbiology and Antimicrobial Chemotherapy. 2002; 4(1):15-21

Abstract

During prospective study carried out in 1998–2000 risk factors, spectrum of pathogens, treatment options and mortality in 45 episodes of candidemia in 45 patients from 16 Saint-Petersburg’s hospitals have been analyzed. Majority (84%) of patients with candidemia were hospitalized in intensive care units (ICU), 13% – in therapeutic wards and 3% – in surgical one. The main reasons for admission in ICU were operations (36%), neoplasms (33%) and traumas (13%). Etiologic agents of candidemia were Candida parapsilosis (32%), C.albicans (28%), C.tropicalis (10%), C.glabrata (8%), С.guilliermondii (2%), C.famata (2%), C.zeylanoides (2%), C.rugosa (2%), С.krusei (2%), C.lusitaniae (2%), Candida sp. (10%). Two and more species of Candida spp. has been isolated from blood in 9% of patients. Localized lesions in different organs have been found in 38% of patients. Antifungal therapy was administered to 60% of patients; intravenous catheters were removed in 68%. Total mortality within 30 days after diagnosis of candidemia was 49%. Mortality in patients who received antifungal therapy was 37%, in patients without specific therapy – 72%. Mortality after removal of intravenous catheter was 35%, without removal – 92%.

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